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pylori alone but for ruling out the existence of other stomach maladies. It is quite expensive and requires a highly skilled physician.
Stool Antigen Test; this is when the stool is analyzed for detection of any foreign antigens or proteins that are associated with H. pylori infection. The stool is known to be very sensitive and can also be use to assess the infection status after the treatment has commenced. The disadvantage of this method is that it absolutely depends upon the participation and compliance of the patient, it is inconvenient to handle and the results are not immediate. pylori organism thrives best in an acidic environment. For a better response to the antibiotic therapy, histamineH2-receptor antagonists (H2RA) or a PPI has been shown to improve the success of the antibiotic therapy.
Urea breath test; it is used to detect the presence of H. pylori bacteria in the stomach. It can also be used to detect whether the treatment has worked, the problem with this test is that it is not always available (WebMD LLC, 2011).
Treatment of H. pylori
There are a series of pharmacological therapy that have been used in treating the H. pylori bacterium in the human body. The following are the most common pharmacological therapy as indicated in American Academy of Family Physicians (2002);
Antibiotics; here antibiotics like Amoxicillin which is a synthetic penicillin is proven to be one of the most effective antibiotic for H. pylori. This rug has the ability to rapidly accumulate into antral mucosa through the systematic circulation. The effectiveness of this drug highly depends on the pH level, with the increase in pH level there is a reduction in the minimal inhibitory concentration (MIC).
Bismuth Compounds; these are compounds that don't have substantial acid-neutralizing capacity though are known to inhibit pepsin as well as increase the secretion of mucus which consequently forma a barrier that acts as a barrier to the diffusion of acid in the ulcer crater. The compound also cause detachment of H. pylori from the gastric epithelium and upset bacterial cell walls, ending up in lysis of the bacterium.
References
American Academy of Family Physicians (2002). Management of Helicobacter pylori Infection.
Retrieved May 12, 2011 from http://www.aafp.org/afp/2002/0401/p1327.html
Dennis Lee, (2011). Helicobacter Pylori. Retrieved May 12, 2011 from http://www.medicinenet.com/helicobacter_pylori/article.htm
Gastroenterological Society of Australia, (2006). Helicobacter Pylori. Retrieved May 12, 2011
from http://www.gesa.org.au/leaflets/helicobacterpylori.cfm
The BreathID System, (2011). Testing Methods. Retrieved May 12, 2011 from http://www.helicobacterpyloritest.com/h-pylori-breath-testing-methods.html
WebMD LLC, (2011). Helicobacter pylori Tests. Retrieved May 12, 2011 from http://www.webmd.com/digestive-disorders/helicobacter-pylori-tests
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