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Phenoxodiol, a Medication for Cancer
Clinical studies have predominantly focused on a couple of standard benzopyrans, namely flavopiridol and phenoxodiol (by Novogen, via MEI Pharma, the company's subsidiary at the time). Although a benzopyran, the former's method of action apparently differs from phenoxodiol's action neither of the two aforementioned benzopyrans has gained FDA (Food and Drug Administration) or EMA (European Medicines Agency) approval. The height of research on phenoxodiol was one 'Phase III' research on resistant cancer cells in the ovaries. Although slow recruitment led the trial at this phase to formally close down, results clearly displayed that oral consumption of phenoxodiol would most probably not have benefited patients, if the trial phase had been completed. Phenoxodiol results (in combination with others) led to the following hypothesis by Novogen: the problem with phenoxodiol pertained to bioavailability (in other words, the ingested drug wasn't reaching the site of cancer in adequate quantities); thus, there was a lack of adequate activity at the site of the cancer (Marc Sinatra, 2015).
The project which resulted in Cantrixil's development was, apparently, initially focused on seeking phenoxodiol's successor to treat ovarian cancer. While the end product of the experiment is nevertheless associated with ovarian cancer, it is being aimed at pleural and peritoneal cancers. Further, organizations...
The researchers of a recent study explored phenoxodiol's impacts on cancer cells in the human gallbladder, in an attempt to ascertain if phenoxodiol was capable of enhancing gemcitabine antitumor activity in case of gallbladder cancer. A combination of gemcitabine-phenoxodiol proved to be a more potent treatment, when it came to cell proliferation inhibition, as compared to both chemotherapeutic agents alone. Moreover, antitumor impacts of a gemcitabine-phenoxodiol combination on cancer cells in the gallbladder was studied via a mouse xenograft model for gallbladder cancer; results indicated that phenoxodiol led to enhanced in-vivo gemcitabine antitumor activity. Taken together, the research work indicated that gemcitabine-phenoxodiol combination treatment can provide optimal therapeutic advantages for gallbladder-cancer patients (Yu Li, Xiaoqiang Huang, Zhiqiang Huang, & Jian Feng, 2014). Phenoxodiol represents a new-gen anti-cancer medication coming under the 'signal transduction inhibitor' category of drugs, which induce programmed cancer-cell death (apoptosis), and have no or minimal impact on the normal cells in the patient's body (Marshall Edwards Inc.,…
References
Marc Sinatra. (2015). Novogen Limited. Lodge Partners Research.
Marshall Edwards Inc.2003Investigational New Drug Status Cleared By FDA for Phenoxodiol in Oral Formpr Newswire
Paul Howard. (2015, November 1). Why The FDA Rejected A Drug That Helps Cure Lung Cancer -- And What We Can Do To Fix It. Forbes.
U.S. Department of Health and Human Services1998Guidance for Industryrockvillefood and Drug Administration
A mutation of the gene causing colorectal cancer or epithelial ovarian cancer are major risk factors for ovarian cancer, and genetic testing within the laboratory can identify most of these. However, the women who possess these inherited genes are at less risk than those women who do not have any family history of ovarian cancer, and while the former group can be treated with advanced planning and genetic counseling,
These include bloating, abdominal or pelvic pain, frequent and/or urgent urination, and difficulty eating because one feels very full very quickly (MedicineNet, 2009). However, these were only agreed upon in 2007 and not all doctors feel that these are the best markers of ovarian cancer (MedicineNet, 2009). A lot of women experience at least the first two of these symptoms quite often during their menstrual cycle, and the others
This type of prevention involves the complete removal of both breasts and all breast tissue. By having this operation individuals are able to completely eliminate the risk of having breast cancer. In most cases this procedure is only done on women who have many members of their family (mothers, grandmothers, aunts) that have been diagnosed or died from breast cancer. In such instances there is usually a genetic reason
4 months in the placebo group. (P=0.01) [Kyogo et.al] an earlier study by Nestle et.al (1998) had showed promising results. In that study, a small group of renal cancer patients were vaccinated with RNA-transfected dendritic cells. T cell response was noted in most of the treated patients and a follow up study conducted after 19 months showed that 7 out of 10 patients still survived. [Jian et.al, 2008] Other vaccines
Family history of cancer and pre-Disposition of a person to cancer Family Cancer Syndromes DNA, genes, and chromosomes Family cancer syndromes - when should I worry? Family History and Prevalence of Certain Types of Cancer Risk Assessment in Identifying a Family History of Cancer Family Cancer Syndromes Cancer has become a common disease in the world today and the prevalence of the disease is such that in many families one would find at least one person who
In the tissue culture, they usually proliferate indefinitely. The normal constraints which limit the growth of the cells absent in the cancerous state and are also characterized by the division ability for number of generations which is unlimited. Cell cycle and cancer With millions of chemical reactions taking place concurrently and in specific areas, the human body can be thought of as a small laboratory. It is the only "machine" with