5+ documents containing “progeria”.
Progeria is a somewhat mysterious illness that affects children all around the globe. The rapid ageing of individuals that suffer with the condition has intrigued scientist and researchers for decades. Because the disease is so rare, very little is known about the condition.
The purpose of this discussion is to explore the various aspects of this condition. e will begin by defining Progeria. Our discussion will also explore the characteristics and causes of the condition. Finally, we will discuss recent developments that may aid in the prevention and treatment of the disease.
The Progeria Research Foundation defines Progeria as, "a rare genetic condition characterized by an appearance of accelerated aging in children." ("hat is Progeria")
An estimated 1 in 4 million children suffer with the condition. The disease affects both sexes and all races equally. The disease is usually diagnosed in the two years after the birth of the child.
Currently, there are….
Dyer, Christopher A.E., Sinclair, Alan J. The premature ageing syndromes: insights into the ageing process. Age and Ageing. Issue: Jan, 1998
Gene is discovered for rapid aging disease in children." 17 April 2003. CNN News. April 28, 2003. http://www.cnn.com/2003/HEALTH/conditions/04/17/aging.gene/
Introduction." 2003. Hutchinson-Gilford Progeria Syndrome. April 28, 2003. http://www.hgps.net/
What is Progeria." 2003 The Progeria Research Foundation. April 28, 2003. http://www.progeriaresearch.org/whatIs/whatis.htm
When DNA is damaged, cells can react through cell cycle checkpoints which allows repair to begin before further division can occur. There is also the prokaryotic SOS response which changes gene expression in bacteria as a result of DNA damage. This response is regulated by the production of certain proteins. Moreover, eukaryotic cells also react to DNA damage through producing proteins that begin the process of DNA repair.
8. Mice are often the favored mammalian in the testing of aging interventions. This is often because of the fact that there are many mice easily available for testing but also the fact that "generation time is short" (Yuan et al. 2011). Essentially, the aging process and testing in interventions can be done on a much shorter time scale then with tests using monkeys.
9. Enzymes may change the transcription patterns of a cell by adding chemical groups to histone proteins. This process….
Books. W.R. Clark. (2009). Human genetic diseases that mimic the aging process. Progeria? The Progeria Project Foundation. Web. http://www.progeriaproject.com/progeria/mimic.htm
Conboy, I.M., Conboy, M.J., Wagers, a.J., Girma, E.R., Weissman, I.L., & Rando, T.A. (2005). Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature, 17(433), 760-764.
Conti, Matteo. (2008). The Selfish Cell: An Evolutionary Defeat. Springer Publishing.
McClintock, D., Ratner, D., Lokuge, M. (2007). The mutant form of Lamin a that causes Hutchinson-Gilford Progeria is a biomarker of cellular aging in human skin. PLOS One, 2(2). Web. http://www.plosone.org/article/info:doi/10.1371/journal.pone.0001269
4. How does Luther and Calvin's view of moral evil differ from that of Catholicism?
The classical Christian approach to the dilemma of moral evil has been that people are abusing the freedom of choice given to them by their creator. With free will and the ability to choose between good and evil actions, people who exercise the wrong choices can create moral evil, which impacts others. The Catholic Church essentially takes this approach to evil. To understand their approach, one must understand the concept of original sin. When Adam and Eve were in the garden, they were created in the image of God, but with a presumably much more limited intellect than modern humans. They were forbidden to eat the fruit of the tree of knowledge, because it would give them moral reasoning, thus making them closer to God. However, they chose to eat of this fruit, which distanced them….
Mechanisms of Interspecies Senescence
The nature of human experience has impelled us throughout time to ponder mortality and immortality. Today, biologists are actually beginning to provide answers to what were formally purely philosophical and religious questions. hat follows is a discussion of the mechanisms underlying biological mortality and immortality, otherwise known as senescence.
In terms of biological immortality, the cnidarian Hydra stands out. Some hydra species have been shown to survive indefinitely under laboratory conditions, by relying on asexual reproduction (Bosch, 2009, p. 484). Bosch suggests that asexual budding confers an evolutionary advantage to Hydra, because it provides a mechanism for generating enough offspring to survive competition and predation pressures from other species. Rapid asexual budding, in turn, requires cells to proliferate continuously. In other words, the stem cell populations in Hydra, which give rise to the various cell types required to make a complete organism, appear to be immortal. This is….
Bosch, Thomas C.G. (2009). Hydra and the Evolution of Stem Cells. Bioessays, 31, 478-486.
Metcalfe, Neil B. And Alonso-Alvarez, Carlos. (2010). Oxidative stress as a life-history constraint: The role of oxygen species in shaping phenotypes from conception to death. Functional Ecology, 24, 984-996.
Rando, Thomas A. And Chang, Howard Y. (2012). Aging, rejuvenation, and epigenetic reprogramming: Resetting the aging clock. Cell, 148, 46-57.
Death and Dying (general)
Progeria is a somewhat mysterious illness that affects children all around the globe. The rapid ageing of individuals that suffer with the condition has intrigued scientist and researchers for…Read Full Paper ❯
Death and Dying (general)
When DNA is damaged, cells can react through cell cycle checkpoints which allows repair to begin before further division can occur. There is also the prokaryotic SOS response…Read Full Paper ❯
Mythology - Religion
4. How does Luther and Calvin's view of moral evil differ from that of Catholicism? The classical Christian approach to the dilemma of moral evil has been that people are…Read Full Paper ❯
Death and Dying (general)
Mechanisms of Interspecies Senescence Senescence The nature of human experience has impelled us throughout time to ponder mortality and immortality. Today, biologists are actually beginning to provide answers to what were…Read Full Paper ❯