Vitamin D supplementation and glycemic control in type 2 diabetes: systematic review of clinical trials
This order is a table review of four studies discussing the link between vitamin D and type two diabetes insulin absorbtion. The studes were generated by the customer and reviewed and summarized in the table. All studies were from the last five years and followed standard study requirements. This paper does not have any additional resources and is not in any specific format.
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Diabetes and Vitamin D Studies
Evaluation Table
Clearly Focused Issue
Appropriate Method to Answer the Research Question
Acceptable Recruitment Methods
Acceptable Method of Selection of Controls
Minimization of Bias
Were the Confounders Accounted for in the Study Design
Are the Results Believable
Are They Applicable to Other Populations (Generalizable)
Do the Results Fit with Available Evidence
Witham et al., 2010
This is a follow-up study. The issue is whether patients with a vitamin D level of higher than 250 HD will gain a benefit from vitamin D supplementation.
A positive result is defined by reaching a level of 75 nmol or above. This is considered the level for optimum health.
Patients for the study were selected from general practice and diabetes specialty offices based on a positive type 2 diabetes mellitus diagnosis in accordance with the requirement set forth by the World Health Organization.
The group was divided into three sub-groups. The control had a placebo. The other two groups were given 100,000 IU and 200,000 IU of vitamin D2.
The people for each group were randomly selected by a computer and assigned a numeric code. The actual grouping was unknown to the researchers until after the study was complete and the data entered.
The primary confounder accounted for in this study was whether vitamin D always gives a positive reaction. This was accounted for by using two differing doses. If the research theory is correct, then the larger dose will provide an improved outcome.
The results were that neither dosage significantly improved the patient's diabetes symptoms.
These findings are applicable to all populations of those with type 2 diabetes.
This result does fit within the available evidence, as all studies have found some, but no substantial improvement.
Von Hurst et al., 2010
This study seeks to investigate the effect of improved vitamin D status on markers of metabolic syndrome, primarily IR, in South Asian women who were insulin and vitamin D deficient.
Study is the standard randomized, placebo controlled, double-blind.
Standard recruitment.
Standard placebo controlled study.
The study is double-blind to eliminate bias.
Confounders were accounted for as with all other studies.
These results are believable, as the only difference was the increased dosage to a much higher level than any other study.
No, this study seems to be specific to Asian women with low vit D. levels and low insulin levels.
These results differ from the other evidence, as the results showed a recordable improvement above the margin of error.
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