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Fighting cancer is among medical science's greatest challenges and it is to this field of specialty I have been drawn. For the past several years I have devoted my time and energies to laboratory research projects involving the synthesis of histone deacetylase (HDAC) inhibitors. HDAC inhibitors have emerged as one of the most promising chemical agents in counteracting cancer. Our goal for the past year has been to synthesize a new HDAC inhibitor. Our research was based on prior research and we are endeavoring to add to the growing body of scientific literature in this area. My work involves the synthesis, purification, characterization, and submission of the chemical compounds for biological screening or in vivo tests. Our research team successfully synthesized several new compounds of hydroxymic acid. We also developed a benzamide compound that is now known as MS-275, which was patented by Merck. Synthesizing MS-275 was one of the highlights of my career so far. Quite by accident I discovered that I can skip turning the carboxyl acid group into acid chloride for a far higher isolated yield of MS-275. The results of my study were promising, as they increased yield to 65% from 53%. I look forward to further breakthroughs in compound synthesis.
Prior to my full-time medical research work I was involved in Pfizer's file enrichment program, developing process chemistry methods. Our research team conducted platform chemistry reactions including high-throughput library synthesis and parallel synthesis of small drug-like compounds. In a similar vein, as assistant to the senior scientist of the project, I selected regeant monomers and evaluated optimized conditions for chemistry library protocols.
Another highlight of my career so far is my contribution to the synthesis of Cytosine and its analogs. Cytosine shows promise as a treatment for Alzheimer's disease, Parkinson's disease, pain, addiction to smoking, ulcerative colitis, obesity and anxiety disorder. However, no synthetic Cytosine is available in clinical settings yet, so further research is required in this area. Our goal was to prove the possibility of parallel synthesis of different cytosine analogs using Arqule technology and methodology. Our team successfully developed a template for synthesis, a protocol involving eight different reaction steps.
As you can glean from this brief explanation of the work I have done so far, my talents in the laboratory are proven and I look forward to contributing further to the scientific community through published works.
SCIENCE FICTION & FEMINISM Sci-Fi & Feminism Origins & Evolution of Science Fiction As with most things including literature, science fiction has progressed and changed a lot over the years. Many works of science fiction were simply rough copies and following the altready-established patterns of prior authors. However, there has always been authors and creators that push the envelope and forge new questions and storylines that have not been realized or conceptualized before.
This is related to bronchitis, asthma and long-term conditions such as lung cancer and bladder cancer (Robinson, 2009). It is estimated that the chances of getting bladder cancer is high for ex-smokers and passive smokers even after thirty years later. This brings us to the question of management of bladder cancer for current and ex-smokers as well as passive smokers. The management of bladder cancer is a three-pronged approach that involves
Nephrologists are expected to play a role in this determination, but all too often the nephrologist, like other physicians, must be prompted to deal with end-of-life issues. If no one is available to do the prompting, the patient's death may be needlessly prolonged. The amount to which the nephrologist takes on end-of-life care will be reflected in their approach to the patient. At one end of the spectrum, discomfort
"You could say that anything that makes you feel better," Bock says, "whether chocolate or sex or invigorating exercise or a relaxing evening (depending on one's condition or circumstances), is good for you and could be viewed as medicine. Indeed, most Americans use the term 'good medicine' metaphorically and sometimes almost literally to describe some function or activity that promotes a sense of well-being" (131). Certainly, crack addicts would maintain
Lesbian Health Care Lesbian Health Issues in a Heterosexual Society The additional burdens placed on the lives of minorities as a result of social exclusion can lead to health disparities. Social exclusion theory has been used in previous research to investigate the health disparities that exist between socioeconomic classes and individuals of different ethnic backgrounds living in the United States, but it has not yet been applied to another important minority group:
Health Consequences of Air Pollution for Military and Emergency Workers Database Validity and Originality This paper proposes a study of some of the most significant long-term and short-term effects of air-pollution on two different sets of workers. The first of these is those were affected by localized and intense air pollution that was produced as a direct result of the Gulf War, pollution that was caused for the most part by the