ORGANELLAR AND CYTOSKELETAL
Organellar and Cytoskeletal Disease
One of the human cellular organelle disorders or diseases are known to the world is Cilia and Kartagener syndrome. It is a rare syndrome that occurs within the body with chronic sinusitis, situs inversus, and bronchiectasis (Mishra et al., 2012). The problem arises when the general movement of cilia is troublesome genetically due to its autosomal recessive genetic functioning. The patients have to suffer from chest infections, severe nose/throat/ear symptoms, and infertility.
Kartageners syndrome, also known as primary ciliary dyskinesia (PCD), shows an abnormal defect in the functioning of cilia. The symptoms include outer dynein arms, inner dynein arms, and sometimes even both when the problem occurs in 90% of the patients (Mishra et al., 2012). 38% of the patients have been investigated to carry mutations of dynein genes called DNAI and DNAH5. As mentioned earlier, the specific condition inculcates the buildups of secretions that result in frequent sinusitis, infertility, and bronchiectasis. It depends on the age when the symptoms are identified since sometimes the signs are present from childhood and never noticed. As the illness causes troubles in breathing due to its connection with the pulmonary system, the reversible airflow and its obstruction are a part of the syndrome. Clinically, the progression of the disease varies in each patient depending on the severity with which it hits the lungs and the fertility system, which in some cases, leads...
Quality of life and
life expectancy are more heavily dependent upon its successful diagnosis to prevent the severity of symptoms (Gupta et al., 2012).
The diagnosis process includes a picture of the chest for detecting chest infections, their severity, nature, the status of bronchitis and rhinitis becoming evident since childhood (Mishra et al., 2012). The prevalence of situs inversus in parents or siblings has to be known as a part of family history knowledge to recognize the probability of genetic inheritance. Also, the condition of liveliness and immobility is to be perceived on time. The reduction or absence of transbronchial mucociliary clearance is discovered along with cilia characteristics in ultrasound and electron microscopy (Mishra…
