Human Growth Hormone in Biotechnology
Human growth hormone (GH), also known as somatotrophin, is a protein consisting of 191 amino acids with a molecular weight of ~22,000. Growth hormone is secreted by the pituitary gland, which stimulates growth and cell reproduction. The structure is made up of four helices, which are necessary for functional interaction with the GH receptor. Despite remarkable structural similarities between GH from different species, only human and primate GH may be active in humans.

History of Human Growth Hormone

Growth hormone was first purified from pig and cow pancreas for treatment of type 1 diabetes since the 1920's. However, these types of GH did not function as well in humans, due to greater variation of molecular structure compared to human GH. In 1958, Maurice Raben purified enough GH from human pituitary glands to successfully treat a GH-deficient boy (Raben). In 1960, the National Pituitary Agency was formed as a…...

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Works Cited

Frasier, S.D. "The Not-So-Good Old Days: Working with Pituitary Growth Hormone in North America, 1956 to 1985." J. Pediatr 131.1 Pt 2 (1997): S1-4.

Jorgensen, J.O., et al. "Growth Hormone and Glucose Homeostasis." Horm Res 62 Suppl 3 (2004): 51-5.

Lanfranco, F., et al. "Ageing, Growth Hormone and Physical Performance." J. Endocrinol Invest 26.9 (2003): 861-72.

Orme, S.M., et al. "Mortality and Cancer Incidence in Acromegaly: A Retrospective Cohort Study. United Kingdom Acromegaly Study Group." J. Clin Endocrinol Metab 83.8 (1998): 2730-4.

On the other hand, there are also many in the medical arena who are of the opinion that this view is too radical and essentially unhelpful. Many doctors consider that a strict ethical view of growth hormone treatment would be unreasonable and unfair to the individuals who must bear the burdens of discrimination... It is not easy to dismiss the profound and understandable distress some children experience because they are short. Such children undeniably are disadvantaged by their condition" (Considerations elated to the Use of ecombinant Human Growth Hormone in Children, 1997)
This important ethical debate is also discussed in various other studies. For example, in a study entitled Moral assessment of growth hormone therapy for children with idiopathic short stature (1997) by Verweij and Kortmann, the authors state that one of the greatest ethical dilemmas facing medicine is the prescription of growth hormone treatment for those children who do…...

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References

http://www.questiaschool.com/PM.qst?a=o&d=35226805

Ashmore, R.B. & Starr, W.C. (Eds.). (1994). Teaching Ethics: An Interdisciplinary Approach. Milwaukee: Marquette University Press.

Considerations Related to the Use of Recombinant Human Growth Hormone in Children. PEDIATRICS Vol. 99 No. 1 January 1997, pp. 122-129. Retrieved April 7, 2008, at http://aappolicy.aappublications.org/cgi/content/full/pediatrics;99/1/122

Hintz, Raymond L. (2004) Growth hormone: uses and abuses.

, 1998). Cognitive functioning, particularly memory performance has been found to be impaired in patients with childhood onset of growth hormone deficiency and HGH replacement therapies have been found to offset this memory impairment (Arwert et al., 2005). Studies have identified a link between improved attention and increases in memory performance in children with growth hormone deficiency (Arwert et al., 2005; Arwert et al., 2006). This is due to the connection between memory capacity and attentional resources.
Growth hormone deficiency that begins in childhood is most often treated with growth hormone supplementation in order to increase body size during adolescence (Nieves-Martinez et al., 2009). Yet recent studies have demonstrated that this treatment directly correlates to improved memory in adulthood. In fact studies have suggested that treatment with growth hormone in child onset deficiencies can in fact prevent learning and memory deficits later in life (Nieves-Martinez, 2009). Childhood onset of growth hormone…...

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References

Arwert, L.I., Veltman, D.J., Deijen, J.B., Sytze van Dam, P., & Drent, M.L. (2006). Effects of Growth Hormone Substitution Therapy on Cognitive Functioning in Growth Hormone Deficient Patients: A Functional MRI Study. Neuroendocrinology, 83 (1), 12-19. doi: 10.1159/000093337

Arwert, L.I., Deijen, J.B., Muller, M., & Drent, M.L. (2005). Long-term growth hormone treatment preserves GH-induced memory and mood improvements: a 10-year follow-up study in GH-deficient adult men. Hormones and Behavior, 4, 343 -- 349. doi:10.1016/j.yhbeh.2004.11.015

Arwert, L.I., Veltman, D.J., Deijen, J.B., Lammerstsma, A.A., Jonker, C., Drent, M.L. (2005). Memory performance and the growth hormone/insulin-like growth factor axis in elderly: A positron emission tomography study. Neuroendocrinology, 81(1), p31-40. doi: 10.1159/000084872

