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JNJ and Inflammation
Inflammation and its role in disease
Inflammation is a primary contributing component to the pathophysiology of allergies asthma (Barbers et al., 2012). Inflammation along with remodeling are defining features present with mild to severe asthma. Inflammation due to allergies causes structural and functional changes to blood vessels within the respiratory tract. These changes include increased blood flow, vasodilation, angiogenesis, and higher vascular permeability in airways of asthmatics (Jang et al., 2012). emodeling is defined as the structural changes that occur within airways such as increases in vascularity, increased smooth muscle mass within the airways, subepithelial fibrosis, and hyperplasia of goblet cells within the proximal and distal airways (Barbers et al., 2012). Furthermore, remodeling is a process involving a multitude of factors including complex interactions among cell adhesion molecules, cytokines, and growth factors (Jang et al., 2012). esearch has suggested that the structural changes that occur due to…… [Read More]
There are no diagnostic procedures that can specifically identify PID. However physicians rely on a number of symptoms that can be correlated in the diagnosis of PID. Diagnosis will begin with the physical examination of the abdomen. lood test is undertaken and in general there is an observed increase in the white blood cells. Around 50% of patients with PID have WC level greater than 10,000 and high ESR (erythrocyte sedimentation rate).[
Stephanie Abbuhl] DNA testing, fluorescent antibody testing and enzyme-linked immunosorbent assay tests can be used on cervical samples to identify the possibility of Chlamydial PID, while cervical samples collected on a medium of Thayer-Martin agar is used to identify gonorrheal infections. Ultrasound and laparoscopy tests are also indicated as they reveal inflammations and pelvic abscesses. However it is not possible to sufficiently examine the fallopian tube using laparoscopy hence diagnosis is not all that straight forward when the…… [Read More]
Blood vessels in the body also undergo changes during inflammation. These changes occur to maximize the movement of leukocytes, antibodies and platelets towards the injury site. It undergoes vasodilation, causing increase redness and heat because this process increases blood flow. The blood vessels become more permeable which causes the swelling or edema from the extravasated protein-rich fluid. This is a means of the body to bring the antibodies and other cells to the exact site of injury and perform their function. The changes in the blood vessels are mediated by a number of chemical mediators that cause this vascular leakage. They assert their function in the endothelial cells causing contraction, therefore letting the protein-rich, antibody containing fluid to escape toward the site of injury, and prevent further damage to the body.
Kumar, Vinay, et. al. obbin and Cotran Pathologic Basis of Disease. 7th ed. Philadelphia: Elsevier,…… [Read More]
This represents the end stages of the disease, where the body has destroyed it and begun the task of reconstructing what was affected during the viscous battle.
Depending on the severity of the injury or other cause of inflammation, these five stages can cause various symptoms within individual patients. The aggravation phase causes high fevers and heavy swelling within many individuals inflicted with various diseases and conditions. The phase of destruction normally produces such symptoms as puss, open sores, and abscesses. It can also cause permanent damage to the human body, if not the loss of life. The abatement stage is when many patients' fevers and other symptoms of inflammation begin to subside and lower, (Huether & McCane, 2008). The final stage brings about rebuilding of damaged tissue along with recovery of the patient. However, the severity of the infection will always determine the capability of recovery within each individual…… [Read More]
Infections of the implantation area the mainly widespread of the dental implant complications. Implant infection is a state which is known as peri-implantitis which has a sign of swelling or inflammation of the tissues adjacent to the implantation area. Peri-implantitis is a type of periodontal disease that is able to result to inflammation, bone loss and failure in dental implant in any case it is not treated appropriately. A flame is part of a fire. Inflammation is a situation where a tissue gets swollen, red, and frequently hurts. About dental implants, it is an inflammation that can be caused by trauma or infection. Inflammation causes several special defensive cells to move to the inflamed area. Inflammation is capable of resulting to bone loss together with dental implants, where bone loss is a dangerous situation. The supporting bone holds the dental implant in the jaw.
