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The first noticeable result was at first disappointing but turned around later in the trail. At first the rsaL mutation did not have any effect on the production of 30C12-HSL nor on lasl transcription, but it began to appear later in the logarithmic phase of propagation at which time the 30C12-HSL production along with Plasl activity reached homoeostasis in the wild strain while continuing to increase rsaL in the mutant strain of the pathogen. However the sturdy found that:
The increase in rsaL level coincides with the point at which the production of 30C12-HSL diverges in the parent and mutant strains. This is consistent with the conclusion that Rsal induction by 30C12-HSL results in sufficient Rsal to keep 30C12-HSL production at a steady level, balancing the positive feedback action on lasl expression (Rampioni, et. al. 1558)
From this the authors concluded that Rsal is the key molecule that effects…
Rampioni, Giordano, Martin Schuster, Everett Peter Greenberg, Iris Bertani, Marco Grasso, Vittorio Venturi, Elisabetta Zennaro, & Livia Leoni. "RsaL provides quorum sensing homeostasis and functions as a global regulator of gene expression in Pseudomonas aeruginosa." Molecular Microbiology. (2007) 66.6 1557-1565
Molecular Basis Glanzmann Thrombasthenia
An investigation of the molecular basis of Glanzmann Thrombasthenia using Polymerase Chain Reaction (PCR)
The objective of this project is to investigate the molecular basis of Glanzmann Thrombasthenia (GT) using polymerase chain reaction. There have been many mutations discovered in GT patients over the years in many studies. Thus using PCR to genotype patients is one of the most effective ways of discerning the genetic basis of the disease. The purpose of these sets of experiments is to determine if a mutation on the ITG?3 promoter, which occurs in a certain percentage of Glanzmann Thrombasthenia (GT) patients, can be reversed through site directed mutagenesis and if normal platelet functioning can resume. Normal platelet functioning will be assessed through detecting promoter region binding to the myc transcription factor through chromatin immunoprecipitation assays, also known as ChIP assays. e anticipate that the myc transcription factor will have enhanced…
D'Andrea, G. et al. (2002) Glanzmann's Thrombasthenia: Identification of 19 New Mutations in 30 Patients. Thromb Haemost 87: 1034 -- 42.
Morel-Kopp et al. (1994) Human platelet alloantigen typing: PCR analysis is not a substitute for serological methods. Transfusion Medicine, 4: 9-14.
Newman, P.J. et al. (1991) The molecular genetic basis of Glanzmann thrombasthenia in the Iraqi-Jewish and Arab populations in Israel. Proc. Natl. Acad. Sci. USA 88: 3160-3164.
Nurden, A.T. (2006) Glanzmann Thrombasthenia. Orphanet Journal of Rare Diseases 10:1.
Expression Profiling of a Novel Protein
A new transcription unit was discovered while working with transfected murine BAC clones, because a novel spot appeared on a 2-dimensional protein gel. Through a process of expression subcloning from the BAC clone, the transcription unit that generated the novel peptide was located. This finding was back validated by sequencing the protein contained in the 2-D gel piece using N-terminal Edman degradation and mass spectroscopy (osenfeld, Capdevielle, Guillemot, and Ferrara, 1992; Hellman, Wernstedt, Gonez, and Heldin, 1995).
This transcription unit happens to be encoded within a multi-gene locus that is coordinately regulated in a tissue-specific and developmental manner. Since the laboratory is already heavily invested in characterizing the gene regulatory mechanisms that control this locus, and the downstream roles of the gene products, understanding the expression pattern of this novel gene may be important to ongoing research efforts.
Determination of mNA patterns of expression…
Reference gene selection for real-time RT-PCR in regenerating mouse livers. Biochemical and Biophysical Research Communications, 374, 106-110.
Xu, L., Ma, X., Cui, B., Li, X., Ning, G., and Wang, S. (2010). Selection of reference genes for qRT-PCR in high fat diet-induced hepatic steatosis mice model. Molecular Biotechnology, Published online ahead of print December 24, 2010.
Yan, F., Wu, X., Crawford, M., Duan, W., Wilding, E.E., Gao, L. et al. (2010). The search for an optimal DNA, RNA, and protein detection by in situ hybridization, immunohistochemistry, and solution-based methods. Methods, 52, 281-286.
Yokoyama, W.M. (2006). Production of monoclonal antibodies. In J.P. Robinson, Z. Darzynkiewicz, R. Hoffman, J. Nolan, P. Rabinovitch, and S. Watkins (Eds.), Current Protocols in Cytometry (Appendix 3J). Wiley Online Library. Retrieved February 6, 2011 from http://onlinelibrary.wiley.com/doi/10.1002/0471142956.cya03js37/pdf
The Science of molecular size machines and its engineering designs and constructions until late 1980s were not considered practicable. Nanotechnology, according to the leading exponents of that time were neither feasible nor viable, due to the fact of total structural difference of the constituent of nano-molecular device i.e. Atoms from the mechanical objects of every day life. The essential components of engineering mechanics i.e. cogwheels, gears or motors could not be imagined to have formed by means of atoms, that are characterized by fuzzy and unsubstantial contents having no definite location position. Edwin Schrdinger, a leading quantum theoretician, regarded the particles as not permanent entity but an instantaneous event and derived the conclusion that atoms could no longer be regarded as "identifiable individuals." Werner Heisenberg, with extreme pessimism described atoms as "a world of potentialities or possibilities" rather than "of things and facts." (Is the future nano?)
Bio-Molecular Motors Research in Japan. Asian Technology Information Program (ATIP), 2002 Retrieved from www.atip.org/ATIP/NANO/reports/atip02.006.pdf. Accessed on 26 April, 2004
Chen, Andrew. The Ethics of Nanotechnology. Retrieved at http://cseserv.engr.scu.edu/StudentWebPages/AChen/ResearchPaper.htm. Accessed on 26 April, 2004
Frischauf, Norbert. Nanotechnology and Medicine. 02, May, 2002 Retrieved at http://www.itsf.org/resources/factsheet.php?fsID=175Accessed on 26 April, 2004
Jogi, Vikram. The Ethics of Nanotechnology. Retrieved from www.cs.wmich.edu/~elise/courses/cs603/Presentation/Nanotech_Presentation_022304.ppt Accessed on 26 April, 2004
The failure of human hamster fusion in the presence of anti-human izumo antibody clearly showed that Human izumo protein is essential for fertilization.
This study however has raised some new questions. The difference in fertilization capacities between wild type and Izumo +/- type was not clearly discussed. Also, the fact that ICSI of izumo -/- produces twice as many litters as did the izumo +/- type implicates the possible role of other proteins, the expression of which is affected by the allele. That is to say that the mutant knockout sperm might have up-regulated or down regulated the expression of this unknown protein which may have aided the fertilization process as indicated by the statistics. [Katie Winter] contraceptive vaccine targeting the sperm is very much in prospect but much work is yet to be accomplished. A CD46 gene knockout as tried by the author in an earlier study did not…
Wang, De Gang, Huang, Tian Hua, Xie, Quing Dong, an, Gang, (Mar 2008), 'Investigation of Recombinant mouse sperm protein Izumo as a potential immunocontraceptive agent', American Journal of Reproductive Immunology, Vol 59, No 3, pg. 225-234
Inoue N, Ikawa M, Nakanishi T, Matsumoto M, Nomura M, Seya T, Okabe M. (2003) Disruption of mouse CD46 causes an accelerated spontaneous acrosome reaction in sperm. Mol Cell Biol. 23: 2614 -2622
Cho C, Bunch DO, Faure JE, Goulding EH, Eddy EM, Primakoff P, Myles DG. (1998), 'Fertilization defects in sperm from mice lacking fertilin beta'. Science.281: 1857 -1859
Naz RK, Leslie MH, Zhu X. (2001) 'Inhibition of murine sperm-oolemma binding by antibodies to an oocyte membrane (OM) antigen: implication in contraceptive vaccine development'. Am J. Reprod Immunol. 45: 52 -61.
"Construction of the mobilizable plasmid pMV158GFP"
"Construction of the mobilizable plasmid pMV158GFP" is an article that describes the construction of a new, mobilizable plasmid, based on the pMV158 plasmid; but containing the gene which codes for green fluorescent protein (gfp) and is controlled by a maltose inducible promoter (Pm). The new pMV158GFP plasmid allows for bacteria which contain it to glow green under UV light, indicating whether or not the plasmid has been incorporated into, or mobilized, the Gram-positive bacteria. This new plasmid will allow for a better understanding of the processes and development of infectious bacteria in their natural environment.
Plasmids are circular, self-replicating pieces of DNA which are used to insert other pieces of DNA into cells and can be extremely useful in biological research. Nieto and Espinosa use one particular plasmid, pMV158, to create a new one which is designed for their specific needs. They intend…
Nieto, Concepcion, and Manuel Espinoza. (2003). Construction of the mobilizable plasmid pMV158GFP, a derivative of pMV158 that carries the gene encoding the green fluorescent protein. Plasmid 49: 281-285.
Intrinsically Photosensitive etinal Ganglion Cell
ecent studies on biological anatomy of the eye discovered an additional photoreceptor within the mammalian eye. The cells discovered mediate the primary non-image visual activities with the vision system. The functioning of these cells aids in various significant processes including the regulation of the papillary reflex activity in response to light, as well as, the circadian photo entrainment. These cells, called the intrinsically photosensitive retinal ganglion cells respond to more than the absolute light. The ipGCs have a unique feature of activity, as they differ from the usual photoreceptor cells of cones and rods. The rods and cones mediate on the vision of images by signaling the contrasts in light after adaptation. Interestingly, the ipGCs also do adapt to light contrast. The cells show sensitivity to flash of light, as is the case with other photoreceptors. The factor of action of the intrinsically photosensitive ganglion…
1. Bellintani-guardia, B., & Ott, M. (2002). Displaced retinal ganglion cells project to the accessory optic system in the chameleon (chamaeleo calyptratus). Experimental Brain Research, 145(1), 56-63. doi: http://dx.doi.org/10.1007/s00221-002-1091-z
2. Ben Simon, G.,J., Hovda, D.A., Harris, N.G., Gomez-Pinilla, F., & Goldberg, R.A. (2006). Traumatic brain injury induced neuroprotection of retinal ganglion cells to optic nerve crush. Journal of Neurotrauma, 23(7), 1072-82. doi: http://dx.doi.org/10.1089/neu.2006.23.1072
3. Engelund, A., Fahrenkrug, J., Harrison, A., & Hannibal, J. (2010). Vesicular glutamate transporter 2 (VGLUT2) is co-stored with PACAP in projections from the rat melanopsin-containing retinal ganglion cells. Cell and Tissue Research, 340(2), 243-55. doi: http://dx.doi.org/10.1007/s00441-010-0950-3
4. Henderson, D., & Miller, R.F. (2003). Evidence for low-voltage-activated (LVA) calcium currents in the dendrites of tiger salamander retinal ganglion cells. Visual Neuroscience, 20(2), 141-52. Retrieved from http://search.proquest.com/docview/198275379?accountid=458
altenative appoach to Computeized Tomogaphy in foensic pathology.
