¶ … Clinical Test for Celiac Disease
The sensitivity of a clinical test designed to discriminate between individuals with or without celiac disease would be based on its ability to correctly identify patients with the disease (Lalkhen & McClusky, 2008). In the example provided, 200 patients known to have celiac disease and 200 controls known not to have the disease were used to test the efficacy of the new clinical test. The results are as follows:
True positives = 190/200 = 0.95 or 95%
False positives = 50/200 = 0.25 or 25%
True negatives = 150/200 = 0.75 or 75%
False negatives = 10/200 = 0.05 or 5%
Sensitivity is determined by dividing true positives by the sum of true positives and false negatives (Lalkhen & McClusky, 2008), or in this example [190/(190+10)] = 0.95 or 95%.
The specificity of a clinical test describes its ability to exclude individuals from false positive results (Lalkhen & McClusky, 2008). Specificity is calculated by dividing true negatives by the sum of true negatives and false positives, or in this example [150/(150+50)] = 0.75 or 75%. The sensitivity and specificity for the new celiac disease test is therefore 95% and 75%, respectively, which would be considered highly sensitive and moderately specific.
The positive predictive value (PPV) of a clinical test is useful because it provides a numerical value for the likelihood that someone with the disease will test positive (Lalkhen & McClusky, 2008). PPV is calculated by dividing true positives by the sum of true positives and false positives, or in the example above: [190/(190+50)] = 0.792 or 79.2%. This is a good PPV because nearly 80% of individuals with the disease will test positive.
Applying the above sensitivity and specificity to a population of 10,000 individuals and disease prevalence rate sof 1% or 5%, result in the following data:
Table…
Adolescent Substance Use Screening Instruments: 10-Year Critical Review of the Research Literature Over ten million teenagers in the United States admit in a national survey that they drink alcohol, although it is illegal under the age of 21 in all states. In some studies, nearly one-quarter of school-age children both smoked cigarettes and drank alcohol. Over four thousand adolescents every day try marijuana for the first time. The dangers of use,
Population of the City of Atlantis on March 30, 2003 = 183,000 of new active cases of TB occurring between January 1 and June 30, 2003 = 52 of active TB cases according to the city register on June 30, 2003 = 238 The incidence rate of active cases of TB for the 6-month period was: [ONE POINT] per 100,000 population per 100,000 population per 100,000 population per 100,000 population 130 per 100,000 population 183,000
The subjects were adolescents 14-18 years old. They were recruited from schools and health clinics. The subjects completed an in-depth survey and interview at baseline and again 6 months later. The subsequent analyses were limited to adolescents with steady partners who reported sexual activity between the baseline and 6-month follow-up assessment periods (N = 179). At baseline, five-scale measures and a single-item measure were used to assess predictive constructs,
Self-Efficacy and Oppositional Defiant Disorder Oppositional Defiant Disorder The challenges of adolescence have always loomed large for young people and for families -- for as long as adolescence has been a recognized stage in human development. A constellation of skills is needed by young people to bridge the transition from childhood dependency to adult independency (Smith, Cowie, & Blades, 1998). For some young people, the transition is especially difficult and skill development
, 2010). This point is also made by Yehuda, Flory, Pratchett, Buxbaum, Ising and Holsboer (2010), who report that early life stress can also increase the risk of developing PTSD and there may even be a genetic component involved that predisposes some people to developing PTSD. Studies of Vietnam combat veterans have shown that the type of exposure variables that were encountered (i.e., severe personal injury, perceived life threat, longer duration,
Controversies in Neuroscience: Autism Clinical Neuroscience Controversies in Clinical Neuroscience: Autism Spectrum Disorders Controversies in Clinical Neuroscience: Autism Spectrum Disorders Although the U.S. Centers for Disease Control and Prevention (CDC, 2014a) and numerous medical organizations universally debunk the notion that vaccines contribute to the prevalence of autism, some sectors of the public refuse to let go of this belief and have even employed tactics designed to shut down opposing views ("Silencing debate," 2007). The
Our semester plans gives you unlimited, unrestricted access to our entire library of resources —writing tools, guides, example essays, tutorials, class notes, and more.
Get Started Now