Generally, the purpose of the…… [Read More]
After 13 months, the rats begin to show signs of dementia including reduced cognitive ability and memory impairment (McGill University, 2010).
Amyloid B. immunotherapy
Past research on the effects of active or passive a? immunization on a? buildup and AD progression provided evidence that such immunization "protects against the progressive loss of synaptophysin in the hippocampal molecular layer and frontal neocortex of a transgenic mouse model of AD" (Buttini & al, 2005). This provided further support for the amyloid hypothesis.
Since the discovery of a? immunotherapy effectiveness in the treatment of AD in mice, the AN1792 a? vaccine was developed and tested on humans (Lemere & Masliah, 2010). Unfortunately, clinical trials were discontinued when around 6% of the subjects developed meningoencephalitis (Lemere & Masliah, 2010). However, since some subjects showed improvements in a? plaque clearance, several new a? immunotherapies have been developed and are currently undergoing…… [Read More]
The blood with the IgG must be effectively removed from the body, or reduced to levels that will not allow the cells to be a danger to the infant. If caught early enough, plasma transfers for the mother can result in enough of a reduction of IgG levels to forestall the effects to the fetus.
Autoimmune diseases occur when, for a variety of reasons, the body responds to its own cells as though they were dangerous foreign cells. In this way they are similar to an allergic response; an unrecognized but harmless entity is viciously attacked by the body in an attempt to destroy the perceived intruder. This is annoying (and possibly deadly) when it comes to allergies, and far more so when the body essentially becomes allergic to itself.
Though the reasons behind the onset of Type I diabetes are still not fully understood, the disease occurs when…… [Read More]
Macrophages also stimulate the production of white blood cells, particularly neutrophils. As these neutrophils die, they (along with dead cells, dead bacteria, and white blood cells) form a whitish material called pus. The appearance of pus indicates the body is attempting to fight the infection.
The tissue that results depends on the extent of the injury. If the injury is minor, the damaged tissue is replaced when fibroblasts form new collagenous tissue that heals the wound. Additionally, growth factor released by the connective tissue matrix stimulates the regeneration of tissue. However, if the wound is more extensive, scar tissue may result. Scar tissue is composed of collagenous tissue which is formed as a result of granulations developing in the damaged tissue.
D) as much as possible in your own words: What is prolotherapy? What does the physician do to the site of the damaged tissue? Why is it called proliferation…… [Read More]
GLAXOSMITHKLINE (GSK) - SUCCESSFUL INTENAL INNOVATION ead case study answer 4 questions . Do write a report. 1. Based GSK's past performance, critical implementation issues GSK internal innovation? Justify answer.
GlaxoSmithKline (GSK) -- Successful Internal Innovation
Critical implementation issues for GSK with regards to internal innovation
Implementation processes are complex endeavors which need to be thoroughly assessed and carefully decided upon. This is true in any situation and in the case of virtually all economic agents, but while this necessity is valid, it is to be differently approached and resolved across companies. In other words, the dimensions of a strategy to be implemented are sensitive to a wide array of organizational and situational particularities, including, among other things:
The size of the economic agent
The availability of resources (capitals, labor force, commodities and technologies)
The intellectual capitals possessed and the ability to gain, transfer and capitalize on knowledge
The access…… [Read More]
3. Growth factors can induce apoptosis by binding to their respective receptors (TKs). When activated, TKs in turn activate the as, af, MEK, MAPK, MKK, EK, Fos, JNKs, and Jun pathway, which can lead to the induction of AF via gene upregulation. AF in turn suppresses mdm2, a suppressor of p53 activity. The resulting increase in p53 activity can induce Bax, Mt, and thus apoptosis.