Thomsen, A.H., Juik, A.G., Uhenholt, A.G., Vesteby, A. (2009).
Jounal: Foensic Science Intenational.
Publication Infomation: 2008, 183, 87-90.
The main pupose of this aticle is to see whethe o not CT scans ae necessay as a means of augmenting autopsies. The eseach question is: do the benefits of CT scans match the effot equied to implement this technology? Thee is no hypothesis fo this aticle; the authos wee cetainly non-patisan in thei appoach and assumptions. The sample was 20 dead bodies (including 15 males) with CT scans pefomed by the Depatment of Radiology at Aahus Univesity Hospital. I eviewed this aticle to ascetain the elevance of CT scans to foensic pathology.
Abstact: This aticle denotes the boons and the detiments associated with using CT scans as compaed to, and augmenting the usage of conventional autopsies fo foensic pathology. Oiginal eseach…
references to certain applications dating back to the 1980s. In this respect the article was extremely comprehensive in its scope, although perhaps it may have been better suited focusing on more contemporary applications. Still, for the variety of knowledge it covered and the degree of insight it shed, it is certainly an excellent starting point for research into this field, and helps to synthesize the various points of relevance of the other articles explicated within this assignment.
Bruised witness: Bernard Spilsbury and the performance of early twentieth-century English forensic pathology
Author(s): Burney, I., Pemberton, N.
Journal: Medical History
Publication Information: 2011, 55, 41-60.
detection of the Borna disease virus relating them to the epidemiology.
The first cases of Borna disease were descried in the 17-19th century in Southern Germany. It was discovered to e a fatal disease affecting the neurological systems of horses and sheep, (Ludwig et al., 1985; Durrwald, 1993) causing ehavioral and neurological symptoms. It was proven to e caused y a 2003]
Today it is eing realized that the scope of the disease is not limited to just a few countries as was previously elieved ut encompassed the world. Also it was realized that far from affecting just horses and sheep as was originally thought virus, the Borna Disease Virus (BDV) in the early 1900's y Zwick and his team in Giessen Germany. [Author not availale, it in fact affected other animals and even human eings.[Staeheli, Sauder; Schwemmle, et al., 2000]
Research into the epidemiology and pathogenesis of the BDV…
bibliography. Journal of Veterinary Medicine Series B. 44, 147-184.
3.Staeheli, P., Sauder, C. Schwemmle, M. et al.,. Epidemiology of Borna disease virus, J Gen Virol 81: 2123-2135
4.Author not available,  Diagnostic Methods In Virology, accessed at http://virology-online.com/general/Tests.htm
5. Nakamura, K., Takahashi, H., Shoya, Y., Nakaya, T., Watanabe, M., Tomonaga, K., Iwahashi, K., Ameno, K., Momiyama, N., Taniyama, H., Sata, T., Kurata, T., de la Torre, J.C. & Ikuta, K. . Isolation of Borna disease virus from human brain. Journal of Virology 74, 4601-4611.
6. Zimmermann, W., Durrwald, R. & Ludwig, H. (1994). Detection of Borna disease virus RNA in naturally infected animals by a nested polymerase chain reaction. Journal of Virological Methods 46, 133-143
Genomes and Comparative Genomics
Over the last decade we have achieved rapid strides in the field of genetic engineering. The study of molecular biology has been fairly advanced mainly aided by the unprecedented growth in information technology. Today bio-informatics has opened new vitas for us and we are already progressing in investigating and in the comparative study of genomes. This has shed new light up on our knowledge of the evolutionary process and the important concepts such as protein folding and selective expression, which have so far eluded our understanding, are beginning to unfold. Let us have a brief overlook of the subject.
The Role of DNA
One of the greatest achievements of the twentieth century has been the unraveling of the mysteries behind the DNA and the mechanism of protein synthesis. Genes are the fundamental units of biological inheritance and are made up of Deoxyribonucleic acid (DNA). Genes are…
Mullis, KB (1990), Scientific American, April 1990, 56
Hecht, J., 19 May 2003, Chimps are human, gene study implies, New Scientist
Cohlan, A., 30 May 2002, "Just 2,5% of DNA turns mice into men," New Scientist
TK Attwood & DJ Parry Smith, "Introduction to bio Informatics," Published by ADDison Wesley Longman Ltd., 1999
As students interact with the website and take assessments, the teacher is notified of the student's progress. Once the student submits his assessment, Molecular Workbench (2010) reports, "SAM activities end by generating a report that includes answers to multiple choice questions, annotated snapshots, and the text of open responses. These reports are emailed to the teacher. Students have a chance to edit reports before they are submitted." Use of this website could produce the next generation of scientists.
Technology used directly in the classroom to allow students and teachers to interact with each other includes the Audience Response System. According to Turningtechnologies.com (2010) the function of the system is declared, "TurningPoint audience response system integrates 100% into Microsoft® PowerPoint® and allows audiences and students to participate in presentations or lectures by submitting responses to interactive questions using a ResponseCard ™ keypad or other hand-held/computer devices." Made up of three basic…
Audio Response System. (2010). Retrieved on April 16 from http://www.turningtechnologies.com
DIIGO. (2010). Retrieved on April 16 from http://www.diigo.com/learn_more
Klopfer, E.; Osterwell, S.; Groff, J.; and Haas, J. (2009). "The Instructional Power of digital games, social networking, simulations and How Teachers Can Leverage Them."
Retrieved on April 12, 2010 from http://education.mit.edu/papers/GamesSimsSocNets_EdArcade.pdf
This information is utilized to create new products and substances that are used on a regular basis. For example, chemists could use the COSY process to understand how to create a new kind of raincoat that will be even more water resistant. To determine this, the protons inside the molecules of the raincoat would have to be examined through the COSY process. This will identify the peaks inside the protons and what specific attributes are similar to other compounds. Once this happens, is when scientists can use this as a way to create specific attributes that they are looking for (i.e. A raincoat that is more waterproof). This is significant, because it is showing how the contribution of the COSY methodology allows chemists to create new compounds with specific attributes. ("Thomaston," 2006)
HETCO is useful in understanding the genetic composition of a substance and the compounds that are used to…
Introduction to NRM Spectroscopy. (2003). UWI. Retrieved from: http://wwwchem.uwimona.edu.jm/spectra/nmrintro.html
Nuclear Magnetic Resonance. (2010). MSU. Retrieved from: http://www2.chemistry.msu.edu/faculty/reusch/VirtTxtJml/Spectrpy/nmr/nmr1.htm
Two Dimensional NMR. (2005). BBK. Retrieved from: http://www.cryst.bbk.ac.uk/PPS2/projects/schirra/html/2dnmr.htm
Bachovchin, W. (2001). Contributions of NRM Spectroscopy. Magnetic Resonance in Chemistry, 39, (1), 199 -- 213.
Alopecia areata is a systemic hair loss disorder, which affects roughly around 4.7 million people in the United States alone. [NAAF]. It is characterized as an autoimmune disease that leads to either localized or complete hair loss. The disease is independent of race, gender or age specifications, and hence affected people represent a diverse group. The effects of the disease may either be permanent or reversible depending on the nature and extent of damage to the hair follicles. It is believed that both genetic as well as environmental factors have an influence in the onset of the condition. However, the pathology of the disease is yet to be ascertained concretely. Though there is no physical distress accompanying the disease the psychological devastation suffered by the affected person is debilitating. Let us have a brief overview of the different types of alopecia before we discuss in detail the possible pathophysiology and…
1) NAAF, "What is Alopecia Areata," Accessed on March 8th 2005,
2) Ralph Paus, M.D and George Cotsarelis, M.D, "The Biology of Hair Follicles," NEJM, Vol 341, No 7, Pg 491.
3) Kyle Kennedy, M.D, "Management of Alopecia," Accesses on March 9th 2005,
Collision Model: Explanation and Application
The Collision Model is the theory that chemical reactions are the result of collisions between molecules. These molecular collisions must be strong enough to break bonds in the reacting substances. Breaking the bonds result in a rearrangement of the original configuration of atoms and a new product or products is formed ("Collision Model," Answer Corporation, 2006). Not every collision between molecules will create new products. In fact, the vast majority of collisions do not because they are not strong enough to break the existing bonds, which are often quite strong between molecules. For the collision to be successful, the molecules have to be oriented in such a way that the activation energy is sufficient to generate a reaction in the substance in question. Temperature, the presence of catalysts, the concentration of the substance, and other factors affect activation energy. Also, the molecules within molecular bonds…
Akeson, Wayne H. "Application of the Arrhenius Equation to rat tail tendon collagen."
Nature. 199, 185-186. 13 July 1963. 1 Oct 2008. http://www.nature.com/nature/journal/v199/n4889/abs/199185a0.html
The Arrhenius Equation." IUPAC Compendium of Chemical Terminology. 2nd Edition. 1997.
Oct 2008. http://www.iupac.org/goldbook/A00446.pdf
Transcription is a process that genetic information on the DNA copies into NA and the DNA acts as the template for the new molecules of NA. Transcription process begins with the DNA double helix unwinding as the hydrogen bonds holding the opposing bases breaks and the DNA strands are uncoupled. The process occurs within the cytoplasm of a prokaryote and in the nucleus of eukaryotic cells. Transcription process consists of three steps; initiation, elongation, termination, and are regulated by transcription factors that include protein products of the genes. The protein products regulate at postranscriptional levels every time.
Initiation of transcription begins with enzyme NA polymerase that identifies and attaches to DNA at the promoter and transcription of the DNA template starts. An initiation complex forms by association of 50 proteins different from each other required by NA polymerase II. NA polymerase synthesizes polynucleotides of NA from the template of DNA.…
Latchman, D. (2009). Eukoryotic Transcription Process. New York: Cengage Learning.