Arwert, L.I., Veltman, D.J., Deijen, J.B., Van Dam, P.S., Delemarre-Van de Waal, H.A., & Drent, M.L. (2005). Growth hormone deficiency and memory functioning in adults visualized by functional magnetic resonance imaging. Neuroendocrinology, 82(1), p32-40. doi: 10.1159/000090123

More objectivity is however expected from scientists, but their opinions also vary. Specifically, the opinions of those who support growth hormones and those who reject them are all derived from scientific evidence. This in turn means that the results of scientific research could be manipulated and influenced so that the findings are indicative of the desires of those who initiated the study. In this particular sense, the most pertinent situation is revealed by the beef and dairy producers, who hire their own scientists to lead the research process in the direction desired by them.

Aside from these situations however, the scientists who have conducted studies tend to link various health problems with the growth hormones. Some of the side effects to consuming products with residual matters from growth hormones include the onset of early puberty in girls, an increase in the risk of breast cancer, an increase in the risk of…...

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References:

Leonard, a., the story of stuff, the Story of Stuff Project,   / last accessed on February 21, 2012http://www.storyofstuff.org 

McLaughlin, a. 2011, the effects of growth hormones in food, Live Strong,   / last accessed on February 21, 2012http://www.livestrong.com/article/98816-effects-growth-hormones 

Artificial hormones, Sustainable Table, / last accessed on February 21, 2012http://www.sustainabletable.org/issues/hormones

EU scientists confirm health risks of growth hormones in meat, Organic Consumer Association, last accessed on February 21, 2012http://www.organicconsumers.org/toxic/hormone042302.cfm

The circulatory or cardiovascular system is responsible for moving nutrients, wastes and gases between body cells, transporting blood across the whole body and battling disease (Circulatory System). Its principal elements are the heart, numerous blood vessels, and blood.
The heart forms the circulatory system's core. This 2-sided, 4-chambered pump which distributes blood to various arteries comprises of the right and left ventricles, and right and left atria. The ventricles, situated within the heart's lower half, are responsible for pumping blood to the whole body (away from our heart), whilst the atria, situated within the heart's upper half are in charge of receiving blood from different parts of the human body. The right and left ventricles pump de-oxygenated and oxygenated blood, respectively; de-oxygenated blood is pumped to lungs while oxygenated blood is pumped to the remainder of the human body (smith, 2013). These 4 chambers are connected to one another by means…...

What is the most likely diagnosis? John is believed to be suffering from gigantism or acromegaly.
Symptoms of acromegaly
The term 'acromegaly' has its roots in the Greek terms for "enlargement" and "extremities"; these terms reflect one among the ailment's most commonly occurring signs of abnormally expanding feet and hands (Marieb & Hoehn, 2018a; 2018b). Swollen feet and hands typically manifest as an initial sign. Those suffering from the acromegaly notice changes in their shoe or ring sizes, especially shoe width. Slowly, changes in the bone begin to transform their facial features, with their lower jaw and brow protruding, spacing out of the teeth, and enlargement of their nasal bone (Colao et al., 2019).
Abnormal cartilage and bone growth frequently results in arthritis. Tissue thickening can trap nerves and result in the development of carpal tunnel syndrome (CTS) that in turn produces weakening and numbness of hands. Enlargement may also occur in the heart…...

Current Health Debate: Cow’s Milk and Human Consumption So many people grew up hearing repeated slogans and promotions from the dairy industry that were so consistent and repetitive, they seemed almost like a part of life. “Milk does a body good.” “Milk builds strong bones.” “Got Milk?” For decades, no one questioned the power of milk and the necessity of giving children milk. However, in the last ten or so years, the mentality has shifted and a product that was once unquestioned as a staple of human consumption, has now become controversial. This paper examines some of the pros and cons of the dairy industry and milk consumption from a strictly health perspective. The benefits of cow’s milk are examined lucidly, as are the criticisms that the dairy industry and milk consumption receive. Finally, each side’s argument is concluded succinctly, and recommendations for future protocol are presented for consideration.

Pros
One of the…...

Ergogenic Aid
When discussing and pondering the broader subject of steroids and other substances that aid the body in getting stronger and healthier, one word or term that is likely to come to mind is “anabolic”. However, the use and employment of steroids and supplements has multiple layers and types that must be considered. One of the other terms to consider is ergogenic. Regardless of the type of steroid or body aid, there is an intended and desired effect on performance. There is also the related, yet different, use of what is known as human growth hormone, or HGH. As with all medicines and treatments, there are medical risks when it comes to the use or abuse of steroids of any type, which would include ergogenic. While some people are prone to disavow and condemn the use of steroids and/or supplements across the board, here are a number of findings and…...