4. Adenomatous familial polyposis is caused by a truncated APC protein, which results from inherited mutations in the APC gene (Segditsas and Tomlinson, 2006). However, the activity of the wild-type or normal APC allele is usually sufficient to maintain tumor suppressor activity. For this reason, and because the wild-type allele is often found to have acquired somatic mutations, it is assumed that both alleles must be mutated before tumors can form. The vast majority of mutations found in colorectal tumors have retained 0 to 3…… [Read More]
bidder on a work contract may bid lower than what would maximize his/Her profit from the contract and the reason for that is to create goodwill
Ultimately, a contract is only as valuable as the signatures affixed to it. In other words, the risk of failing to gain a contract with a potentially valued partner is greater than the sum of revenue lost in the bid size. The best way to value the goodwill created by an amenable contract bid is by the length of the contract and the additional business that it generates with that client for clients referred by the present client.
From my personal experience attempting to gain contracts through an employment placement agency, providing an accessible starting bid for compensation can attract the attention of hiring companies. The goodwill and access generated by this kind of bid can ultimately lead to a more lucrative offer for…… [Read More]
Cardiac Stress Response: The Use of Anesthetic Technique to Promote Positive Outcome; Analyzing the Pros and Cons of Technique
Cardiac surgery by nature elicits a powerful stress response resulting from activation of stress hormones including epinephrine, norpinephine and cortisol hormones among others. Surgical trauma and blood loss may contribute to this stress response. Some surgeons have suggested that cardio pulmonary bypass surgery in and of itself activates an inflammatory response that results in a stress reaction.
The role of the anesthesiologist in cardiac surgery is to as much extent as possible, to reduce the stress response that results form cardiac surgery. Stress response can be mitigated by a variety of anesthetic technique, including use of opioids and epidural anesthesia. These ideas are explored in greater detail below.
Cardiac Stress Response: The Use of Anesthetic Technique to Promote Positive Outcome; Analyzing the Pros and Cons of Technique
INTRODUCTION stress response may…… [Read More]
This then leads to the activation of a number of genes whose products trigger cell-cycle arrest, apoptosis, or DNA repair" (Lakin 1999, p. 7644).
In research led by Hussain, he investigated the targets of free radicals, which are DNA, proteins, NA, and lipids. He noted that, "mutations in cancer-related genes or post-translational modifications of proteins by nitration, nitrosation, phosphorylation, acetylation or polyADP-ribosylation-by free radiacals or lipid peroxidation byproducts…are some of the key events that can increase the cancer risk" (Hussain 2003, p. 276). Furthermore, changes in DNA occur when the person has been exposed to high levels of nitric oxide or NO. p53 plays a role in that it acts as a mediator to stress but NO "causes p53 accumulation and post-translational modifications that inhibit cellular growth" (Hussain 2003, p. 278). His research has revealed that when exposed to NO during chronic inflammation sans wild-type p53, there might be increased…… [Read More]
Arthritic conditions found within the joints of the body: their causes, treatment, current research, and what effect they have on athletic participation.
Types of Arthritis
Causes of Arthritis
Arthritis and Athletic Activities
Arthritis is said to be the number one cause of disability in the United States, with more individuals disabled with arthritis than by both heart disease and strokes (Lewis 2000).
Arthritis is also a disease that is plagued with misunderstanding. The Center for Disease Control warns that it is these misunderstandings that result in the disease doing so much harm (Lewis 2000).
Some of the common misunderstandings involve recognizing that there are different types of arthritis and that arthritis is not only a disease of the aged. Arthritis is also often not taken seriously enough in its early stages, preventing individuals from seeking medical help that could…… [Read More]
Ankylosing Spondylitis is a chronic inflammatory condition that attacks young males. It may lead to the fusion of the spine (Sarker, 2016). The fusion can result in the spin being rigid thereby making the patient develop a hunched back. Subsequently, the patient may have breathing problems because of the posture. Other inflammatory signs may show up in other parts of the body such as the eyes (Sieper & Braun, 2010).