Alvis, F. (2010). New Approach to Translation Process. Chicago: Chicago University Press.
Singer, M. (2011). Genes and Genomes. New York: Cengage Learning.
Campbell, M. (2009). Biochemistry. London: Oxford University Press.
James Dewey atson
The Discovery of DNA was one of the most important discoveries in the history of Humanity, and it was accomplished by James atson and Francis Crick. Their discovery of the structure of DNA allowed scientists to begin to understand the mechanism behind inheritance. hile many scientists over the years had studied heredity, beginning with Gregor Mendel, no one had been able to discover the exact mechanism for how heredity actually works. It was not until the technology of the time advance to a point where scientists could determine the structure of molecules that the discovery of the structure of genetic material could be determined. After much research, and some failures, two scientists, working together, finally determined the molecular structure of the genetic molecule, allowing for the study of the exact mechanism to begin. James atson was one of the scientists responsible for the discovery of the DNA…
"Biography James Watson." Nobelprize.org. Nobel Prize Organization. 1964. Web. 14 April 2011.
"James D. Watson, Chancellor Emeritus" Cold Spring Harbor Laboratory. Cold Spring Harbor Laboratory. Web. 15 April 2011.
The chemical was found to turn on quorum sensing in V. fischeri, whereas it inhibited pathogen Pseudomonas aeruginosa. Also, the slow-release was shown to be far more effective than by applying the chemical directly as an aqueous solution. Since quorum sensing is also important for pathogen establishment this application could be important for inhibiting pathogenic bacteria from colonization of internal medical devices.
In summary, the V. fischeri and squid symbiotic relationship is an important model host-bacteria system. Aspects of colonization of host-symbiont and host-pathogen have been shown, using the V. fisheri and squid model, to be the same. Therefore, understanding the mechanism and complex transcriptional regulatory systems of V. fischeri could lead to potential new therapies and pharmaceutical applications. Likewise, understanding the environmental factors necessary for successful host-bacteria interactions could lead to novel drug targets. In addition to being important in understanding other harmful host-bacteria relationships the V. fischeri and…
Breitbach, a.S., Broderick, a.H., Jewell, C.M., Gunasekaran, S., Lin, Q., Lynn, D.M., & Blackwell, H.E. 2010. Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: Gradual release enhances activity. Chem Comm.
Chun, C.K, Troll, J.V., Koroleva, I., Brown, B., Manzella, L., Snir, E., Almabraz, H, Scheetz, T.E., Bonaldo, M.F., Casavant, T.L., Soares, M.B., Ruby, E.G., & McFall-Ngai, M.J. 2008. Effects of colonization, luminescence, and autoinducer on host transcription during development of the squid-vibrio association. PNAS 105(32): 11323-11328.
Lyell, N.L., Dunn, a.K., Bose, J.L., Stabb, E.V. 2010. Bright mutants of Vibrio fischeri ES114 reveal conditions and regulators that control bioluminescence and expression of the lux Operon. J. Bacteriol. 192(19): 5103-5114.
Murray, P.R., Rosenthal, K.S., Kobayashi, G.S., Pfaller, M.A. 1998. Vibrio, Aeromonas, and Plesiomonas. In M. Brown (Ed.), Medical Microbiology Third Edition (pp. 245-250). St. Louis, MO: Mosby.
Chemical Formula: C12H18Br6
Molecular eight: 641.70
3D Rendering using Chemitorium:
Functional Groups: bromo, cyclo
Shape and Geometric Features: The atom is always a 12-sided figure with six Br vertices. It takes the shape of an octagon that is connected to a hexagon on one side. In a three-dimensional rendering, the molecule takes on a more oval shape rather than the stricter appearance of the two-dimensional rendering.
Chiral Properties and Isomers:
Isomers are the addition or subtraction of electrons in the molecule. The below are the most common isomers of Hexabromocyclododecane. These are coded as alphahexabromocyclododecane, betabromocyclododecane, and gammabromocyclododecane. These indicate which portion of the Bromine in the molecule has been affected by the electron changes.
Chiral Diastereomers: -, ?-, and ?- HBCD
Chirality, by definition is a type of molecule that lacks an internal plane of symmetry. The chirality of Hexabromocyclododecane yields many pollutants which have an adverse…
Arnot, John. "An Evaluation of Hexabromocyclododecane (HBCD) for Persistent Organic
Pollutant (POP) Properties and the Potential for Adverse Effects in the Environment." European Brominated Flame Retardant Industry Panel (EBFRIP). 2009. Print.
"Chemical Book: Hexabromocyclododecane." Web. Apr. 30, 2011.
However, the use of this technology has also introduced a whole host of ethical and health issues. This is important, because how these issue are wrestled with in the future, will determine the way this technology will be applied to daily life.
A bibliography that includes all references cited in the report and a 1-2 sentence summary of what information was gained from each reference.
20 Questions on Genetically Modified Foods. (2010). HO. Retrieved from: http://www.who.int/foodsafety/publications/biotech/20questions/en/
This source identified specific ethical and health issues that are affecting the use of genetic engineering. It was useful in recognizing specific factors and issues that could be affecting the way genetic engineering is impacting daily life.
The Search for the Structure of DNA. (2010). Online Ethics. Retrieved from: http://www.onlineethics.org/Education/precollege/scienceclass/sectone/cs4.aspx
This source was useful in providing background as to when DNA was discovered and what compounds were looked at before its discovery.
20 Questions on Genetically Modified Foods. (2010). WHO. Retrieved from: http://www.who.int/foodsafety/publications/biotech/20questions/en/
The Search for the Structure of DNA. (2010). Online Ethics. Retrieved from: http://www.onlineethics.org/Education/precollege/scienceclass/sectone/cs4.aspx
What is DNA. (2010). NIH. Retrieved from: http://ghr.nlm.nih.gov/handbook/basics/dna
Ejelonu, A. (2002). What is the Human Genome Project. Serendip. Retrieved from: http://serendip.brynmawr.edu/biology/b103/f01/web1/ejelonu.html
Antimicrobial Agents in Household Use: Triclosan
Describe how Triclosan works on a molecular level. Explain how Triclosan differs from soap and bleach in its antimicrobial activity.
Triclosan blocks the active site of the enoyl-acyl carrier protein reductase enzyme (EN), this is the vital enzyme in the synthesis of fatty acid in bacteria (Levy et a, 1999). Blocking this active site by triclosan leads to the inhibition of the enzyme thus preventing the synthesis of the fatty acid by the bacteria, a process needed for building cell membranes and reproduction. Given the fact that this EN enzyme exists in humans, triclosan has been considered to be relatively friendly to humans. Due to its strong nature of inhibition, powerful antibacterial action can be achieved using only a small amount of triclosan.
Triclosan differs from soap and bleach in the mechanism of action. Levy et al. (1999) also clarify that whereas triclosan interferes…
Bester, K. (2003) "Triclosan in a sewage treatment process balances and monitoring data," Water
Research, 37(16): 3891-3896.
Levy, C.W. et al. (1999). "Molecular Basis of Triclosan Activity," Nature, 398, 383-384.
Lindstrom, A. et al. (2002) "Occurrence and Environmental Behavior of the Bactericide
At the molecular level, the mutation in the normal ApoA1 is because of a single amino acid substitution at the position 173, cysteine amino acid substitutes or replaces the arginine amino acid. Because of the presence of an extra cysteine, a cysteine bridge is formed that causes great changes in the protein structure. ApoA1 protein does not have a cysteine dimer but cysteine dimer is formed on Apo1 Milano that causes the protein to exist as a homo or a hetro dimer with ApoAII (Futterman and Lemberg 246). It has been reported that he enhanced cholesterol removal efficiency is not because of the presence of extra cysteine. Based on the replacement of arginine by a cysteine residue, the charge of the protein is shifter towards cathode. Because of the mutation, it has been reported that the removal of cholesterol from the inner arterial walls is accelerated and much higher. The…
Futterman, G. Laurie., and Lemberg, Louis. "Apo A-I Milano." Am J. Crit Care 14 (2005): 244-247.
Nissen, E. Steven., Tsunoda, Taro., Tuzcu, Murat, E., Schoenhagen, Paul., Cooper, J. Christopher., Yasin, Muhammad., Eaton, M. Gregory., Lauer, A. Michael., Sheldon, W. Scott., Grines, L. Cindy., Halpern, Stephen., Crowe, Tim., and James Blankenship, C. James. "Effect of Recombinant ApoA-I Milano on Coronary Atherosclerosis in Patients with Acute Coronary Syndromes: A Randomized Controlled Trial." JAMA 290(2003): 2292-2300.
Actions Estrogen and Progesterone in Endometrium and Breast: Puberty, Pregnancy and Puerperium Including Molecular Actions and Functionally Important Tissue Level Effects
Estrogen and progesterone are essential to cyclical changes that occur during puberty, pregnancy and peurperium. Complex molecular activity influences tissue changes in multiple reproductive organs including the uterus, endometrium, ovaries, breasts and more (Kimbrell & McDonnell, 2003).During a woman's reproductive cycle the hypothalamus secretes gonadotropin-releasing hormone or luteinizing releasing hormone which stimulates the release of luteneizing hormone and follicle stimulating hormone (Merck, 2005). This in turns promotes maturation of female ovum and stimulates the body's release of the reproductive hormones estrogen and progesterone during a woman's cycle. Estrogen and progesterone contain carbon atoms and other polycyclic compounds that are created from cholesterol and circulate within the bloodstream via plasma proteins (Merck, 2005).
Unbound estrogen and progesterone compounds stimulate the reproductive system including the endometrium, uterus and breasts to mature…
"Hormones of the Reproductive System of Females." Available:
Kimbrell, E.A. & McDonnell, D.P. (2003). "Function and mode of action of nuclear receptors: Estrogen, progesterone and vitamin D" Pure Appl Chem, 75(11-12): 1671. Available: http://www.iupac.org/publications/pac/2003/pdf/7511x1671.pdf
Merck & Co., Inc. (2005). Reproductive Endocrinology. The Merck Manual, Sec. 18, Ch.
