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Gene therapy is another method that can help replace defective genes in carriers to protect future generations but this is a highly expensive procedure that not everyone can afford. Hemophilia has a long history and it has been found in members of the royal family of England.
There are some important facts that we should know about hemophilia since they help in dispelling popular myths. Not all forms of hemophilia are caused by deficiency in Factor VIII. While 80% of hemophilic cases are like that, the rest are affected by hemophilia B. that is actually a deficiency in Factor IX.
It is also believed that patients with hemophilia have medical family history of the disease. But that is not entirely true. In almost 1/3 cases of hemophilia, there was no family history found. It is claimed that in these patients, the onset of disease is spontaneous. Some abrupt gene mutation can cause the disease in patients with no family history.
Some claim that this disease only affects males and females can never be hemophilic. This is not true because while the disease in commonly found in males,...
That happens usually when both parents have hemophilic genes which means mother is carrier and father is infected. In that case, the girl is almost 50% at risk of developing hemophilia. In some cases, women can found with hemophilia like condition as low levels of clotting factors cause abnormal bleeding for prolonged period.
Some feel that patients of this disease can bleed to death from a simple cut or wound. This is also partially true. This is because while blood clotting takes a longer in hemophiliacs, the rate at which blood flows out doesn't differ. In most cases, this bleeding can be stopped by ordinary methods such as applying pressure and using ice. These patients are at a greater risk of dying from internal bleeding and wounds that are invisible. Even if death is no an immediate threat, prolonged bleeding can cause pain and swelling in joints which can cause disability.
REFERENCE
Hemophilia" the Columbia Encyclopedia, Sixth Edition; 4/22/2004
New treatment for hemophilia. (Updates) FDA Consumer; 11/1/2003
REFERENCE
Hemophilia" the Columbia Encyclopedia, Sixth Edition; 4/22/2004
New treatment for hemophilia. (Updates) FDA Consumer; 11/1/2003
The viruses that cause AIDS (HIV) and hepatitis can be carried in clotting factors however there have been no documented cases of such transmission in about ten years. Prevention of viruses can be prevented by: careful screening of donors; testing of donated blood products; treating donated blood products with a detergent and heat to destroy viruses (Hemophilia 2006). Both preventive and as-needed therapy can be administered at home, thus
Occurrence of inherited hemophilia is slightly more likely in Caucasians (1.3%) as opposed to African-Americans (1.1%) and Hispanic (1.2%). Asian populations appear to inherit the gene far less likely, about 1/4 of that of Caucasians. However, modern demographics result in marriage between ethnic types far greater than previous, and statistics show a blending to about 1% of most populations (Soucie, et.al., 1998.) Abnormality -- as a genetic occurrence, hemophilia infects
DNA Finger Printing Techniques to retrieve DNA and the development of DNA probes have come up and made it possible the matching of DNA molecules to other DNA molecules to serve purposes like identification. This process has been incorporated into what is known as DNA fingerprinting.DNA fingerprinting is therefore a test for identification and evaluation of genetic information i.e. ones DNA. This technique is referred to as a fingerprint because two
The most common treatment for hemophilia is replacement therapy, where concentrates of the clotting factors (factor VIII for hemophilia A or factor IX for hemophilia B) are administered to the patient. Clotting factors can be obtained from treated human blood sources or recombinant sources. (NHLBI, n.d.) Recombinant factors "are made by inserting the DNA encoding the human protein into mammalian cells grown in culture. They are purified and processed and
With recessive genes (in which both mother and father have to contribute a 'positive' set of the same genes) are designed to work in precisely the same way that hemophilia does: One out of four offspring (on average) will have the condition, two will be carriers, and one will be neither sick nor a carrier. Klinefelter's syndrome, on the other hand, arises from a mechanical mistake that occurs on the
Phenotype How variations arise within a phenotype? Phenotype is the specific characteristics that are displayed by the organism. Phenotypic variation is a prerequisite for evolution due to natural selection, thus without the former, there is no latter. Qualitative traits are traits that show a difference between phenotypes like skin color, sex, and eye color. However, such descriptions are controlled by a small number of genes so environmental influence on these traits is