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Cystic Fibrosis: The Facts is a comprehensive, informative, and well-written book about the disease and its treatments. Ann Harris and Maurice Super address the book to a general audience, making the book extremely accessible to laypeople. Cystic Fibrosis: The Facts is an ideal source for people suffering from cystic fibrosis or for people who have loved ones suffering from the disease. Harris and Super divide the 129-page book into several well-defined chapters. The first chapter addresses the fundamentals of the disease, introducing the audience to the terminology, treatment modalities, and demographics of the disease. The opening pages of the book serve as both summary and introduction. A brief personal account is provided in Chapter 2: Living with Cystic Fibrosis. The author of the account is only 14 years old, adding weight and sentimentality to the story. The following three chapters are dedicated to the technical physiology of cystic fibrosis. While these chapters are filled with medical terminology and examinations of the human anatomy especially affected by the disease, the authors take care not to bog down their text with jargon. Every word is well-defined and only pertinent information is provided. Extraneous facts, data, or statistics do not clutter the pages of Cystic Fibrosis: The Facts, probably because it is published as a trade paperback. Chapter 6 is devoted to the psychology of cystic fibrosis, Chapter 7 to genetics, and Chapter 8 elucidates new treatment modalities. The authors present a summary of organizations concerned with cystic fibrosis in Chapter 9, which is supplemented by an appendix about the International Cystic Fibrosis Association. A thorough glossary is also provided, which is further testimony to the usability of this book.
Cystic fibrosis is a congenital disease that mainly affects the digestive and respiratory systems. Common symptoms include chest infections and steatorrhoea, a condition resulting in particularly malodorous stools. However, symptoms vary from person to person. Because it is a genetic illness and because symptoms often appear in newborns, cystic fibrosis is usually diagnosed soon after birth. While there is no cure for cystic fibrosis, there is a plethora of treatment modalities to ease symptoms and extend life expectancy. The average life expectancy of a person suffering from cystic fibrosis is only 40 years. The disease mainly affects Caucasians: between 1 in 1500 and 1 in 2500 births per year. The authors estimate that four to five births per day in the United States are affected.
Until the early 20th century, cystic fibrosis was not recognized as a distinct malady because its symptoms seemed unrelated. However, the coexistence of gastrointestinal and respiratory problems was recognized as a unique disease by the middle of the 20th century. The term cystic fibrosis refers to cysts, or fluid-filled scar tissue, that interferes with proper pancreatic functioning. The cysts cause excess mucous buildup in the lungs and digestive system, which leads to a multitude of problems People suffering from the disease cannot absorb nutrients from food properly, and are subject to chest infections. Cystic fibrosis also affects the sweat glands. Moreover, most men with cystic fibrosis will be infertile. The same effect is not shared by women, who can successfully give birth. The severity of the disease varies from person to person, as do the symptoms. Cystic fibrosis is caused by abnormal recessive genes on chromosome 7.
Both the upper and lower parts of the respiratory "tree" are affected by cystic fibrosis. The upper part of the respiratory tract includes the sinuses, the nasal passages, and the trachea, or windpipe. Cystic fibrosis may cause a condition called nasal polyps, which are growths in the mucous membranes of the nose that require surgery for removal.
Cystic fibrosis can lead to emphysema, a condition characterized by reduced lung elasticity and caused by excess mucous buildup in the lungs.
Weakening of the walls of the bronchial tubes, or bronchiestasis, is another severe problem associated with cystic fibrosis that can lead to permanent infections and "clubbing" of the extremities. People who suffer from cystic fibrosis commonly contract bacterial infections of the lungs, of which the most common is staphylococcus. Patients can also acquire fungal infections in the respiratory tract. Most of the complications caused by cystic fibrosis that affect the respiratory system are caused by mucous.
The digestive tract is another major victim of cystic fibrosis and is noticeable even before birth, as the fibrous scar tissue replaces normal pancreatic cells. This process is part of the degenerative process of cystic fibrosis. A decrease in the pancreatic juices severely…[continue]
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Cystic Fibrosis (CF) is genetically inherited through a defective gene, which results in the body producing "abnormally thick and sticky fluid, called mucus. This mucus builds up in the breathing passages of the lungs and in the pancreas, the organ that helps to break down and absorb food." (PubMed Health, 2011) Reports state that millions of Americans carry the defective Cystic Fibrosis gene however; most do not have any symptoms since
" (Karem et al., 1073) With an increased focus today on the genetic implications of the condition, enhanced abilities to understand the behaviors of human DNA are opening the door to a more perceptive response to the condition in question. As the text by Davis (1993) indicates, "as mutational analysis and patient data continue to be compiled, patient genotyping should prove useful in both prognosticating and providing a framework for evaluating
116). This point is also made by Goozner (2004) who suggests, "Even when a genetic flaw causes disease, it doesn't automatically mean that it can be treated by replacing the defective or missing protein with its biotechnologically created equivalent. Cystic fibrosis is the classic example" (p. 30). The treatment protocols that are currently in use are therefore designed to address the immediate symptoms of the condition, which in many cases
Cff.org/will each be the source of information and professional peer reviewed articles will be cited from these sources and identified by source as they cited. There is a wealth of available information, data and studies on CF. What it all means to the patients who suffer from this debilitating and life-threatening disease will be understood as this essay proceeds. Chapter One Diagnosis and the Anatomy and Physiology of a Life Threatening Disease: Cystic
However, treatments can be used to reduce, if not nearly completely diminish, symptoms and minimize any other complications. Here are the conditional means: Therapy: People with cystic fibrosis need a way to physically remove thick mucus from their lungs. This is often done by manually clapping with cupped hands on the front and back of the chest -- a procedure that's best performed with the person's head over the edge of
This in turn leads to cytoplasmic water retention and the buildup of viscous mucus in the lungs and other areas of the body. This is particularly problematic for the lungs because the thick mucus impairs clearance of invasive particles and infectious agents to maintain a sterile environment. Microbial contamination of airway surfaces triggers an inflammatory response, including a massive invasion by neutrophils (Rodrigues et al., 2008). As the neutrophils react
cystic fibrosis. There are eleven references used for this paper. There are a number of fatal diseases which a person can be born with in the world today. One of the most debilitating is Cystic Fibrosis. It is important to examine its history, symptoms, diagnostic procedures, treatments and prognosis in order to gain a better understanding of this disease. Cystic fibrosis is a "recessive disorder common among Caucasians. Although the disease