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Rheumatoid Arthritis
What is happening to the synovium in Arletha's knees and probably her hands as well?
In all likelihood, the synovium is inflamed and is not doing its job. The synovium is meant to secret liquid that keeps the joint lubricated. If it's not present or is not doing its job at high efficiency any more, then the joints in the hands and knees will start to become damaged and broken down, thus leading to pain.
What diagnostic tests may help provide clues to the presence of rheumatoid arthritis?
There is no "single" test or symptom that leads to the diagnosis and verification of rheumatoid arthritis. However, there are about seven symptoms or tests that can lead, in whole or in part, to a rheumatoid arthritis diagnosis. These include morning stiffness in and around joints for at least one hour, swelling or fluid around three or more joints at the same time, at least one swollen area in the wrist, hand or finger, the presence of nodules...
What systemic manifestations might Arletha experience due to rheumatoid arthritis?
She might experience stiffness in the morning for an hour or so (or more) in the hands or knee area. She may have nodules in the affected areas. Moderate to extreme pain may result from the manifestation of cartilage becoming degraded or even destroyed due to the lack of proper synovium in the joint.
4. What treatment plan is expected as Arletha leaves the clinic today?
It will probably include a combination of drugs, steroids and physical therapy. The drugs are necessary to keep the pain down, the steroids help proper growth of synovium and other needed helping factors for the same and the therapy is needed to ensure that the desired level of physical activity is maintainable.
5. What…
As well as several reports relating diseases and mood, mental status has also been reported to affect immuno-regulatory systems. Chronic depression or chronic stress conditions lead to immuno-suppressive status and imbalance in corticotrophin-releasing hormone, which induces cancer and hyperthyroidism. It has been reported that depressive states induce suppression of mitogenic reaction in lymphocytes, decreases the number and activity of natural killer cells and decreases the production of interferon." Sadamoto,
Rheumatoid arthritis is a widespread autoimmune disease that is linked to progressive disability, socioeconomic costs, systemic complications, and even early death. In addition to having an unknown cause, the disease also has a guarded prognosis. In the past few years, there have been several attempts to understand the pathogenesis of the disease, which have resulted in the creation of new therapeutics with enhanced outcomes (McInnes & Schett, 2011, p.2205). As
Though this work focuses specifically on the risk factors of atherosclerosis for RA patients and how to better identify them prior to clinical presentation of atherosclerosis the work is also insightful in that it builds a case for the connection between RA clinical presentations and atherosclerosis, in general. To move forward from this progressive idea is the fact that research has indicated that there is an even greater connection
Rheumatoid Arthritis: Risks/Benefits of Latest Treatments Rheumatoid arthritis (RA) is a form of arthritis characterized by swelling and tenderness which recent studies have revealed that approximately 1% of grownups suffer from. A common symptom of this disease is symmetric polyarticular inflammation of the synovium, typically of the small joints of the hands (MCP and PIP), wrists and feet. This swelling causes discomfort and difficulty of movement and could result into gradual
Introduction Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and progressive destruction of the joints. Understanding its pathophysiology is crucial for developing effective treatment strategies. Immune Dysregulation: RA is mediated by an aberrant immune response involving the activation of T cells and B cells. Dysregulated T cells secrete pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-?) and interleukin-17 (IL-17), which stimulate synovial fibroblasts and promote inflammation. B cells produce autoantibodies,
Therapies/Treatments That Can Be Done to Help the Immune System of a Patient 18-55 Diagnosed With Rheumatoid Arthritis THERAPIES/TREATMENTS TO HELP THE IMMUNE SYSTEM OF An 18-55 PATIENT DIAGNOSED WITH RHEUMATOID ARTHRITIS Therapies/treatments that can be done to help the immune system of a patient 18-55 diagnosed with Rheumatoid Arthritis (RA) Annotated Bibliography Cem Gabay, A, et al. (2013). Tocilizumab Monotherapy vs. Adalimumab Monotherapy for the Treatment Of Rheumatoid Arthritis (ADACTA): A Randomized, Double-Blind,