Etiology and Incidences
Ankylosing's etiology is still unknown but there are pointers to a genetic risk and component. esearchers have highlighted the association it has with the HLA B27 gene. They have proposed ineffective mechanisms but they are seen to be less apparent as is the case with reactive arthritis.
The prevalence of Ankylosing spondylitis in the general population is low (0.1% to 1.4%). It is more prevalent among Caucasians than in members of other races. Those suffering from chronic…… [Read More]
Cannabis contains more than one hundred and twenty distinct chemical compounds known collectively as cannabinoids. One of those canabinoids is cannabidol, commonly abbreviated and referred to as CBD. While CBD has no psychoactive properties, it may be beneficial for treating specific medical conditions including chronic pain. CBD can be used orally or topically. In its topical form, CBD is typically added to a carrier oil. Topical applications of CBD oils include the management of pain due to arthritis and inflammation. Research continues to mount suggesting the additional benefits of oral administration of CBD to treat epilepsy, multiple sclerosis, chronic pain, and anxiety. Because CBD does not produce known side effects, euphoric or otherwise, it has also garnered attention for its relative safety especially vis-a-vis its sister compounds found in cannabis. CBD also presents tremendous opportunities for market-related growth in the budding international cannabis industry.
Cannabidiol (CBD) is one…… [Read More]
A newer and easy test is the OSOM Vlue, which mixes a swabbed specimen from the vagina with a reagent. The test yields sialidase activity or presence in the vaginal fluid in 10 minutes. Sialidase is produced by V pathogens (Mashburn).
The most reliable criterion for detecting V is a pH>4.5 (Mashburn, 2007). A normal pH should, therefore, rule out V. A pH >4.5 can also indicate trichomoniasis or muco-purulent cervicitis. Vaginal inflammation more strongly suggests trichomonas or muco-purulent cervicitis, in turn associated with gonorrhea or chlamydial trachomatis (Mashburn).
The patient's pH level is 6, indicating V.
These are an inexpensive and relatively easy screening procedure for the most common sexually transmitted diseases, such as V (Iglesias, Alderman & Fox, 2000). The practitioner should be appropriately trained and experienced in using this procedure. Hence, the proper protocol and quality control are needed to insure accurate diagnosis.…… [Read More]
As a result, children and adolescents are at risk of delays and impairments in cognitive development" (Levy 2009). Such delays are far from inevitable, but they do underline the need to assure that Sarah 'keeps up' with her studies and that reasonable peer-appropriate learning goals may need to be met with the assistance of additional support in some instances.
Although not directly applicable to Sarah, immunizations with live viruses, including chickenpox, MMR (measles, mumps, rubella), and oral polio vaccines are not advised for children with lupus (Lupus, 2009, Children's Hospital of Boston). Sarah's parents may need to watch for is the possibility of symptoms in her sibling: "a form of lupus may occur at some point in about one out of twenty people whose siblings have lupus" and they may need to take this into consideration when contemplating a vaccination program if they ever have another child (Lehman 2002). Sarah's…… [Read More]
Biliary colic and cholecystitis are in the spectrum of gallbladder disease, ranging from asymptomatic gallstones to biliary colic, cholecystitis, choledocholithiasis, and cholangitis (Santen pp). hen gallstones temporarily obstruct the cystic duct or pass through into the common bile duct, gallstones become symptomatic and biliary colic develops, however, if the cystic duct or common bile duct becomes obstructed for hours or gallstones irritate the gallbladder, then cholecystitis develops, and when the stones become lodged in the common bile duct, choledocholithiasis occurs, resulting in possible cholangitis and ascending infections (Santen pp).
