Implications for ongoing research into genetic therapies and side effects/later developments are discussed at length.
Yannaki, E. & Stamatoyannopoulos, G. (2010). Hematopoietic stem cell mobilization strategies for gene therapy of beta thalassemia and sickle cell disease. Annals of the New York Academy of Sciences 1202: 59-63.

Though the clinical trial these two researchers are involved in does not yet have results that are ready for publication, the review of the risks they provide regarding the use of stem cell mobilization with G-CSF in patients with sickle cell is highly useful information. So, too, is the practice of pre-treating patients with hydroxyurea before administering the stem cell treatment, which the authors describe in detail and which forms the basis of the related clinical trial. Potential reduction of risks appears to be quite promising, though final results from the clinical trial and other supporting evidence will of course be required.

Ye, L., Chang, J.,….

Alterations of Hematology and Cardiovascular Systems
Sickle Cell Anemia

Ms. A is suffering from Sickle cell anemia. In this disease, the red blood cells appear in the shape of sickles or letter C. The normal red blood cells are disk-shaped. The disk-shape allows them to move smoothly in the blood vessels. Normal red blood cells have hemoglobin. The hemoglobin is responsible the red color. It helps in the transportation of oxygen. Sickle cells, on the other hand, have abnormally low hemoglobin, which results in the C-shape. This form is sticky and stiff and so cannot move easily through the blood vessels. Ms. A's condition was a case of Menorrhagia as well as dysmenorrhea. The sickle cells lump together and block the flow of blood through the blood vessels leading to the organs and the limbs. Such blocked blood vessels may lead to pain, infections and even organ damage (Health 24, 2014).

Sickle cell….

History of Pediatric Hemolytic Monitoring
Retrospect to the career of physician, Dr. James A. olff I and his early progress in treatment of Rh hemolytic disease as described in Pochedly (1984), looks at the development of interest in hematology in European field hospitals during orld ar II. After the war period, the transformation of olff's research in this area was advanced by research conducted during a pediatric residency at the Boston Children's Hospital, between 1945 and 1947. During his tenure at Children's he was engaged with Dr. Louis Diamond in his seminal investigation on treatment of erythroblastosis fetalis by exchange transfusion.

Collaborative efforts with Drs. Diamond and Farber focused on preliminary clinical trials of aminopterin for the treatment of acute leukemia, of which olff was in observation. Instrumental to the development of the concept of treating erythroblastosis fetalis by exchange transfusion; collaborative in the area of pathophysiology of disease where hemolytic….

Stem Cells
ithout a doubt, one of the most controversial topics of popular discourse is stem cell research. Indeed, one would be hard pressed to peruse the newspaper or magazine stand without encountering some reference to the global stem cell debate -- but what, exactly, are stem cells, and why are they so controversial?

Stem cells intended for use in human applications are harvested from humans, umbilical cords and embryos. The reason these cells are so valuable is because of their capability to produce or "become" other cell types -- for example, brain cells, heart cells, skin, etc. In short, these are "master cells," holding the ability to divide in cultures, and to be manipulated allowing it to transform into any type of cell. Of course, this is extremely important due to the fact that scientists can use this capability to either create organs (thereby helping to meet the tremendous shortage of….

Unfortunately, a tremendous amount of valuable research has been put on hold ever since the ban of federal funding for stem cell research. In the United States, the vast majority of medical research of all types that eventually lead to cures for disease are funded by the federal government. The federal ban on stem cell research does not completely prohibit it, but the effect is nearly the same, just as it would be if the federal government withdrew funding for cancer or diabetes research.

The main opposition to stem cell research comes from the Religious Right who believe that any form of research using fetal stem cells is wrong, because according to their religious views, every fertilized human egg should be considered as much a human being as any living person, even a microscopic zygote consisting of nothing more than four cells of human tissue. Certainly, the concept of religious freedom….

Huntington's disease (HD) was the first autonomic dominant disorder for which genetic prediction became possible" (Harper, et al., 2000, Journal of Medical Genetics, p. 567). HD is a disease that occurs due to an inherited disorder leading to the death of brain cells. A diagnosis of HD is accomplished through genetic testing which can be implemented at any age regardless of whether the symptoms manifest or not. Although, the specific symptoms vary between people, nevertheless, symptoms can start with people between 35 and 45 years of age and can also start in some individuals at even anearlier age. The disease may affect successive generations if health interventions are not implemented (Mandel, 2016).
Additionally, "the cause of HD is due to a dominant mutation of autosomal form of the gene called Huntington. This shows that a child born by an affected person has a 50% chance of developing or inheriting the disease"….

Hydroxyurea
Segal, J.B., et al., (2008), Hydroxyurea for the Treatment of Sickle Cell Disease,

Baltimore, MD: AHRQ

Variables/Key Concepts

To determine efficacy, effectiveness, harms, and barriers of the use of hydroxyurea treatment of sickle cell disease for determining solutions and further research need.

Sampling

Research studies based on variables.

Conducted by experts in sickle cell disease management, clinical trial methodology, systematic review, epidemiological studies, and ethics and adherence research.

Instruments/Data Collection

Instruments were quality assessment, data extraction, and evidence grading. Literature inclusion tailored toward research questions. Studies on children and adults evaluated separately. Included randomized trials, non-randomized trials, cohort studies with control groups, and pre/post studies. Evaluations of data was based on variable-based research questions.

Results

Hydroxyurea lowered the rate of hospitizations among children with sickle cell disease and raised HbF cell percentages.

Strengths/Limitations

Limited evidence for toxicity, barriers, and guide dosing. Insufficient evidence for efficacy and safety.

