History of cardiovascular disease
Recent advances in genetic research methods have uncovered a large number of cardiovascular disease (CVD) susceptibility loci. Despite contributing to CVD prevalence, much of the inter-individual variation is not due to genetic factors. Mendelian CVD-associated traits tend to have a large effect, but occur so rarely that they contribute little to overall variation in CVD prevalence. In addition, common CVD-associated traits have small effect sizes and likewise contribute little. However, genetic CVD risk factors do contribute significantly to early onset disease and disease severity, if the genetic analysis is limited to distinct morphological locations in the proximal cardiovascular system. These research findings suggest CVD is a mosaic of multiple risk factors influencing disease manifestation by location.
Evidence-Based Practice Faith MS, Van
The evidence presented in the report absolutely supports the conclusion reached by the team of authors. The researchers go to great lengths to determine how "Families play a critical role in the development and maintenance of eating and activity behaviors in youth, and parents have considerable influence over what, when, where and how children eat. As parent involvement2 and modeling of healthy behaviors3 have been identified as crucial components of effective interventions, most child weight control programs are family-based. Moreover, parent weight loss predicts child weight loss,4 suggesting that