The idea that animal fat consumption causes heart disease is perhaps the most controversial component of the standard preventative advice given to reduce heart disease. This association is based upon the research of Ancel Keyes, who compared heart disease rates in the United States, Canada, Australia, England, Italy, and Japan and found that lower rates of heart disease were manifested in countries with less saturated fat consumption. However, there are many examples of tribes that ate diets high in animal fats and protein yet had low rates of heart disease until exposed to a Western diet: the lifestyle practices of the industrialized world clearly seems more apt to contribute to heart disease but exactly how remains uncertain. There is a complex interplay of genetics and other metabolic factors in the development of atherosclerosis (Teicholz 2007).

Total cholesterol alone has a limited value in predicting the tendency to develop heart disease: the….

Though this work focuses specifically on the risk factors of atherosclerosis for A patients and how to better identify them prior to clinical presentation of atherosclerosis the work is also insightful in that it builds a case for the connection between A clinical presentations and atherosclerosis, in general. To move forward from this progressive idea is the fact that research has indicated that there is an even greater connection between A patients and increased Carotid intima-media thickness (cIMT), which has served as a preclinical predictor in non-A patients for cardiovascular events, but has now been shown to be even greater in progressive severity in A patient, but especially in those with A symptomology that has lasted longer than 20 years. This high grade of cIMT is also an indication of increased inflammation, in addition to increased plaque deposits in the carotid arteries.
A cIMT has previously been found to be….

Pathogenesis of Atherosclerosis
Artery diseases are of immense concern to medical researchers due to the cause and effect relationship shared with heart disease and cardiovascular mortality. Atherosclerosis is one of the diseases earning such focus from researchers because of its multifactorial nature, and its period of development which typically occurs years before clinical symptoms are apparent. Atherosclerosis is a disease of the arterial wall that promotes several common causes of cardiovascular mortality, including myocardial infarction and cerebrovascular disease (Channon 2002). The term "atherosclerosis" was traditionally used to describe an abnormality in lipid metabolism, an end-stage degenerative disease, and vessel stiffening. Further studies have caused a rapid increase in knowledge of the pathogenesis of atherosclerosis, and suggest the inciting event of atherosclerosis is more likely an inflammatory event which occurs years before evidence of the disease clinically manifests (Crowther 2005).

Cellular and molecular mechanisms that underlie atherosclerosis demonstrate the roles of the endothelium,….

3. Growth factors can induce apoptosis by binding to their respective receptors (TKs). When activated, TKs in turn activate the as, af, MEK, MAPK, MKK, EK, Fos, JNKs, and Jun pathway, which can lead to the induction of AF via gene upregulation. AF in turn suppresses mdm2, a suppressor of p53 activity. The resulting increase in p53 activity can induce Bax, Mt, and thus apoptosis.

4. Adenomatous familial polyposis is caused by a truncated APC protein, which results from inherited mutations in the APC gene (Segditsas and Tomlinson, 2006). However, the activity of the wild-type or normal APC allele is usually sufficient to maintain tumor suppressor activity. For this reason, and because the wild-type allele is often found to have acquired somatic mutations, it is assumed that both alleles must be mutated before tumors can form. The vast majority of mutations found in colorectal tumors have retained 0 to 3 20-amino….

Metabolic syndrome is significant for our patient for several reasons. As we have noted, the syndrome is associated with a higher risk of cardiovascular disease. Those patients who have metabolic syndrome tend to develop coronary atherosclerosis at a higher rate than those who have coronary risk factors alone. Obesity increases the risk of metabolic syndrome but so does pre-obesity, or BMI ranging from 25-30. Women who have been diagnosed with polycystic ovarian syndrome are noted to be at increased risk of hypertension, dylipidemia, insulin resistance, impaired glucose tolerance and Type II diabetes. Because of all these comorbidities, women with PCOS also tend to be at greater risk for patients with subclinical carotid atherosclerosis, especially in the premenopausal population (Talbot, et al., 2000). For these same reasons, women diagnosed with PCOS have a 5 fold increased risk for the development of complications of coronary and cerebrovascular atherosclerosis.

