Database Search for Biochemistry Breakthroughs

Database Search for Biochemistry Breakthroughs With Celiac Disease

When using database tools to determine up-to-date information on a health topic, it is essential to know how to search. In general, there are three types of articles to consider, primary articles are those that present new research and are found in medical journals (McMillan, 2010). Secondary sources are those that summarize and compare existing data. Opinion sources are those that evaluate the current data and interpret it. All three of these sources are vital to ensure an ideal research background in a topic (Fraenkel, 1993). For this paper, the topic of biochemistry breakthroughs with celiac disease will be explored.

The initial search was run in CINAHL. The search is open text and open date using the words Celiac Disease Biochemistry. This initial search retrieved 10,100 results. The first article listed is titled Identification of tissue transglutaminase as the autoantigen of celiac disease and is dated 1995. In order to trim down the results and ensure that the articles are truly the latest information on the topic, the date range is now changed to since 2013. This reduces the amount of articles to 238. The first listed article is titled Gluten-sensitive enteropathy coincides with decreased capability of intestinal T cells to secrete IL-17 and IL-22 in a macaque model for celiac disease. This article is published in the journal of Clinical Immunology and appears to be primary source article. The second article listed for the topic is Differentiation between Celiac Disease, Nonceliac Gluten Sensitivity, and Their Overlapping with Crohn's Disease: A Case Study. This study is a secondary source as it simply analysis existing cases without presenting any new information. The third resource listed is titled Celiac Disease: The New Proposed ESPGHAN Diagnostic Criteria Do Work Well In a Selected Population. This article is an opinion or news source detailing recent breakthroughs and listing further articles that discuss those breakthroughs. This article would obviously be useful to shepherdize and further search the listed articles for more information.

The next database used for the search is Medline. I began with the same search terms, celiac disease biochemistry, however it did not return any articles. Next, the search was expanded my search by simply searching celiac disease. This returned 544 articles. The first article is titled Celiac Disease and is from the National Library of Medicine. This article is clearly not useful. Next the search was expanded to celiac disease chemistry. This search returned 23 results. From scanning these titles, the information is very useful, detailing the latest genetic research and vitamin interaction research. The first listed is Vitamin D Test. This article comes from a website and is informative in nature, but makes no reference to any specific studies. This article cannot therefor, be credibly used for research. The next article is from the same website and is titled Vitamin B12 and Folate, it is clear that Medline is not a reliable source for information on this topic when considering academic research; however, it may be useful for informational research for patients as the articles are written in simple English and informational in nature.