Endocrinology
AMAZING HORMONES

Counterbalance of Sugar and Fat Content between Insulin and Glucagon

Physical survival depends on the sustained availability and use of energy in the form of adenosine triphosphate or ATP from sufficient levels of a substance, called glucose (owen, 2001). The use of energy depends on the varying levels of activity. Hence, the amount of glucose needed for activity likewise varies each day. Too much or too little glucose is damaging to the body, hence the need for some system to regulate the availability of glucose. It must be present at the precise time and amount that it is needed in order to maintain what is called glucose homeostasis. Homeostasis is the tendency of the body to maintain internal stability and balance through the coordinated responses of body parts to stimuli or conditions (owen).

Insulin and Glucagon

The regulation of glucose availability begins with the pancreas, primarily by its production of the two…...

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BIBLIOGRAPHY

Biomed (2002). Insulin/glucagons. Brown University. Retrieved on November 25, 2013

from http://biomed.brown.edu/Courses/B1108/B1108_2002_Groups/pancstems/stemcell/insulin_glucagon.htm

Bowen, R.A. (2001). Hormones, receptors and control systems. University of Colorado.

Retrieved on November 25, 2013 from http://arbl.cvmbs.colostate.edu/hbooks/pathphys/endocrine/basics/index.html

e., their use of anabolic steroids (and whether they had ever been offered steroids), their involvement in power sports, appearance and eating problems, and problem behavior. Background information about the participants included their degree of urbanization, parental socioeconomic status and the region to which they belonged.
Analyses of the study's results show that the prevalence of steroid use among Norwegian youth was lower (lifetime use was 0.8% and 12 months prevalence was 0.3%) than in several other Western societies such as the U.S. (2.5% to 7%) and in Australia, Canada, Sweden and South Africa (2% to 3.5%). It also showed that AAS use was first and foremost associated with problem behavior (i.e., drug [marijuana] involvement and aggressive-type conduct problems). Its relation with power sports and appearance came in at second and third place respectively.

The study is, therefore, significant in highlighting the hitherto largely ignored area of problem behavior in steroid use.…...

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References

Admissions before BALCO grand jury detailed." (2004, December). ESPN.com. Retrieved on November 1, 2005 at  http://sports.espn.go.com/espn/news/story?id=1936592 

Anabolic Steroid Abuse." (2000, April). National Institute on Drug Abuse: Research Report Series. Retrieved on November 1, 2005 at  http://www.drugabuse.gov/PDF/RRSteroi.pdf 

Langone, J. (1995). Tough Choices A Book about Substance Abuse. Boston: Little, Brown and Company.

Miller, R.W. (1987, November). Athletes and Steroids: Playing a Deadly Game. FDA Consumer, 21, 16+.

Offered under the same roof are "consultative, diagnostic, and treatment services" which are stated to be provided "by board-certified practitioners in the fields of pulmonary medicine, otolarngology, family medicine and more." (2006)
Smith reports that the laboratories experiencing the most dramatic growth are two which are located the "farthest from the Hillsboro flagship" as they are located in two areas that were "formerly underserved." (2006) Smith additionally reports that the demand is stronger in the areas where the two fastest growing centers are located which supplies "plenty of fuel for expansion."

Smith states that the Sleep Health & Wellness NW is attempting to "fill a gap so that patients who previously were overlooked or not being reached or who fell through the cracks no longer are," she says. "We have no plans to open centers in areas where there are already quality sleep services programs. We only want to go into…...

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References

Inspiration! Sleep Study Results & Analysis (2006) Q&a with Ron Richard, senior vice president of strategic marketing initiatives at ResMed HME Business April 2006. Online at  http://www.hme-business.com/articles/55305/ 

Johnson, Duane, PhD (2008) Are you Really Managing Your Sleep Lab? The Business of Sleep. Focus Journal May/June 2008. Online at  http://www.foocus.com/pdfs/Articles/MayJune08/Duane.pdf 

Kay DC, Pickworth WB, Neider GL. Morphine-like insomnia from heroin in nondependent human addicts. Br J. Clin Pharmacol. 1981;11(2):159-169

MacFarlene, James (2009) the Painful Pursuit of Sleep. Sleep Review Journal Jan/Feb 2009. Online available at  http://www.sleepreviewmag.com/issues/articles/2009-01_07.asp

Animal Production: Biotechnology
Biotechnology has achieved some dramatic advances in recent years in both crop and livestock production. Food production results from the interaction of humans, animals, land and water; to help speed up this process, make it safer and more efficient, biotechnology has been involved. These include transferring a specific gene from one species to another to create a transgenic organism; the production of genetically uniform plants and animals (clones); and the fusing of different types of cells to produce beneficial medical products such as monoclonal antibodies. Today, biotechnology has a number of applications in livestock production. It is being used to hasten animal growth, enhance reproductive capacity, improve animal health and develop new animal products. In 1999, FFTC carried out a regional survey to draw up an inventory of technologies and products which have been developed using biotechnology for livestock production. Some of these are now being applied on…...