Mrs. Stiller has many concerns….

New Suppliers of Health Supplements
A promising new addition to the company's current line of health supplements was identified during a recent trip to Bangkok, Thailand, to meet suppliers of a promising antioxidant, coenzyme Q10. A growing body of research suggests this antioxidant is effective in improving cardiovascular function and may also be useful in alleviating the symptoms of angina pectoris, cardiac arrhythmia, high blood pressure, moderate gingival disease, congestive heart failure, dilated cardiomyopathy and severely impaired immune systems. Based on the documented efficacy, high quality and low costs of the health supplement offered by this vendor, this report provides the background and an overview of the supplier, a description of the health supplement, and current applications for coenzyme Q10. A summary of the business trip and meeting with the company's president is followed by recommendations and a brochure illustrating various aspects of the product.

esults of Business Trip to Thailand

Background….

Carl must be psychologically prepared to make such changes, however. Thus, as well as taking Carl's blood pressure and submitting a blood sample to have his cholesterol screened (getting his blood glucose level assessed, even though there were no problems in the past with this reading might also be wise), the nurse should try to obtain a full assessment of Carl's lifestyle. When and what does he eat? What are his work habits? His sleep habits? Has anything changed recently in his life? All of these factors could make a potentially meaningful impact upon both the test results and the eventual prescription for Carl to improve his health.
Carl is still very young to run the risk of having a heart attack: the risk of having a heart attack increases dramatically after age 65) so engaging in positive changes now is wise and prudent (Heart health screening, 2013, AHA). It….

Vascular Disease
andy Jackson

Geriatric Nursing

The disease known as Peripheral Vascular Disease (PVD), according to the American Heart Association (AHA, 2004), involves the blood vessels "outside the heart and brain." This disease refers to a narrowing of those vessels that carry blood to one's leg and arm muscles.

In particular, the AHA states that there are two forms of PVD: one is "Functional Peripheral Vascular Disease," and the other is "Organic Peripheral Vascular Disease." The first, Functional PVD, does not allude to actual defects in the structure of the blood vessel, but rather refers to "short-term effects" caused by cold temperatures, stress caused by emotions, smoking, or handling machinery that vibrates powerfully.

The second form of PVD - "Organic" - is actually caused by "structural changes" in blood vessels. These changes may be inflammation, tissue damage, or the buildup of fatty substances in the arteries, called "atherosclerosis" - which restricts good blood flow….

M.K., a 45-year-old female who has a history of Type II diabetes mellitus and primary hypertension. In addition to this, M.K. is overweight and persists with a poor diet. The patient has also been smoking for the past 22 years, and has recently been diagnosed with chronic bronchitis. Current symptoms include chronic cough, which tends to be more severe in the mornings and productive with sputum, light-headedness, distended neck veins, excessive peripheral edema, and increase urination at night. The patient is currently on several medications including Lotensin and Lasix for the hypertension, along with Glucophage for the Type II diabetes mellitus. From an analysis of M.K.'s lab results, this report will offer clinical findings and treatment recommendations, as well as suggestions for what other conditions M.K. may be at risk for given her health history, lifestyle, and lab results as follows:
Vitals

BP

158/98 mm Hg

CBC

Hematocrit

57%

Glycosylated hemoglobin (HbA1c)

Arterial Blood Gas Assessment

PaCO2

52 mm….

When evaluating completions rates involved with PWA, radial tonometry had a 66% and carotid tonometry had a 99%. The radial tonometry was determined to be easier on the patient.
Laser Doppler Imaging (LDI)

Laser Doppler Imaging (LDI) has increased significance over previous single probe techniques. lood flow is no longer measured at a single site but between an area and the LDI due to being non-contact cannot interfere with the final results. LDI is a 1mm laser beam that uses a mirror to scan in two dimensions. A small amount of light penetrates the skin; the depth depends on wavelength and absorption, of area scanned and interacts with cells and tissues. Speed and density of moving cells determine the signal sent to detector. Discovery Technology International defines the amount of tissue measured as:

we have estimated that for well-perfused tissue such as muscle, the mean sampling depth for our probes is in….