Genomics and Implications for the Future
The Human Genome Project has completed its monumental mapping of the genetic sequence in human DNA, and the field of genomics is taking advantage of these initiatives and innovations in technology to pursue scientific inquiries that could not have been imagined just a few years ago. More importantly, perhaps, new applications are being discovered based on the growing body of scientific evidence being developed by this emerging science. To determine what genomics is and how it is being used today and may be used in the future, this paper provides an overview of the biochemistry involved in the study of genomics, followed by an analysis of current and future trends in this field. A summary of the research will be provided in the conclusion.
Review and Discussion
Background and Overview.
Today, genetic-engineering techniques are increasingly being applied to a growing number of life forms,…
Dooley, Erin E. (2004). "Y. F. Leung's Functional Genomics." Environmental Health
Genome news. (2003, September). Body Bulletin 4(9):6.
Goodman, Alan H., Deborah Heath and M. Susan Lindee. (2003). Genetic Nature/Culture:
Von Hippel Lindau Disease
Von Hippel-Lindau Disease
Von Hippel-Lindau Disease
Von Hippel-Lindau Disease
The von Hippel-Lindau, also known by its synonyms, familial angiomatosis cerebeloretinal, hemangioblastomatosis or retinal and cerebellar angiofacomatosis, is the abnormal growth of retinal- cerebellar vessels, and is classified as a rare disease of autosomal dominant hereditary character, within the group of phacomatosis. The disease was described by two independent groups, led by Eugen von Hippel (1904) and Arvid Lindau (1927). The cause of the disease is the mutation of both alleles of the VHL group, the one caused by genetic factors, and the second after a de novo mutation. The von Hippel-Lindau syndrome is considered by increased tendency to kidney tumors, central nervous system, including the cerebellum, and by affecting the retina. At the moment, no medical treatment is present for curing this disease, but knowledge of their symptoms and possible genetic research currently makes…
He's FJ, Hoppener JW, Lips CJ (2003). Clinical review 155: pheochromocytoma in Von Hippel-Lindau disease. J Clin Endocrinol Metab; 88: 969 -- 974.
Johnston LB, Chew SL, Trainer PJ, Reznek R, Grossman AB, Besser GM, Monson JP, Savage MO (2000). Screening children at risk of developing inherited endocrine neoplasia syndromes. Clin Endocrinol (Oxf); 52: 127 -- 136.
Lindau A (1927). On the question of angiomatosis retinae and your brain complicatio. Acta Ophthalmol; 4: 193 -- 226.
Lonser R, Glenn G, Walther M, Chew EY, Libutti SK, Linehan WM, et al. (2003). Von Hippel-Lindau disease. Lancet;361:2059-67.
Pathologists are often called 'the doctor's doctor ' -- when other doctors are experiencing an impasse, they go to a pathologist for advice, to provide clarity. As someone who has always enjoyed working as a teacher and preparing teaching materials, I look forward to this role in relation to my fellow physicians.
pon arriving in the nited States to practice medicine, I gained experience in the field of pathology-related research, collecting data about survival rates of patients with colorectal cancer and inflammatory bowel disease. I came to learn how pathology touches all fields of medicine. Even in my work with patients suffering substance abuse and psychiatric problems, I saw how the progression of the addiction created a pathology in terms of the way that the body responded to the patient's negative behaviors. I hope that this residency program will expose me to the laboratory and clinical aspects of the field,…
Upon arriving in the United States to practice medicine, I gained experience in the field of pathology-related research, collecting data about survival rates of patients with colorectal cancer and inflammatory bowel disease. I came to learn how pathology touches all fields of medicine. Even in my work with patients suffering substance abuse and psychiatric problems, I saw how the progression of the addiction created a pathology in terms of the way that the body responded to the patient's negative behaviors. I hope that this residency program will expose me to the laboratory and clinical aspects of the field, and give me the ability to learn from -- and perhaps to teach -- others who are grappling with issues spanning from cancer to nephrology to infertility to lifestyle-related illnesses.
From birth to death, I have seen the many varied states the human body can take in health and illness. My desire to engage in a pathology rotation is based upon these past, formative experiences and my desire to place this diversity within the uniquely helpful paradigms particular the discipline. By the end of the residency I know I shall not have realized my goal of becoming a 'doctor's doctor' but I am eager to enter upon the path and begin this lifelong journey.
J. Carlos Manivel, "Choosing pathology as a specialty," the University of Minnesota, May 2, 2010, [August 21, 2010] http://residency.pathology.umn.edu/
Initially he busied himself with performing and publishing new research findings. Through this endeavor he expanded his knowledge of chemistry and physics. When he moved from Pennsylvania to California in 1974, he began to serve as a mentor to graduate students. While mentoring others, he himself began learning a lot more about his field of study from his academic peers.
Soon afterwards Dr. Zewail felt encouraged to apply to certain top positions at several American universities. It was during this time that he received the offer to serve as a director at CalTech. At his new position Dr. Zewail enthusiastically worked beside scientists from diverse social and cultural backgrounds. Besides serving in a leadership position to the hundreds of students and faculty members under him, Dr. Zewail not only inspired others to perform at their very best but was also himself inspired to learn and understand new advances in physics…
A 1400-year-old volcanic or other induced "winter" likely spurred the divergence possibly even later than 150,000 years ago, brought about by an explosion of Toba in Sumatra. The elimination of this bottleneck 10, 000 years later allowed another wave of emigration from Africa. Volcanic winter may have succeeded in the reductions of populations to levels low enough for founder effects, genetic drift and local adaptations to produce rapid population differentiation (Ambrose 623 -- 651) .
This new research posits new assumptions about evolutionary rates, anagenesis, gene flow and population stability. Most biological evolution consists of the following two processes: anagenesis and cladogenesis. Anagenesis describes the transformations that occur within a single lineage, that is, as a population develops new characteristics. Cladogenesis, describes the splitting of a single species into two or more groups that later subsequently diverge in their individual traits through the anagenetic process. Gene flow and population stability…
Ambrose, Stephen H. "Late Pleistocene human population bottlenecks, volcanic winter, and differentiation of modern humans." Journal of Human Evolution. 34. (1998): 623 -- 651. Print.
Johanson, Donald. "Origins of Modern Humans: Multiregional or Out of Africa?" Action
Bioscience.org. 2011. Web. 6 May 2011.
At times, marvel how far have come. Ever since was a young boy, under the influence of my father, a molecular biologist, dreamed of researching genetically inherited diseases. Today, live that reality in my current field of work and research as a graduate student in neuroscience.
Thus, long before most children, because of my early exposure to the field of biology, was intimately aware that one's genetic inheritance could determine an individual's future physical and emotional health. Perhaps it comes as no surprise that soon decided was genetically coded to become a medical researcher. will receive my Ph D. n the summer of 2006 in neuroscience. But my current studies in the field of genetics have also soberly reminded me of how far both my own learning and the field of genetics need to be stretched, before the objectives of genetic research into inherited diseases can be realized.…
I have concluded that the hands-on clinical experience only provided by a medical school education is necessary for me to fulfill the essential experiential element that is crucial to my future desired knowledge base and scope of research. Only medical school will provide me with critical experience that will give my research the desired added practical and human value.
At the end of my education, I hope to become a research doctor who combines clinical research in his study of genetic diseases. I seek to provide the science of genetics with a human face for it is, ultimately, the study of the human body, mind, and 'wiring' in the form of the human genetic code. I been the recipient of a 'Sensory Neuroscience Training Grant '(SNTG) fellowship funded by National institute of health (NIH) since the fall of 2004. Thus I am well aware of the critical role genetics plays in public health of the nation as well as of the field of medical science, because of this generous grant, and I will strive to add to this knowledge in all of my future research.
Also, as a T.A. over the past two years, I have gleaned further knowledge of the curiosity of students for 'in the field' research. I have been grateful to have this human element present even in my PhD education. I am also proud to say I have not merely have received excellent reviews from my students, but joined them in many intramural soccer games, one of my favorite pursuits of my college years. I was not given the genetic gift, sadly, of becoming a great sports star, but I do believe that it is encoded in my own personal biology to bring a vital element of clinical humanity to the important work being done in the field of genetic research.
If there is disulfiram in the patient's system, it takes about 5-10 minutes for the effects of the drug to form the outward symptoms of a severe hangover. These symptoms last from 30 minutes to several hours, and may include flushing, rapid heart rate, shortness of breath, nausea, vomiting, throbbing headaches, mental confusion and even circulatory collapse. There is no known tolerance to the drug, the longer it is taken, the stronger the effects. Because of its molecular make up, it is absorbed slowly through the digestive tract with the effects lasting up to two weeks after the initial doses. This makes the issue of informed consent very important for this substance (Wright and Moore).
The efficacy of the drug is debatable. On one hand, the biological and chemical effects of are proven. One study showed that there is about a 50% compliance rate in a supervised atmosphere,…
Chemical Summary for Acetaldehyde. Office of Pollution Prevention and Toxics -- U.S. Environmental Protection Agency. 1994. Web.
Disulfiram. Drugs.com. Drug Information Online. 2011, Web.
Nakamura, K., et.al. Acetaldehyde Adducts in the Brain of Alcoholics. Archives of Toxicology. 77 (10): 591-3. 2004. Print.
Perry, L. Biology of a Hangover: Acetaldehyde. How Stuff Works. 2011. Web.
Doctor Determine Treatment for a Diagnosis of Hereditary Fructose Intolerance:
Explain how enzymes are involved in processes such as the breakdown of fructose.
The enzymes work as a lock and key process where the relevetn active part of the enzyme fits into the substrate (i.e. The molecule on which the enzyme acts) and activates it. There are various active sites on the enzyme and only the enzyme that will 'fit' in the substrate will work. After part of enzyme matching with substrate, enzyme breaks down substrate into two smaller products.
The following image illustrates:
(adapted from http://waynesword.palomar.edu/molecu1.htm)
At times the process can be blocked by an impediment that stops the 'key' from 'turning, as happens in the case of a lack in aldolase B. which can prompt hereditary fructose intolerance
Explain how a deficiency in aldolase B. can be responsible for hereditary fructose intolerance.
Hereditary fructose intolerance is a disease…
Berg JM, Tymoczko JL, Stryer L. (2002) Biochemistry. 5th edition. New York: WH Freeman
Cross NC, de Franchis R, Sebastio G, et al. (1990). Molecular analysis of aldolase B. genes in hereditary fructose intolerance. Lancet 335 (8685): 306 -- 9
Huntington's Disease Outreach Project for Education at Stanford Coenzyme Q10: An Antioxidant Drug
water in your area? ("Your perspective on water differs whether you live near the Great Lakes, in the arid west, or by the coast."(McCarthy, 2009)
Outline a brief water conservation plan for your own daily use. How will these changes affect your personal life? What impact will it have on your local water supply?