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Works Cited

Boyd, Emily. "Societal Choice for Climate Change Futures: Trees, Biotechnology, and Clean Development." Bioscience 60.9 (2010): 742-750. Environment Complete. EBSCO. Web. 30 Jan. 2011.

Devendra, Canagasby. "Sustainable Animal Production from Small Farm Systems in South East Asia." (London: Daya Publishing House, 1998).

Devendra, C., Thomas, M.A., and Zerbini, E. "Improvement of livestock production in crop- animal systems in rain-fed agro-ecological Zones of South Asia." (Kenya: International Livestock Research Institutie, 2000)

Kingiri, Ann. "Experts to the rescue? An analysis of the role of experts in biotechnology regulation in Kenya." Journal of International Development 22.3 (2010): 325-340. Environment Complete. EBSCO. Web. 30 Jan. 2011.

In Genentech, Hughes examines the remarkable rise of the Genentech company, which was an industry pioneer in the field of genetic engineering. The basic premise of Hughes’s book is that Genentech radically transformed biotechnology and even made a broader impact beyond the medical technology and science sectors. Themes Hughes addresses in Genentech include the business practices and processes needed to start a radical, innovative firm, particularly one with a business model based on science. Another major theme covered in Genentech is intellectual property, which is a major concern for the pharmaceutical industry, which eventually became heavily and inextricably entrenched in genetic science. Hughes also covers the theme of ethics: especially the conflicts of interest that can arise between the altruistic aims of academia and applied science and the commercial goals of a profit-driven enterprise.
Hughes offers an overview and history of the firm, which was created in 1976 by Herbert Boyer…...

aging gracefully. There are eight references used for this paper.
Introduction number of people are obsessed with fighting the affects of aging on the skin and finding ways to age gracefully. It is important to look at methods such as antioxidants, wrinkle fighters and nutritional supplements, as well as aging and tissue/muscle loss and interventions for slowing the aging process in order to gain a better understanding of treatments available.

Free Radicals

Free radicals are "highly reactive molecules with an unsatisfied electron valence pair. Free radicals are produced in normal and pathological processes, and are proven or suspected agents of tissue damage in a wide variety of circumstances including radiation, damage from environment chemicals, and aging (http://cancerweb.ncl.ac.uk/cgi-bin/omd?query=free+radicals)."

One of the main defenses against free radicals is the proper use of antioxidants.

Antioxidants

Researchers theorize that an "increase in some antioxidants - especially those applied to the skin - helps protect the skin from cell-damaging oxidants,…...

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Works Cited

Aging changes in organs - tissue - cells. (accessed 15 July 2004).  http://www.umm.edu/ency/article/004012.htm ).

Facenda, Vanessa L. Mass merchants face up to higher end skincare: improved formulations and higher quality products are attracting consumers to mass and drug for facial care needs. Retail Merchandiser. (2004): 01 January.

Free Radicals. (accessed 15 July 2004). http://cancerweb.ncl.ac.uk/cgi-bin/omd?query=free+radicals).

Hilton, Lisette. Intrinsic-extrinsic aging link: antioxidants applied to skin could prevent cell damage. Dermatology Times. (2002): 01 November.

On the whole, the Academy calls for the abolition of exemption laws and endorses initiatives to educate the public about the medical needs of children (Committee on ioethics)..
While AAP recognizes the importance of religion to people's lives, it also warns physicians and other health care professionals should put the health and welfare of children over religious considerations (Committee on ioethics 1997). It encourages pediatricians to respect parents' decision but not when their religious convictions interfere with medical care necessary to prevent harm, suffering or death. When this happens, pediatricians should seek the authorization of the court to override parental authority. If the threat to a child's life is imminent, the health care practitioner should intervene over parental objections. Securing court authorization should, however, be the last course of action. The health care practitioner should cooperate with the family in applying appropriate palliative care. Even when the securing of court…...

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Bibliography

Bender, Denise G. Do Fourteenth Amendment Considerations Outweigh a Potential State

Interest in Mandating Cochlear Implantation for Deaf Children. Journal of Deaf

Studies and Deaf Education: University of Oklahoma Health Sciences Center, 2004

Committee on Bioethics. Religious Objections to Medical Care. Volume 9 number 2