Bone Marrow Advocacy Bethematch.org is the website for the National Bone Marrow Donor Program. Through the website and the Be the Match organization, people can register to become potential bone marrow donors. Be the Match is the central bone marrow donation registry for the United States. It is a non-profit organization, and it works with doctors, patients, and donors to help match recipients. It does not provide compensation to donors and does not require payment from patients in order to provide matches. Becoming a potential donor registered with Be the Match is an easy process, which requires little initial commitment from potential donors, though any person signing up as a potential donor should be prepared for a high level of commitment is chosen as a match for a patient.

Bone marrow transplants can be used to treat a variety of different medical functions, and the concept of marrow donation has been around for well over 100 years. For example, in the late 1800s, patients received bone marrow orally in order to treat blood disorder (Armitage, 1994). This oral use of blood marrow was not successful, but did reveal a growing awareness that marrow could be used to help treat blood disorders and marrow disorders. This scientific knowledge grew so that, as early as the 1930s, doctors were beginning to experiment with the injection of bone marrow from donors into recipients. The field has expanded greatly in the last few decades, with bone marrow transplants offering significant medical options to people with a variety of diseases.

When discussing donating bone marrow, it is important to realize that there are two broad different types of bone marrow transplants: autologous and allogenic. Autologous transplants are when a donor gives marrow to donate to himself or herself. This type of donation does not require a donor other than the patients. These types of transplants are successful in the treatment of lymphoma (Armitage, 1994). However, there are several other sources of stem cells that can be given in allogenic transplants: synegenic refers to an identical twin donor; human leucocyte antigen (HLA) matched siblings or family members; HLA matched unrelated donor; HLA antigen mismatched donor; haploidentical donor (HLA haplotype matched); and umbilical cord blood donor (Clark & Craddock, 2007). Allogenic transplants occur when a person other than the donor donates bone marrow to another person. While siblings provide the best opportunity for a bone marrow match, the reality is that most people in need of allogenic marrow donations do not have a sibling who will match them. Therefore, bone marrow registries are an important way to match recipients and donors.

Bone marrow donations can be used to treat a variety of diseases and, in some circumstances may offer the only cure for patients with certain diseases. Several types of leukemias and lymphomas are treatable by bone marrow transplant, which can even cure them (National Marrow Donor Program, 2013, Diseases). It can also be used to treat a variety of bone marrow and blood related diseases, including: severe aplastic anemia, Fanconi anemia, paroxysmal nocturnal hemoglobinuria, pure red cell aplasia, and amegakaryocytosis / congenital thrombocytopenia (National Marrow Donor Program, 2013, Diseases). Bone marrow transplants may be used to combat inherited immune system disorders such as: all types of severe combined immunodeficiency (SCID) and Wiskott-Aldrich syndrome (National Marrow Donor Program, 2013, Diseases). Bone marrow transplants may treat diseases that impact red blood cell function (hemoglobinopathies), such as: beta thalassemia major, sickle cell disease, Krabbe disease (GLD), Hurler syndrome, adrenoleukodystrophy (ALD), metachromatic leukodystrophy (MLD), myelodysplastic syndromes, and myeloproliferative disorders (National Marrow Donor Program, 2013, Diseases). Bone marrow transplants have also been used to treat: multiple myeloma; plasma cell disorder; familial erthrophagocytic lymphohistiocytosis and other histocytic disorders; and other cancers and malignancies (National Marrow Donor Program, 2013, Diseases).

While it is possible to match those who need bone marrow donations with unrelated donors, the matching process can be arduous. In many instances, patients and family members are left in a difficult scenario, aware that a bone marrow transplant is needed and without a potential donor for the recipient. This can result in people seeking to educate others about bone marrow donation and asking people to sign up and be tested for the registry (Attwood, 2004). In some instances, these please for donors are successful. However, in other instances they are not, and people miss a possible cure for a terminal disease because of a lack of matched donors. Be the Match and the...

The goal of the National Marrow Donor Program is to maintain a registry of people willing to donate their bone marrow, which can then be matched with patients in need of bone marrow donations.
Becoming a bone marrow donor is a way for a person to save the life of another person. The process itself is relatively simple. A bone marrow transplant involves taking the healthy blood-forming cells, either directly from a donor's marrow or from their blood stream, and placing them in the bloodstream of a patient. Once transplanted, these cells then form healthy blood components: red blood cells, white blood cells and platelets. "Patients receive high doses of chemotherapy to prepare their body for the transplant. Then on transplant day, the patient receives the donated cells in a process that is like getting blood or medicine through an intravenous (IV) catheter, or tube" (National Marrow Donor Program, 2013, How bone).

Becoming a bone marrow donor is also a relatively simple process. Through a simple cheek swab, a potential donor can have his or her bone marrow information stored in a national registry. When a potential recipient match enters into the registry, the preliminary match receives further testing for compatibility and a bone marrow transplant is arranged. Of the volunteers in the national donor registry, approximately 1 in 540 is eventually chosen to become donors (National Marrow Donor Program, 2013, FAQs). If a potential donor is chosen, the donor needs to make a 30-40-hour commitment over an approximately four to six-week period of time in order to go to appointments and make arrangements to provide the donation to the patient (National Marrow Donor Program, 2013, FAQs).

The donation process itself depends on what type of bone marrow procedure is conducted on the patient. First, marrow donors can actually donate through peripheral blood cell donation or through bone marrow donation; peripheral blood cell donation is the less painful and less time consuming of the two procedures . "Peripheral blood cell (PBSC) donation involves removing a donor's blood through a needle in one arm. The blood is passed through a machine that separates out the cells used in transplants. The remaining blood is returned through the other arm" (National Marrow Donor Program, 2013, FAQs). For PBSC donation, the donor receives granulocyte-colony stimulating factor (G-CSF) in order to raise the peripheral blood white cell count (Clark & Craddock, 2007). High dose GSF not only raises the peripheral white blood cell count, but also causes CD34+ stem cells to migrate from the marrow into the blood (Clark & Craddock, 2007). After four or five days, the donor then undergoes a leukapheresis procedure to collect white cell cells and CD34+ stem cells from the blood (Clark & Craddock, 2007). This procedure is much easier on the donor and the recipient than traditional bone marrow donation. "Compared with bone marrow as a graft, peripheral blood stem cells (PBSCs) provide faster blood count recovery and better immune reconstitution post-transplant. PBSC collection is a day-case procedure, which avoids anaesthesia and there is no evidence of long-term effects from G-SCF administration to healthy volunteer donors" (Clark & Craddock, 2007). The donors may experience some side effects, including: myalgia, bone pain, and headache (Clark & Craddock, 2007). In addition, if PBSC does not yield sufficient marrow cells, the donors may need to have their marrow harvested through traditional techniques (Clark & Craddock, 2007).

Donating actual bone marrow is a more complicated process and involves a higher commitment. Traditional bone marrow donation is a surgical procedure, and, as such, has some risks for the donor. During a traditional bone marrow transplant, the liquid marrow is taken from the donor's bones; specifically from the back of a donor's pelvic bones. This is done with a needle. The process itself is painful, because the donor is anesthetized during the extraction. However, "most donors feel some pain in their lower back for a few days afterwards" (National Marrow Donor Program, 2013, FAQs).

Regardless of how marrow is obtained, there is an inherent risk of rejection with any bone marrow donation. Prior to a marrow donation, high dose chemotherapy is employed to dramatically weaken the recipient's immune system, so that the bone marrow donation has less chance of being rejected. However, rejection is always a possibility. This rejection is lumped under the name Graft vs. Host Disease (GVHD) and encompasses a range of immune responses that can compromise the ability of the…