There is plentiful water in my region (I live in the Great Lakes region). Nonetheless, a brief water conservation plan is the following:
To use water for just its needs and to ensure that tap water is not left running in between those needs.
To double used bathwater as water that can be used for washing the floor.
To, as much as possible, use rainwater for gardening
In order to supply water to humans certain technologies must be utilized.
Desalination is one of the methods that are used for promoting pure water supply. It literally means…
FAO report reveals GM crops not needed to feed the world http://www.psrast.org/faonowohu.htm
Forbes.com (11/03/2012) GMO Food Debate in the National Spotlight http://www.forbes.com/sites/rachelhennessey/2012/11/03/gmo-food-debate-in-the-national-spotlight/ )
Greenopolis. Top 10 Environmental Success Stories and 10 Future Challenges. http://greenopolis.com/goblog/joe-laur/top-10-environmental-success-stories-and-10-future-challenges
Groves, J (19 December 2009 ) Climate change summit accepts 'toothless' U.S.-backed agreement - but deal is not legally binding DailMail.com http://www.dailymail.co.uk/news/article-1236659/Copenhagen-climate-change-conference-World-leaders-reach-Copenhagen-agreement -- officials-admit-enough.html#ixzz2Cg3714zQ
Diffusion and Osmosis Experiment Lab eport
The core purpose of the first experiment conducted in the lab was to study the principle of diffusion. The experiment aimed at analyzing the movement of molecules from a region of higher concentration towards lower concentration. Potassium permanganate crystals were dissolved in water to observe the process of diffusion. The observations and results attained from the experiment indicated the movement of molecules which occurred due to molecular collisions, taking place more frequently in areas of higher concentration.
Molecules present in a liquid or a gas move about constantly in random directions. During their movement, they bump into each other and bounce this way and that way. This random movement ultimately results in the uniform or even distribution of molecules. The tendency of molecules to spread out evenly throughout the space occupied by them is referred as diffusion. The process of diffusion does not require…
Jeff, Sack. Osmosis and Diffusion, American Biology Teacher, 67.5 (2005), pp. 3-11, Retrieved
October 19, 2012, from http://www.eric.ed.gov/ERICWebPortal/search/detailmini.jsp?_nfpb=true&_&ERICExtSearch_SearchValue_0=EJ725843&ERICExtSearch_SearchType_0=no&accno=EJ725843
Lauren, M., Victor, S. & Lindsay, M. Exploring Osmosis and Diffusion in Cells: A
Guided-Inquiry Activity for Biology Classes, Developed through the Lesson-study Process. Science Teacher, 77.8(2010), pp. 55-60, Retrieved October 19, 2012, from http://www.eric.ed.gov/ERICWebPortal/search/detailmini.jsp?_nfpb=true&_&ERICExtSearch_SearchValue_0=EJ912491&ERICExtSearch_SearchType_0=no&accno=EJ912491#
Nuclear magnetic resonance (NM) spectroscopy is one of the most powerful and versatile techniques available to determine the arrangement of atoms in the structure of a molecule. Organic molecules composed principally of hydrogen and carbon atoms can be analyzed using techniques of proton (1H) and carbon-13 (13C) NM spectroscopy. The basic interpretation of the NM spectra for a molecule observes several properties including the strength and intensity of the magnetic field used to produce a peak, the interaction of the atom with atoms around it and the effects of neighboring atoms on spectra themselves. Analysis of the relative location of a peak in an NM spectrum (called the chemical shift) and the splitting of that peak can provide significant information about the structure of a molecule. More detailed information about molecular structure can be determined through 2-dimensional techniques where the NM pulses producing a magnetic field are combined…
Carey, F.A., & Giuliano, R.M. (2008). Organic Chemistry. New York: McGraw Hill.
Pauli, W. (1940) . The connection between spin and statistics. Physical Review B. 15, 716-730.
Roberts, R.M.; Glibert, J.C.; Rodewald, L.B.; Wingrove, A.S.(1982) Modern Experimental Organic Chemistry (pp. 239). New York, NY: CBS College Publishing.
Silverstein, R.M.; Bassler, G.C.; Morrill, T.C. (1974) Spectrometric Identification of Organic Compounds, 3rd Ed. (p. 24). New York, NY: Wiley.
life I have been a go-getter. I graduated from high school at 16 because I was eager to begin my college education. Currently I am working on dual Bachelor degrees. One will be in Biochemistry and the other will be in Psychology. The same personality trait that has allowed me to graduate from high school early, pursue a dual degree program and many other accomplishments, is what will turn me into a service orientated and dedicated dentist.
One of the things I have pursued as a University of California, San Diego student, is my membership in the campus "For Los Angelitos" club. One of the things we did as a club was to travel to poverty stricken areas and provide lessons about oral hygiene. Equipped with small bags filled with oral care products, we traveled to Tijuana, Mexico where we provided oral care education to the children of the area.…
Merkel Cell Carcinoma
Griffiths, D., et al. (2013). Merkel Cell Polyomavirus Small T. Antigen Targets
the EMO Adaptor Protein To Disrupt Inflammatory Signaling. Journal of Virology. 87 (24), 13853-67.
Merkel cell carcinoma is a relatively rare disease in which malignant cells form in the skin, usually in individuals who have a weak immune system or extensive exposure to the sun. Merkel cells are found in the top (epidermis) layer of the skin, close to the nerve endings that house responders to touch. Merkel cell carcinoma is also known as neuroendocrine carcinoma of the skin, sometimes as trabecular cancer. It forms when the Merkel cells grow rapidly and out of control, usually starting in areas of the skin that have more exposure to the sun (neck, arms, legs, etc.). The cancer tends to grow robustly and metastasize at a relatively early stage. Typically, it spreads to nearby lymph nodes and then…
" (Sukumaran, 2004) Mutation is what results in the difference and may be utilized as a measure of the time that has elapsed since separation of the species from the common ancestor during evolution. This is a method of "inferring the divergence of time of clades from a common ancestor by means of gene/protein sequencing" and has been termed 'molecular dating'. The process is one in which there is a calibration of time in comparison to the Phanerozoic era fossil data and then expoliation is conducted for providing the estimation time for divergence of phyla. (Sukumaran, 2004; paraphrased) Indeed, if life did evolve as posited in the work of Charles Darwin then "the abrupt appearance of diversified life at the beginning of the Cambrian period was not explainable." (Sukumaran, 2004) However, Sukumaran explains that gradualism is not a central tenet to the idea that there has been an evolution of…
Fenchel, Tom (2002) the Origin and Early Evolution of Life. Oxford University Press 2002.
Wray et al., Molecular evidence for deep Precambrian divergence among metazoan phyla, Science, Vol. 274, pp. 568-573, 1996
Gon, S.M. III (2005) Trilobites of Chengjiang, China. 27 Apr 2005. Online available at http://www.trilobites.info/Chengjiang.htm
Gon, S.M. III (2007) Trilobites of the Emu Bay Shale, Australia 7 July 2007. Online available at http://www.trilobites.info/Emu.htm .
Amidation of Peptides in Humans
Modern biotechnology has experienced dramatic leaps in the body of knowledge concerning molecular processes in peptides and how they work. Many of these processes rely on amidation of peptides to achieve increasingly important medical and commercial applications. Peptides are created when two or more amino acids are covalently joined by peptide bonds, a process termed post-translational modification. One increasingly valuable application of post-translational modification is amidation. This paper provides an overview of peptides and their role in biological processes, how amidation of peptides works and its importance, and a description of the two functional domains of the PAM enzyme (PHM and PAL) and the roles they play in amidation. An assessment of whether amidation prevents C-terminal degradation is followed by a discussion of which peptides/proteins are susceptible to C-terminal degredation by carboxypeptidase. An analysis of whether E. coli can be modified to perform amidation will…
Allen, J.M. (1963). The nature of biological diversity. New York: McGraw-Hill.
Audesirk, T. & Audesirk, G. (1993). Biology: Life on Earth, 4th ed. Upper Saddle River, NJ: Prentice Hall.
Bradbury, A.F. & Smyth, D.G. (1988). Biosynthesis of peptide neurotransmitters: studies on the formation of peptide amides. Physiol Bohemoslov, 37(3), 267-74.
Brighton, P.J., Szekeres, P.G. & Willars, G.B. (2004). Neuromedin U. And Its Receptors: Structure, Function, and Physiological Roles. Pharmacological Review, 56, 231-248.
This teatment, albeit, does not poduce 100% chitosan, but basically poduces a mixtue of 10-15% chitin plus 85-90% pue chitosan, called "pue CC." In the U.S., chitosan constitutes a mixtue of appoximately7% chitin plus appoximately 93% chitosan. Outside of cost-effectiveness, the biological effects of chitin poduced fom each souce appeas identical. "Chitosan oligosacchaides (CO) takes chitosan a big step futhe," Matsunaga (2007 explains. "When CC is ingested, a small amount of it is boken down into vey small molecula paticles by the enzymes of the body, thus poducing CO. CO can also be manufactued by using an enzymatic pocess" (Matsunaga, as cited in Levine, p. 1). The body moe eadily absobs CO, although CO contains less fibe than egula CC.
In Case Histoy 1: Low Pulmonay (Lung) Function, Matsunaga (Levine, 2007) teats his fist patient, also his fathe, with the administation of CC. Pevious teatments had yielded no esults…
references and further reading you must purchase this article.
Lee, H., Park, Y., Jung, J. & Shin, W. (2003). Chitosan oligosaccharides, dp 2 -- 8, have prebiotic effect on the Bifidobacterium bifidium and Lactobacillus sp.
Elsevier Science Ltd. Retrieved November 2, 2009, from http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6W9T-48BKR97 -
Chemical Compound: Sucrose
Sugar (Sucrose) -- C12H22O11
The compound chosen for discussion in the paper is- sucrose. The reason behind choosing this compound is that it is a substance of everyday use, consumed worldwide. Its commonness has led people to consider sucrose as an ingredient whose solitary purpose is what it is commonly used for- as sugar- and not in the form of a chemical compound. Therefore, sucrose is chosen for study out of curiosity regarding it.