Critique

Even with the use of experts, there was no appropriate design method mentioned. Identifies research….

Cholecystitis
Biliary colic and cholecystitis are in the spectrum of gallbladder disease, ranging from asymptomatic gallstones to biliary colic, cholecystitis, choledocholithiasis, and cholangitis (Santen pp). hen gallstones temporarily obstruct the cystic duct or pass through into the common bile duct, gallstones become symptomatic and biliary colic develops, however, if the cystic duct or common bile duct becomes obstructed for hours or gallstones irritate the gallbladder, then cholecystitis develops, and when the stones become lodged in the common bile duct, choledocholithiasis occurs, resulting in possible cholangitis and ascending infections (Santen pp).

Cholecystitis is an inflammation of the gallbladder caused by obstruction, usually a gallstone, of the cystic duct, and the inflammation may be sterile or bacterial and the obstruction may be acalculous or caused by sludge (Santen pp). Bacterial infection is believed to be a consequence, not a cause, of cholecystitis, approximately 75% of bile cultures are positive, with the most common organisms….

The viruses that cause AIDS (HIV) and hepatitis can be carried in clotting factors however there have been no documented cases of such transmission in about ten years. Prevention of viruses can be prevented by: careful screening of donors; testing of donated blood products; treating donated blood products with a detergent and heat to destroy viruses (Hemophilia 2006). Both preventive and as-needed therapy can be administered at home, thus resulting in quicker treatment, fewer doctor or emergency room visits, and less costs. Vein access devices can be surgically implanted to allow easier access to a vein however infections can result from such devices (Hemophilia 2006).
All patients with bleeding disorders may benefit at times from using aminocaproic acid, an oral antifibrinolytic medication that helps stabilize clots (Curry 2004). Aminocaproic acid is the only product available in the United States in oral form, however it is not user-friendly, with dosing every….

H1N1
I chose this topic because the H1N1 virus and the swine flu have taken over the news. The Ohio Department of Health is heavily committed in getting the word out. "During the week of October 18-24, 2009, influenza activity continued to increase in the United States as reported in FluView. Flu activity is now widespread in 48 states. Nationally, visits to doctors for influenza-like-illness continue to increase steeply and are now higher than what is seen at the peak of many regular flu seasons. In addition, flu-related hospitalizations and deaths continue to go up nation-wide and are above what is expected for this time of year." (ODH).

The story is both a local and national headline. The television news report '60 Minutes' lead off this week's show with a serious discussion about all aspects of the new viral spread of the H1N1 virus and issues regarding the production process and current….

Human Genome Project
Launched in 1990 as a collaborative initiative between the National Institutes of Health and the U.S. Department of Energy, the Human Genome Project completed its goal ahead of time despite the enormous challenges that were involved (Greene, 2006). The goals of the Human Genome Project included developing comprehensive genetic and physical maps of the human genome in order to determine the complete nucleotide sequence of the three billion base pairs that make up the human DNA and to identify the estimated 100,000 genes that are contained within the human genome (Greene, 2006). To determine the importance and implications of the HGP, this paper reviews the relevant literature, followed by a summary of the research and salient findings concerning this initiative in the conclusion.

eview and Discussion

1)

How will research in the Human Genome Project further medical research? What disorders are most likely to benefit from the project?

To date, the….

Strokes and African-Americans
African-Americans are reported to be nearly twice as likely to experience a stroke as their white counterparts however, African-Americans are much less likely to know the risk-factors and symptoms of stroke or to seek early treatment. The purpose of this study is to examine the issue of African-Americans and stroke. The significance of this study is the additional knowledge that will be added to the already existing base of knowledge in this area of study. The methodology employed in this study is of a qualitative and interpretive nature and has been conducted through a review of literature in this area of study.

Strokes and African-Americans

African-Americans are reported to be nearly twice as likely to experience a stroke as their white counterparts however, African-Americans are much less likely to know the risk-factors and symptoms of stroke or to seek early treatment.

Purpose of the Study

The purpose of this study is to….

Maternity Nursing, Labor & Delivery / Newborn
Labor and Delivery Terms

Para: Para refers to the number of live births a woman has had (it might be a stillbirth, or twins, or even triplets) past the 20-week gestation period (Zimmerman, p. 116).

Gravida: this refers to the number of times a woman has been pregnant, whether she actually gave birth, had an abortion or a stillbirth (Zimmerman, p. 116).

Amniotic Sac: this is a membrane around which the fetus is surrounded. It is a strong series of membranes that is visible after 7 weeks of gestation. (Jurkovic, et al., 2011).

Cervical Effacement: this phrase refers to the measurement of the expansion of the cervix as the baby gets closer to being born. hen the cervix is 50% effaced, it is halfway to being ready for the baby to be born (Jurkovic, et al., 2011).

Cervical dilation: Slowly but surely the cervix begins to open (called dilation)….

Charles, K., Coustasse, A., & Willis, K. (2014). Does CPOE Increase Patient Safety by Reducing Medical Errors? Global Education Journal, 2014(1), 1-14.
The purpose of the research project was to determine if adoption of a CPOE system would be an effective elucidation to the problem of medical errors as well as determine what caused the medical errors.

The results pointed to reduction in adverse drug events and medical errors significantly using CPOE and demonstrate through review that CPOE provides a higher accuracy through ease of electronic use of data.

Evidence: By using information taken from previous research articles and studies, the authors determined CPOE can minimize medical errors and can be beneficial especially due to the financial incentives brought on by the HITECH Act of 2009.

Relation: This source supports other sources and evidence because it shows how beneficial CPOE is to patient care through reduction of medical errors.

Currency: This is a recent article….