Grant Proposal on Outcomes of fibrinolytic therapy vs. PCI Evidence-based medicine requires foundational inquiry and support. Heart disease, thrombolytic disease, pulmonary embolism, deep vein thrombosis, stroke and preliminary stroke occurrences and myocardial infarction are fundamentally significant challenges in medicine and community. Treatment of varied presentations of thrombolytic crisis deserve significant research inquiry and time given the severity of the potential outcomes and the numbers of individuals who seek treatment daily for heart disease and acute cardiac and venous crisis and the number of people who have both positive and negative medical and life outcomes during all levels of intervention. The various treatment options for acute and often potentially deadly cardiac crisis are often well tested and well established, yet they also require constant vigilance on the part of clinical researchers and practitioners to develop appropriate and best practices for best possible outcomes for patients. It is well established that outcomes of fibrinolytic therapy vs. primary percutaneous coronary intervention (PCI) vary with the most important functions of PCI being the immediacy of its performance, hence the door-balloon initiative contending that PCI be performed within 90 minutes of entrance for acute ST segment elevation myocardial infarction (STEMI) yet further research must be conducted to reiterate the importance of fibrinolytic therapy in concordance with PCI and also as an alternative when the door-to-balloon window has been bridged over time, be it from time of event beginning or time of treatment exposure. PCI treatment has been and will likely continue to be a well received and effective rapid treatment option yet it should not exclude fibrinolytic therapy as another viable option in a case by case scenario especially in cases where STEMI is identified after the door-to-balloon window has expired. This work will describe an historical review of acute treatment outcomes for those who have received exclusive fibrinolytic therapy or PCI.

Statement of Need

The work will reiterate the need for further and appropriate outcomes-based research and evidence based intervention in STEMI and other acute cardiac presentations....

The budget for the project will be 100,000 which will include minimal payment to the research team, time allocated for development of case work and minimal payment to physicians and participants, associated with the improvement of facility options and appropriations for acute cardiac treatment.
Evidence-based medicine requires foundational inquiry and support. Heart disease, thrombolytic disease, pulmonary embolism, deep vein thrombosis, stroke and preliminary stroke occurrences and myocardial infarction are fundamentally significant challenges in medicine and community. Treatment of varied presentations of thrombolytic crisis deserve significant research inquiry and time given the severity of the potential outcomes and the numbers of individuals who seek treatment daily for heart disease and acute cardiac and venous crisis and the number of people who have both positive and negative medical and life outcomes during all levels of intervention. The various treatment options for acute and often potentially deadly cardiac crisis are often well tested and well established, yet they also require constant vigilance on the part of clinical researchers and practitioners to develop appropriate and best practices for best possible outcomes for patients. It is well established that outcomes of fibrinolytic therapy vs. primary percutaneous coronary intervention (PCI) vary with the most important functions of PCI being the immediacy of its performance, hence the door-balloon initiative contending that PCI be performed within 90 minutes of entrance for acute ST segment elevation myocardial infarction (STEMI) identification. Further research must be conducted to reiterate the importance of fibrinolytic therapy in concordance with PCI and also as an alternative when the door-to-balloon window has been bridged over time, be it from time.

Project Description

Fibrinolytic therapy was the most logical and appropriate treatment for STEMI as well a other arterial and vascular crisis intervention prior to the availability of PCI treatment. Since that time Fibrinolytic therapy, despite its various advancements has been set aside as a viable first response to cardiac crisis. This is clearly a logical step in the progression of treatment and a clear…