This paper will look into a chemical and physical description of sucrose, its economic significance, its relation to prior class studies, as well as its change of state. Employing various concepts like 'international system of measurements (SI)' units, the properties of the compound will be elucidated.
Pure sucrose, often, takes the form of an odorless, colorless, fine crystalline powder having a sweet, pleasant taste. It can be prepared in…
Blauch, D.N. (2001). Le Chatelier's Principle: Effect of a Change in Temperature. Retrieved july 22, 2015, from http://www.chm.davidson.edu/vce/equilibria/temperature.html
Cameo Chemicals. (n.d.). Sucrose. Retrieved July 22, 2015, from http://cameochemicals.noaa.gov/chemical/12695
edinformatics. (n.d.). Sucrose. Retrieved July 22, 2015, from http://www.edinformatics.com/math_science/science_of_cooking/sucrose.htm
Fairtrade Foundation. (2013). Fairtrade and Sugar. Fairtrade Foundation.
Huntington's disease (HD) was the first autonomic dominant disorder for which genetic prediction became possible" (Harper, et al., 2000, Journal of Medical Genetics, p. 567). HD is a disease that occurs due to an inherited disorder leading to the death of brain cells. A diagnosis of HD is accomplished through genetic testing which can be implemented at any age regardless of whether the symptoms manifest or not. Although, the specific symptoms vary between people, nevertheless, symptoms can start with people between 35 and 45 years of age and can also start in some individuals at even anearlier age. The disease may affect successive generations if health interventions are not implemented (Mandel, 2016).
Additionally, "the cause of HD is due to a dominant mutation of autosomal form of the gene called Huntington. This shows that a child born by an affected person has a 50% chance of developing or inheriting the…
Causes and risk factors. (2016). Health Communities. Retrieved from http://www. healthcommunities.com/huntingtons-disease/cause.shtml.
Denbo, S. M. (2013, January 1). Balancing the rights of children, parents and the state: The legal, ethical and psychological implications of genetic testing in children. Southern Journal of Business and Ethics, 5, 188-190.
Domaradzki, J. (2015, January 1). Lay constructions of genetic risk. A case-study of the Polish Society of Huntington's Disease. Polish Sociological Review, 189, 107-111.
Draper, B. (2004). Dealing with dementia: A Guide to Alzheimer's Disease and other dementias. Crows Nest, NSW: Allen & Unwin.
Philosophy of Chemistry
The work of Scerri (2000) asks the question of what could the connections between chemistry and philosophy possible be "apart from the obvious superficial one of their both representing quests for knowledge?" (p.1) Scerri states that in the view of the chemist "the philosopher -- who conducts no experiments whatsoever -- is not worthy of very high esteem. From the scientific perspective, philosophical views do not seem very dynamic, since they sometime stem from established philosophical doctrines or a priori beliefs about the ways the world should be." (2000, p.1) It is reported as well that philosophers "for their part are proud of their training in rigorous ways of thinking. They freely admit to not engaging in the grubby details of the experimental world because such activities might limit the generalities of their claims and of their attempts to depict reality in its broadest terms." (Scerri, 2000,…
Scerri, ER (1997) Philosophy of Chemistry -- A New Interdisciplinary Field?. Retrieved from: http://www.chem.ucla.edu/dept/Faculty/scerri/pdf/poc_=JCE_article.pdf
Hoffmann, R. The Same and Not the Same; Columbia University Press: New York, 1995. Knight, D. Ideas in Chemistry, Rutgers University Press: New Brunswick, NJ, 1992. Nye, M.J. From Chemical Philosophy to Theoretical Chemistry; University of California Press: Berkeley, 1993. Laszlo, P. La Parole des Choses; Collection Savoir-Science: Paris, 1993. Hoffmann, R.; Laszlo, P. Angew. Chem., Int. Ed. Engl. 1991, 30, 1 -- 16
Scerri, ER and McIntyre, L (2000) The Case for the Philosophy of Chemistry. Retrieved from: http://philsci-archive.pitt.edu/256/1/Case_for_poc.pdf
Schummer, J. (2006) Philosophy of Chemistry. in: Donald M. Borchert (ed.), Encyclopedia of Philosophy, Second Edition, Macmillan, New York 2006. Retrieved from: http://www.joachimschummer.net/papers/2006_Philchem_MacmillanEncyclopedia.pdf
Using MRS chemical composition of the tumor and the metabolite intensities can also be ascertained along with the morphological characterisitcs. Thus MRI provides better information which is useful in grading the tumor. For grade 4 astrocytoma's spectroscopic studies reveal high Cho, high lipid, high lactate and low NAA values. However, the MRI testing is time consuming (40 to 90 minutes) and is problematic for claustrophobic patients. [eMedicine] iopsy of the affected brain tissue will also help in determining the nature of the abnormal tissue growth.
Treatment for astrocytoma includes, surgery, chemotherapy, radiation and gluco corticoid medication. Treatment improves the survival rates for patients and the type of treatment depends on the growth and location of the tumor. First grade tumors such as Pilocytic Astrocytomas are easily treated by resection. In most cases removal of the affected part would be sufficient. However, if the location of the tumor makes surgery…
Capodano AM. Nervous system: Astrocytic tumors. Atlas Genet Cytogenet Oncol Haematol. November 2000. Available at, http://AtlasGeneticsOncology.org/Tumors/AstrocytID5007.html
BTS, "Brain Tumor Facts & Statistics," Accessed Nov 18th 2007, available at http://www.tbts.org/itemDetail.asp?categoryID=384&itemID=16535
Karen T. Barker and Richard S. Houlston, "Overgrowth syndromes: Is dysfunctional P. 13 Kinase signalling a Unifying mechanism," European Journal of Human Genetics (2003) 11, 665-670. Available online at, http://www.nature.com/ejhg/journal/v11/n9/full/5201026a.html
Medscape, " a Review of Astrocytoma Models: Molecular pathologies of Astrocytoma," Neurosurgical Focus 8(4), 2000 eMedicine, "Astrocytoma, Brain," Accessed on Noiv 18th 2007, available at http://www.emedicine.com/radio/topic60.htm
Ga DOA OC Radio Pharmaceutical
Neuroendocrine tumors (NE) are neoplasms characterized by tissue immunoreactivity for neuroendocrine differentiation markers, appearance as a small mass that can be off white to yellow often in submucosa and prevalence throughout the body but typically found in the intestine or lungs (Oberg2011). he tumors can be malignant and are typically detected through hormone markers in a first diagnosis (Arnold 2003). Because of the diffuse nature of this type of tumor, detecting and imaging NEs requires scanning and typically requires a contrast agent to detect the location of tumors in tissue (an 2011). Many NE cells possess an overexpression of somatostatin receptors on their surface (Kwekkeboom 2005, VenEssen 2007). Somatostatin receptors are cell surface proteins that bind to somatostatin, a growth hormone inhibiting hormone that regulates the endocrine system and affects neurotransmission and cell proliferation (Florio 2002). he overexpressed somatostatin receptors can be used to both…
Tan, E.H.; Tan, C. (2011). Imaging of gastroenteropancreatic neuroendocrine tumors, World Journal of Clinical Oncology 2 (1) 28.
VanEssen, M. Krenning, EP., DeJong, M., Valkema, R., Kwekkeboom, D.J. (2007) Peptide receptor radionucleotide therapy with radiolabelled somatostatin analogues in patients with somatostatin receptor positive tumors, Acta Oncology 46, 723-734
Veliklyan, I. Xu, H. Nair, M. Hall, H. Robust labeling and comparative preclinical characterization of DOTA-TOC and DOTA TATE. Nuclear Medicine Biology 18, 123-128.
History of Pediatric Hemolytic Monitoring
Retrospect to the career of physician, Dr. James A. olff I and his early progress in treatment of Rh hemolytic disease as described in Pochedly (1984), looks at the development of interest in hematology in European field hospitals during orld ar II. After the war period, the transformation of olff's research in this area was advanced by research conducted during a pediatric residency at the Boston Children's Hospital, between 1945 and 1947. During his tenure at Children's he was engaged with Dr. Louis Diamond in his seminal investigation on treatment of erythroblastosis fetalis by exchange transfusion.
Collaborative efforts with Drs. Diamond and Farber focused on preliminary clinical trials of aminopterin for the treatment of acute leukemia, of which olff was in observation. Instrumental to the development of the concept of treating erythroblastosis fetalis by exchange transfusion; collaborative in the area of pathophysiology of disease where…
Al-Eisa, A. And Al-Hajeri, M. Hemolytic uremic syndrome in Kuwaiti Arab children. Pediatric Nephrology 16.12 (2001): 1093-1098.
Blouin, P. et al. Syndrome d'Evans: etude retrospective de la societe d'hematologie et d'immunologie pediatrique (36 cas). Archives De Pediatrie: Organe Officiel De La Societe Francaise De Pediatrie 12.11 (2005): 1600-1607.
Feldman, S.D. And Tauber, A.I. Sickle Cell Anemia: Reexamining the First "Molecular Disease." Bulletin of the History of Medicine 71.4 (1997) 623-650
Friedmann, A.M. et al. Fatal autoimmune hemolytic anemia in a child due to warm-reactive immunoglobulin M. antibody. Journal Of Pediatric Hematology/Oncology: Official Journal Of The American Society Of Pediatric Hematology/Oncology 20.5 (1998): 502-505.
Linear sp Carbon Allotropes in Question
While modern day discoveries and characterizations of allotropes are reported, the definition of allotropy remains ambiguous as the question of what constitutes an allotrope is under debate. Lagow et al. reported the synthesis of a terminally capped linear acetylenic carbon with alternating single and triple binds, claiming it to be a stable sp carbon allotrope (1994), a subject of debate as the classification of acetylenic carbon as an allotrope continues to be determined, and the stability of such a compound is in question. The proposed structure and stability of a linear sp carbon of such a proposed length and with alternating single and triple bonds is disputed by Hirsch et al. Thus, the stability of long-chain carbon allotropes and the characterization of the linear sp carbon synthesized by Lagow et al., given its terminal end design, remains in question as to the…
Demishev, SV, Pronin, AA, Sluchanko, NE, Samarin, NA, Glushkov, VV, Lyapin, AG, Kondrin,
MV, Brazhkin, VV, Varfolomeeva, TD, Popova, SV, & H. Ohta. (2002). "New nanocluster carbyne-based material synthesized under high pressure." General Physics Institute, Russian Academy of Sciences. Russia: Moscow. Vol. 44, No. 4, pp. 585-588. [Online]. Available at http://www.ioffe.rssi.ru/journals/ftt/2002/04/p585-588.pdf
Lagow, RJ, Kampa, JJ, Wei, HC, Battle, SL, Genge, JW, Laude, DA, Harper, CJ, Bau, R,
Stevens, RC, Haw, JF, & E. Munson. (20 Jan. 1995) "Synthesis of Linear Acetylenic Carbon: The 'sp' Carbon Allotrope." Science, New Series. Vol. 267, No. 5196, pp. 362-367.
