Comprehensive Health History

¶ … Health History Health Condition: On Set: Patient, Diana Cates, age 47, has been suffering from Thyroidectomy. The patient cannot tolerate synthoid as it aggrevates and the central tremors even at lowest dose. Currently he has enlarged right thyroid. How long: thyroid, Pt., thyroidectomy since 1993 Causes and Effects of Health Condition: Provocative/pallative: Precipitating factors: Quality of Health Condition: It's located in the thyroid and it does not spread. Long-Term Care: The thyroid problem affects her walking due to her weight and the pain.

On a scale from 1 to 10, the condition is a 7 since it does seem to be worst when the patient walk which mostly during the day. Early Stages of Health: Timing: The patient's trouble began 1993 and it does not seem to be better or worse. As time goes by, the thyroid condition may be better with proper care. Treatment: Understanding: The patient has the condition of thyroidectomy and it can Can get better over time.

The effects of a thyroidectomy and thyroxine (T4) replacement on the spontaneous and human chorionic gonadotropin (hCG)-stimulated secretion of testosterone and the production of adenosine 3',5'-cyclic monophosphate (cAMP) in rat testes were studied. Thyroidectomy decreased the basal levels of plasma luteinizing hormone (LH) and testosterone, which delayed the maximal response of testosterone to gonadotropin-releasing hormone (GnRH) and hCG in male rats. T4 replacement in thyroparathyroidectomized (Tx) rats restored the concentrations of plasma LH and testosterone to euthyroid levels.

Thyroidectomy decreased the basal release of hypothalamic GnRH, pituitary LH, and testicular testosterone as well as the LH response to GnRH and testosterone response to hCG in vitro. T4 replacement in Tx rats restored the in vitro release of GnRH, GnRH-stimulated LH release as well as hCG-stimulated testosterone release. Administration of T4 in vitro restored the release of testosterone by rat testicular interstitial cells (TICs). The increase of testosterone release in response to forskolin and androstenedione was less in TICs from Tx rats than in that from sham Tx rats.

Administration of nifedipine in vitro resulted in a decrease of testosterone release by TICs from sham Tx but not from Tx rats. The basal level of cAMP in TICs was decreased by thyroidectomy. The increased accumulation of cAMP in TICs following administration of forskolin was eliminated in Tx rats. T4 replacement.