2010; Chorny et al. 2010). This research is still quite new, however, and the question remains as to whether or not nanoparticles can truly serve as a replacement for stents by prohibiting plaque growth through a variety of means, including more targeted and longer-range delivery of pharmaceutical substances that destroy such build-ups and inhibit plaque deposits from forming. The efficacy of this approach has already been preliminarily demonstrated, but the long-term viability and safety of this intervention method as well as attendant risks have not yet been fully determined (Chan et al. 2010; Chorny et al. 2010).
IV. Motivation for esearch

Despite the numerous advancements that have been made in treating plaque build-up in arteries and the general treatment and control of other cardiac issues, coronary artery disease is still the leading cause of death in North America and is a significant problem in other parts of the world, as well….

1958

After studying the cardiovascular effects of various catecholamines, Moran and his research partner, Perkins, are published in the same journal as Ahlquist arguing "that DCI's activity belonged to Ahlquist's 'beta-adrenergic' type, and coined the term 'beta-adrenergic blocking drug', later shortened to 'beta-blocker'"

1959

Sir James Black joins the cardiovascular team at Imperial Chemical Industries, Ltd., reads Moran's research and realizes the possibilities of synthesizing an analog to DCI that would be clinically useful.

1959

Black's ICI report contradicts Waring's arguing that the "altered fat metabolism with associated changes in blood coagulability interact, permissively, with sympathetic neurohumoural stress responses to produce fatal damage."

1962

Black synthesizes propranolol (Inderal)

1963

ICI launches Black's first beta blocker treatment -- pronethalol (Alderlin).

1964

The first clinical studies are conducted for the use of proopranolol.

1965

ICI launches propranolol, the replacement for propranolol as it was found to cause thymic tumors in mice.

1966

Propranolol is first marketed in the U.S.

1967

Lands identifies a variety of models of sensitivity to….

Fish Oil Supplements Great for the Heart," discusses the benefits of fish-oil supplements in controlling atherosclerosis, which can lead to heart disease. Studies show that fish-oil helps break down triglycerides, that can cause atherosclerosis, and people who exercise regularly show the most benefits from taking fish-oil supplements. The research used test subjects, and a variety of situations to test results, and showed that those who exercised and took fish-oil could reduce their triglyceride levels by 50%. This article indicates that fish-oil supplements could replace some other drug therapies for heart disease, and that it is a good idea to begin and exercise program and take fish-oil supplements if you want to reduce your risk of heart disease. I do not take fish-oil now, but I think I will start.
The second article, "Heart of the Matter," discusses several different supplements that are supposed to help prevent heart disease, including fish….

Not only that, the results of eating badly is harmful. Holland and Barrett magazine reports: "If your diet isn't as balanced as you'd hope for, there's a chance you could be missing out on L. Trytophan - an important amino acid that plays a vital role in the production of brain chemicals." If one's diet is lacking it, the safest way to get this supplement is in the form of 5-HTP - a natural compound that the body produces from L-Trytophan. 5-HTP is believed to help the body produce serotonin, a chemical that regulates mood, sleep and other brain-related functions. (Pearce, 1999)
In aging people who seem to have no appetite, there actually may be a sensory dysfunction, which keeps that person from enjoying food and other things that are sensed through taste and smell. Susan S. Schiffman, Ph.D. pointed out that in the elderly these senses are not entirely….

Obesity is a serious social problem in America. The effects of obesity in childhood are well documented in both the social science literature and medical journals. During the last 30 years, the percentage of obese children between the ages of 6 and 11 has risen 200% while the percentage of obese children between 12 and 19 has tripled (CDC, Preventing Childhood Obesity, 2010). Obesity in the nited States has increased among all cohorts and ethnicities, spans across generations, and is not limited to income or educational levels. However, the incidence of obesity among African-American women is of particular concern given the prevalence and severity of the issue in America.
Public health issue

More than two-thirds of Americans are now obese or overweight (Ogden et al., 2010).

Rates of adult obesity now exceed 20% in 49 states and D.C and 25% in 40 states. By way of comparison, in 1991, rates did not exceed….