Desiccation Tolerance in Prokaryotes
Prokaryotes or eukaryote is the organism that makes up the microbial world. Prokaryotes are deficient of internal unit membranes and are self-sufficient cells or organisms. The best-known prokaryotic organisms are the bacteria. The cell membrane in prokaryotes makes up the cell's primary osmotic barrier and consists of a phsopholipids unit membrane. The ribosome carries out translation and protein synthesis and is present in the cytoplasm. Normally, the nuclear regions consist of circular, double-stranded deoxyribonucleic acid.
Plasmids, the accessory self-replicating genetic structure is present in many prokaryotes with extra not necessary cell functions like encoding proteins to inactivate antibiotics. On the other hand, the eukaryotic cells have a nuclear membrane, well-defined chromosomes, mitochondria, a sector device, an endoplasmic reticulum and digestive system with many cell types. The prokaryotes are deficient of structural multiplicity and consist of millions of genetically distinct unicellular organism, which is well-known among eukaryotes…
Desiccation tolerance of prokaryotes" Retrieved at http://www.cryonet.org
Engineering desiccation tolerance in Escherichia coli" Billi, Daniela; Wright, Deborah J; helm, Richard F. Pricket, Todd; Potts, Malcolm; Crowe. John H. Retrieved at http://www.nencki. gov. pl
Major groups of prokaryotes" Retrieved at http://www.bact.wisc.edu
Mechanisms of plant desiccation tolerance" Hoekstra, Folkert A; Golovina, Elena; Buitink, Julia. Retrieved at http://www.plantstress.com
, 2006). He visualized and described the malignancy process. He suggested that early that "cells of tumors with unlimited growth" would develop with the elimination of chromosomes, which inhibit the growth. The multiple genetic alterations in these inhibiting chromosomes are today known as TSGs. The theory supposes that cancer arises from functional defect or absence of one or more TSGs. Clinical trials of TSG gene replacement therapy for breast cancer include the viral wild-type p53, Rb, and mda7. Molecular chemotherapy involves the introduction of suicide genes. The concept evolved from the assumption that cancer cells could be made more sensitive to chemotherapeutics or toxins by introducing "suicide genes." It was a concept initiated in the late 80s. Suicide gene therapy is categorized into toxin gene therapy and enzyme-activating pro-drug therapy. Suicide gene therapy is also called gene-directed enzyme pro-drug therapy or GDEPT. GDEPT treatment consists of the delivery of the…
Abaan, O. D and Criss, Wayne E (2002). Gene therapy in human breast cancer. 32
(2002): 283-291 Turkey Journal of Medical Science: Tubitak. Retrieved on April 15,
2010 from http://journals.tubitak.gov.tr/medical/issues/sag-02-32-4-1-0204.pdf
Lowery, A.J., et al. (2009). MicroRNA signatures predict oestrogen receptor,
This became more so with the advancement of molecular iology Tests. Subsequently a group of clinicians met in Ghent elgium and came up with the current diagnostic criteria known as the Ghent Nosology. (De Paepe et al. 1996) Similar to the erlin Nosology the Ghent criteria was based on clinical findings in the various organ systems as well as the nature of family history and relationships, a major criteria was classified as which has a high diagnostic specificity because it was less frequent in other conditions and in the general population. A point of divergence from the erlin Nosology was the conversion of minor criteria in the skeletal system into major criteria. For one to be diagnosed with Marfan's the patient must have a first degree relative diagnosed with the disease in addition two systems must be involved with one having a major sign. In the absence of a family…
Beighton, P., de Paepe, a., Danks, D., Finidori, G., Gedde-Dahl, T., Goodman, R., Hall, J.G., Hollister, D.W., Horton, W., McKusick, V.A., Opitz, J.M., Pope, F.M., Pyeritz, R.E., Rimoin, D.L., Sillence, D., Spranger, J.W., Thompson, E., Tsipouras, P., Viljoen, D., Winship, I., Young, I (1988). International nosology of heritable disorders of connective tissue. Am. J. Med. Genet. 29: 581-594,
Borger F (1914): Uber zwei Falle von Arachnodaktylie. Zschr Kinderheilk 12: 161 -1-84.
Baer RW, Taussig HB, Oppenheimer EH (1943): Congenital aneurysmal dilatation of the aorta associated with arachnodactyly. Bull Johns Hopkins Hosp 72:309-33 1.
De Paepe, a., Devereux, R.B., Dietz, H.C., Hennekam, R.C.M., Pyeritz, R.E.( 1996) Revised diagnostic criteria for the Marfan syndrome. Am. J. Med. Genet. 62: 417-426
Pharmacokinetics explains the process by which a drug is absorbed, distributed, metabolized, and eliminated from the body. These processes are dependent on the amount of the drug administered, the method of administration (which affects the rate of absorption, biotransformation, and even excretion), and how the drug binds in the tissues. In essence, a drug's ability to transverse the cellular membranes depends on its solubility and molecular size and shape. The passive diffusion of the drug across cellular membranes depends on its lipid solubility as well as concentration gradients outside and inside the cellular membrane and the pH differences across the membrane. Active transport of the drug occurs when the drug is actually moved by components of the membrane. This can allow a drug move against concentration and electrochemical gradients but it requires energy, can be selective, and can be inhibited by similar molecules. The absorption rate is influenced…
Efforts to Achieve Healthy Aging
Institute of Chinese Medicine, The Chinese University of Hong Kong, HKSA.
Abstract: Longevity is a blessing as long as good health is not lost. However, the tendency to have a decline on normal physiological activities is inevitable because of the natural processes of degeneration at all levels: molecular, cellular and organic. Hence, the elderly people frequently suffer from cardiovascular problems and skeletal deteriorations that gradually develop to disabilities. Awareness of factors leading to unhealthy aging has led to the formation of different professional groups that aim at the maintenance of health of aging community. The approach tends to be target orientated for the European and US groups, aiming at hormonal replacements and detoxification. In contrast, the oriental groups have been keeping their traditional belief of prevention and internal balance, using nutritional arrangements and non-strenuous exercise as means of maintaining health.
Keywords: chinese medicine,…
Abreu, M.T., Fukata, M. and Arditi, M. 2005. T.L.R. Signalling in the gut
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Census and Statistics Department, The Government of Hong Kong Special
Administrative Region. 2007. Style Guide [online]. Accessed 23 June
2008. URL: http://www.censtatd.gov.hk/hongkongstatistics/
Advancement of nanotechnology has gained significant attention in the self -- assembling characteristic of a variety of molecules, which is a vital requirement for the growing bottom -- up design of nanoscale structures. hen these molecules go through molecular self -- congregation, the consequential structural elements, for instance nanotubes or vesicles, can be further transformed to give specific charactistics to the components. Like nanotubes can be covered with metals or partially -- conducting substances to fabricate nanowires.
Smart polymeric gels are classified on various structural properties. Superporous hydrogels (SPHs) are utilized to augment the responsiveness of hydrogels. In this case, the augmented responsiveness to stimuli is accomplished by manufacturing interconnected absorbent networks. Superporous hydrogels (SPHs) correspond to a rapid -- swelling group of hydrogels with pore dimensions much bigger than the usual network of a normal hydrogel. These were firstly created as modern gastric retention devices to augment the duration…
Annaka, Masahiko and Tanaka, Toyoichi, Multiple phases of polymer gels, Nature, ISSN 0028-0836, 2005, pp. 430-432
Darmawan, Adi; Smart, Simon; Julbe, Anne; Diniz da Costa, Joao Carlos, Iron Oxide Silica Derived from Sol-Gel Synthesis, Materials, ISSN, Volume 4, Issue 2, 2011, pp. 448-456
Heitfeld, Kevin a, Smart membranes: Hydroxypropyl cellulose for flavor delivery, ISBN 9780549027560, 2007, 15.
Hu, Jinlian, Adaptive and Functional Polymers, Textiles and Their Applications, ISBN 1848164750, 2011, p. 416
Stars are one of the important heavenly objects of our universe. The sun is our closest star and is responsible for the sustenance of all life on earth. Understanding the intricate chemical reactions that are happening in the star and identifying the composition of the stars has always been a fascinating study for astronomer's worldover. The sun our closest star has been the most studied object in the universe. Spectroscopy was one of the earliest available methods of studying heavenly bodies and has contributed immensely in the study and understanding of the composition of stars. Let us briefly analyze spectroscopy and touch upon the elemental analysis and chemical composition of stars.
Spectroscopy and Study of Stars
Every element in the universe emits its own light, which is characteristic of its chemical structure. Spectroscopy refers to the study of the spectral lines of the different atomic constituents. Spectrometer is an instrument,…
MARK S. GORDON, MICHAEL W. SCHMIDT, "RECENT ADVANCES IN QM AND QM/MM METHODS," Accessed on December 19th, 2003, http://www.msg.ameslab.gov/Advances/gamess_paper.march16.html
C.R Kitchin, "Optical Astronomical Spectroscopy," IOP publishing Ltd., 1995
I.S Glass, "Handbook of Infrared Astronomy," Cambridge University Press, 1999
Inheritable neuropathies are among the globe's healthcare challenges today. Although their incidence is not as high, one in every 2500 people, as compared to other major healthcare problems, their symptoms, and consequences are equally fatal. Charcot Marie Tooth disease is among the inherited neuropathies, which has significantly shown potential and fatal consequences to people. Notably, the disorder does not have any known cure, but there are numerous therapies to control the disease. Although this is the current case, advancements in medicine, are gradually bearing fruits because experts have discovered a way to diagnose some types of these deadly disorders. Other types of neuropathy disorders include hereditary neuropathy with liability to pressure palsy (HNNP), hereditary motor neuropathy (HMN), and hereditary sensory and autonomic neuropathy (HSAN or hereditary sensory neuropathy). In a second part of this paper is an experiment to detect HaeIII in given human DNA samples. Owing to…
Brown, W.M. (1980).Polymorphism in mitochondrial DNA of humans as revealed by restriction endonuclease analysis. Proc. Natl. Acad. Sci., 6, pp. 3605-3609.
