¶ … Liquid Dosage Forms
Rheology is the study of the deformation and flow of matter, focusing on "the viscosity characteristics of powders, fluids and semisolids" (Adesina "Rheology" 2). As such, it is this branch of physics that enables pharmacists to determine the proper mix and flow of materials used in the treatment of patients. Everything from the way in which a drug is packaged to how it is poured, squeezed, or injected must be considered by the pharmacist trained in the art of rheology prior to the drug's serving as an effective intervention. This paper will discuss that factors that would be considered when prepping a liquid dosage form and explain the relationships between these factors and the desired effects or outcomes that the drug form should possess.
There are various types of liquid dosage forms -- pharmaceutical solutions (liquid preparations that have chemical substances in them) and sterile dosage forms. Types of the former include syrups, elixirs, spirits, aromatic waters, tinctures, injections and fluidextracts (Adesina "Oral Solutions" 2). When prepping a liquid dosage form, numerous factors have to be considered -- for example, the nature of the form's flow (Newtonian or non-Newtonian), the purpose of the dosage, and the application. Newtonian flow forms consist of simple liquids -- water, alcohol, organic solvents (Adesina "Rheology" 18). Non-Newtonian flow forms comprise the majority of pharmaceutical solutions and these solutions consist of three different classes: pseudoplastic flow, dilatants flow and plastic flow.
Pseudoplastic flows are used in liquid dosage forms when colloidal systems are required (typically polymer-based solutions) -- i.e., solutions that become more fluid the more they are stirred or shaken -- an event known as shear thinning (Adesina "Rheology" 21). Such solutions are necessary when the pharmaceutical solution is desired to retain the solution's integrity over time.
Dilatants flows is the opposite of pseudoplastic flows in that these are solutions that are fluid when free of stress but that become more viscous when they are shaken. They are, in other words, shear thickening solutions. The deflocculated particles...
Such flows are also desirous for pharmaceutical applications that have limited shelf-life periods or in solutions that require aqueous additives (because in aqueous solution that are too unstable) in order to facilitate ingestion (Adesina "Oral Solutions" 13).
These three types of flow describe the various pharmaceutical solutions that are used by consumers for diverse interventions -- from the easing of
symptoms of cold or flu to
healing (burns, cuts, rashes, etc.). Depending on the type of form that is preferred by the consumer -- spray (aerosol), cream, or ingestible -- the manufacturers of the pharmaceutical solution will have to consider the type of flows that are conducive to the end product and then formulate the product's ingredients accordingly.
To prepare a liquid dosage form, one of the key factors to consider would be whether or not an antimicrobial agent such as alcohol will need to be added to the solution. Topical solutions or tinctures often utilize alcohol for this reason in their liquid dosages (Adesina "Oral Solutions" 35). Other considerations that must be made depend on the type of solution in question.
For instance, co-solvents are used when needed to support stability and/or solubility. Sometimes preservatives are added if the solution is not self-preserving. For a liquid dosage that is to be sprayed, the solution must be broken up into small particles that are conducive to a Newtonian flow. Antiseptics, local anesthetics, and skin protectants are all types of liquid solutions that would benefit from a spray type of application. Fungal infections, such as athlete's foot or ringworm (jock itch) can be treated in a similar manner.
Likewise, the manner in which the liquid form is to be applied is a consideration that the drug manufacturer must make. If the solution is to be applied in medicinal drops, a small bottle with an applicator would be the preferred packaging, for example. If the liquid dosage is to be sprayed, a spray bottle or medicinal atomizer would be the desired packaging.
Pharmacists must also consider use. Sterile dosage forms, for instance, require special treatment and "must be exceptionally pure and free from physical, chemical and biological…