Murphy, M.S. et al. (2012). CharcoteMarieeTooth disease: frequency of genetic subtypes and guidelines for genetic testing. J Neurol Neurosurg Psychiatry, 83, pp. 706-710
Orita, M et al. (1989). Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms. Proc. Natl. Acad. Sci., 86, pp. 2766-2770.
Saporta, S.D. A et al., (2011).Charcot Marie Tooth (CMT) Subtypes and Genetic Testing Strategies. Ann Neurol, 69(1), pp. 22 -- 33
Therapies Deprive Patients From Conventional Cancer Therapies
Future Ethical Prospective
Do public demand for, and clinicians' tendencies to prescribe novel targeted cancer therapies in a resource starved healthcare system deprive other patients of conventional treatment? If so, can it be justified?
Over the years, there have been several studies which have shown that a small but noteworthy fraction of cancer patients drop one or more conventional cancer treatments and use novel targeted cancer therapies instead. When it comes to recent public demands in healthcare, research into cancer control has addressed issues relevant to novel targeted cancer therapies in a resource starved healthcare system. Disparities have been addressed to a much greater degree than before, with studies of the conventional treatment of cancer especially in our variety of ethnic and socioeconomic settings. Conventional treatment have a greater social impact and the demand for such treatments of many (male and female) of…
Borja-Cacho, D.J.E.H.S.A.K.B.D.J. & V.S.M., 2008. Molecular targeted therapies for pancreatic cancer.. The American Journal of Surgery, 196(3), p. 430.
Garvalov, B.K. & A.T., 2011. Cancer stem cells: A new framework for the design of tumor therapies.. Journal of Molecular Medicine, 89(2), pp. 95-107..
Kim, J.A., 2003. Targeted therapies for the treatment of cancer. The American Journal of Surgery, 186(3), pp. 264-8.
Kundu, S.K. & N.M., 2012. Targeted therapy in head and neck cancer.. Tumor Biology, 33(3), pp. 707-21.
Candidate Genes for Schizophrenia
Their Impact on Neuro-development
Search Improvement over Published Methodology
rief Introduction -- Schizophrenia is a mental disorder, which is characterized by delusions, lack of drive and interest, changed or unusual emotional reactions and generally disorganized behavior (Kirov et al. 2012). Some signs may begin from childhood but main features become apparent in the late teens and early adulthood. Outcomes and treatment are varied but relapses are frequent. Remissions are also often only partial along with significantly reduced social and occupation involvement. Persons with this disorder are among the most vulnerable, ostracized, and thus disadvantaged in society. A recent meta-analysis reported that about 15.2 out of every 100,000 persons are afflicted with it (Kirov et al.).
Genetic epidemiological studies theorize that varied susceptibility to schizophrenia appears to be strongly genetic (Kirov et al. 2012). These studies have identified many potentials links between genes and chromosomal abnormalities. Increasing…
Brian, I. P. et al. 2005. 'Techniques for the identification of genes involved in psychiatric
disorders', Vol. 39, Australian and New Zealand Journal of Psychiatry
Hamshere, M. L. et al. 2012. 'Genome-wide significant association in schizophrenia to ITIH3/4,
CACNA1C and SDCCAG8 and extensive replication of associations reported by Schizophrenia PGC', Molecular Psychiatry, [Online] Available at http://www.ncbi.nlm.nih.gov/pubmed/22614287
Melanogaster Stubble Gene
The author of this scientific report has been asked to offer a thorough review of the stubble gene if a D. melanogaster. Items that will be covered will be a brief overview of the stubble gene, an introduction to the gene, the basic biological process when it comes to the gene, the phenotypic characteristics of the gene, the mode of inheritance of the gene, at least two mutant forms of the gene, the possible chromosomal effects of the gene, the molecular characteristics of the gene and any conclusions that can be drawn from the above. hile some may not be interested in the stubble gene in question, some of its attributes and behaviors are quite fascinating and intriguing.
Introduction of Gene
First off, the fly in question when it comes to all of this analysis can more easily be referred to as the fruit fly. This…
Anxolabachare, D. "Molecular Characteristics Of Diverse Populations Are Consistent With The
Hypothesis Of A Recent Invasion Of Drosophila Melanogaster By Mobile P. Ele...
Pubmed - NCBI." Ncbi.nlm.nih.gov. N.p., 2016. Web. 9 Oct. 2016.
Appel, L et al. "The Drosophila Stubble-Stubbloid Gene Encodes An Apparent Transmembrane
3.3 Data Collection
Is maternal UE3A active following iPS treatment: Data will be gathered on the iPS-treated mice via positron emission tomography, and in vivo brain slice preparation, and Western lot Analysis. H1 will essentially be ascertained following these tests.
Does iPS treatment rescue the motor and cognitive deficits associated with Angelman Syndrome: Data will be gathered from testing the treated mice in scientifically recognized tests of cognitive ability in a mouse model. This project proposes using the water maze test, the electric shock test, and the submerged platform test. H2 will effectively be answered using the data gleaned from these tests.
4.1. Potential Therapeutic and Other Considerations
The potential of using iPS treatment to rescue/alleviate the severe motor and cognitive deficits witnessed in Angelman Syndrome is theoretically viable. Reliable mouse models of AS exist with which to run the tests. The technology needed to tease iPS stem…
Abuhatzira, L., Shemer, R., & Razin, A. (2009). MeCP2 involvement in the regulation of neuronal alpha-tubulin production. Human Molecular Genetics, 1415-1423.
Condic, M.L., & Rao, M. (2008). Regulatory Issues for Personalized Pluripotent Cells. Stem Cells, 2753-2758.
Dindot, S., Antalffy, B., Meenakshi, B., & Beaudet, A. (2008). The Angelman syndrome ubiquitin ligase localizes to the synapse and nucleus, and maternal deficiency results in abnormal dendritic spine morphology. Human Molecular Genetics, 111-118.
Dobkin, B. (2007). Behavioral, temporal, and spatial targets for cellular transplants as adjuncts to rehabilitation for stroke. Stroke, 832-839.
The energy it stores (?180 Wh kg?1) at an average voltage of 3.8 V is only a factor of 5 higher than that stored by the much older lead -- acid batteries. This may seem poor in the light of Moore's law in electronics (according to which memory capacity doubles every 18 months), but it still took a revolution in materials science to achieve it. Billions of lithium-ion cells are produced for portable electronics, but this is not sustainable as cobalt must be obtained from natural resources (it makes up 20 parts per million of Earth's crust). (Armand & Tarascon, 2008, p. 653).
Fu investigated the lithium-ion conductivities of glasses and glass-ceramics in the LI2O-AlO3-TiO2P2O5 system. Fu's samples revealed high conductivity, albeit when Abrahams and Hadzifejzovic similarly investigated the LI2O-AlO3-TiO2P2O5 glass and glass-ceramic systems, their findings revealed "a maximum room temperature conductivity of 3.98 x 10-6 S/cm in their crystallized…
Armand, M & Tarascon, J.M. (2008). Building better batteries. Nature. Volume 451. Retrieved
April 17, 2010 from http://www.uio.no/studier/emner/matnat/kjemi/MENA5020/h08/undervisningsmaterial
Battery power. (2010). Royal Society of Chemistry (RSC). Retrieved April 17. 2010 from http://www.rsc.org/Education/EiC/issues/2008Mar/BatteryPower.asp
Translational medicine is a new discipline, which covers studies on basic science, on human investigations, non-human investigations, and translational research (Mankoff et al. 2004). asic science studies address the biological effects of medicines on human beings. Studies on humans discover the biology of disease and serve as foundation for developing therapies. Non-human or non-clinical studies advance therapies for clinical use or use in human disease. And translational research refers to appropriate product development for clinical use. Translational research looks into the identity, purity and potency of a drug product during early clinical trial (Mankoff et al.). Translating the knowledge derived from basic sciences into clinical research and treatments is the task of translational medicine (Nagappa 2006). There is a groaning need for this type of research on account of voluminous information in the information age. Using this information is the challenge encountered by scientists and healthcare providers everywhere in the…
Hersh, William. A Stimulus to Define Informatics and Health Information Technology.
Vol 9 BMC Medical Informatics and Decision Making: BioMed Central Ltd., 2009.
Retrieved on November 24, 2010 from http://www.biomedcentral.com/1472-6947/24
Mankoff, Stacey P. et al. Lost in Translation: Obstacles to Translational Medicine Vol 2
The accident occurred while the actress was taking a skiing lesson. She initial experienced no symptoms from her fall, but later complained of a headache and was taken to a local hospital. Reports indicate that her fall was not very spectacular and occurred at a low speed on a beginner run. She was not wearing a helmet at the time of the accident. (Quinn, 2009)
However, while it is true that sometimes there are no immediately obvious signs of a severe brain injury, at other times there are.
Severe Traumatic Brain njury
The symptoms of a severe traumatic brain injury (which can result in permanent neurological damage) include a number of cognitive problems including inability to concentrate, problems with memory, problems in focusing and paying attention, ability to process new information at a normal rate, a high level of confusion, and perseveration, which is the action of doing something over…
In describing the course of their patients, experienced clinicians who use HBOT to treat patients with brain injury, cerebral palsy, and stroke refer to improvements that may be ignored in standardized measures of motor and neuro-cognitive dysfunction. These measures do not seem to capture the impact of the changes that clinicians and parents perceive. Caregivers' perceptions should be given more weight in evaluating the significance of objective improvements in a patient's function. Unfortunately, studies have not consistently measured caregiver burden, or have assessed it only by self-report. Studies in which the caregivers' burden was directly observed would provide much stronger evidence than is currently available about treatment outcome. (AHRQ Publication Number 03-E049, 2003)
In other words, this somewhat alternative treatment produces results that are more meaningful to the injured person and his or her caregivers.
I have focused here primarily on the biochemical end of treatments for those with traumatic brain injury because it is this level of treatment that offers the long-term possibility of the greatest level of treatment. Such treatments as are described here have the chance to cure traumatic brain injury. But until these are perfected, every other kind of treatment and therapy -- from drug treatments to speech therapy to the love of friends -- will remain priceless.