Cholecystitis is an inflammation of the gallbladder caused by obstruction, usually a gallstone, of the cystic duct, and the inflammation may be sterile or bacterial and the obstruction may be acalculous or caused by sludge (Santen pp). Bacterial infection is believed to be a consequence, not a cause, of cholecystitis, approximately 75% of bile cultures are positive, with the most…… [Read More]
Analyze the Pathophysiology of Asthma
The complex chronic inflammatory disease known as asthma, involves several inflammatory cells, more than a hundred distinct mediators of inflammation, and various inflammatory outcomes, such as plasma exudation, broncho-constriction, activation of the sensory nerves, and hyper-secretion of mucus. Mast cells contribute immensely to mediation of acute symptoms of asthma; on the other hand, T-helper 2 cells, eosinophils, and macrophages are factors that cause airway hyper responsiveness, by inducing chronic inflammation. It has been realized by an increasing number of researchers that structural airway cells, including smooth muscle and epithelial cells in airway, are a major inflammatory mediator source. Asthma involves several inflammatory mediators, such as growth factors, peptide and lipid mediators, chemokines, and cytokines. Chemokines have a crucial role to play in selective inflammatory cell recruitment from circulation, while cytokines coordinate chronic inflammation, which may cause structural airway modifications, including angiogenesis, sub-epithelial…… [Read More]
Homeostasis, according to Nirmalan and Nirmalan (2017), is the propensity for living organisms to maintain relative stability in the internal environment. Homeostasis is made possible through the cooperation of several regulatory mechanisms and separate sub-systems which make up the normal physiology of a living organism (Nirmalan & Nirmalan, 2017). During critical illnesses internal or external stress can make an attempt at interfering with the self-regulation systems beyond what is considered as normal range in physiology. According to Palaparthi and Med (2017), the word homeostasis is derived from two Greek words i.e. ‘homeo’ (stands for similar) and ‘stasis’ (standing for stable). Homeostasis is the balance, equilibrium and the stability of the body or of the cell (Palaparthi & Med, 2017). Living organisms exhibit this character. The process of maintaining stability in the internal environment necessitates occasional internal adjustments as the environmental conditions continue to change outside and inside the…… [Read More]
These biologically-based practices of alternative medicine include the use of vitamins, herbs, and food supplements found in nature, chief among which are probiotics: the living, beneficial bacteria found in the intestines. These benign bacteria counteract the presences of the malignant variety, which often cause digestive problems if allowed to overpopulate. Probiotics can be obtained as supplements or found in certain foods, and have been known to prolong periods of remission in ulcerative colitis patients, with no sever side effects.
The use of fish oils is another alternative medicinal treatment for ulcerative colitis. Fish oils contain omega-3 fatty acids, which are known for their anti-inflammatory properties (Crohn's & Colitis Foundation of America, 2011). Omega 3 fatty acids are found in certain green vegetables and in nuts, salmon, sardines and herring, as well as in oral supplemental form and are used to treat intestinal inflammation when ulcerative colitis is active. Aloe Vera…… [Read More]
Practical esearch Finding Implementation and Experimentation Stage -- Phase I
The experimenter did not set out to determine specifically which of the various contributing factors (or combinations of factors) identified by the empirical research of medial tibial stress syndrome was most responsible for the experimenter's symptoms. However, since the initial attempts to resolve the symptoms incorporated changes to all of the external variables except a change in running surface, the experimenter immediately sought a softer running surface and temporarily abandoned running on any hard surface that magnified instead of minimized the physiological trauma associated with running on harder surfaces.
Because the empirical research also implicated poor running stride mechanics and excessive vertical elevation, the experimenter devoted considerable attention to making the following specific changes to the running stride: (1) shorter strides to minimize travel of the body while neither foot is in contact with the running surface; (2) conscious attempts…… [Read More]
Like other researchers, the CCOHS notes that allergic reactions including inflammation, redness and formation of blisters may only appear after prolonged exposure to possible allergens; for some this may mean exposure to a substance for a few days before symptoms arise, for others exposure throughout a lifetime may result in some minor dermatitis (CCOHS, 10007). Typically, as others have confirmed, exposure is first necessary, then a process referred to as sensitization, where a worker may become "sensitized" to a compound they work with, the penetration of the epidermal layer of the skin, following an allergic reaction, a process which can take up to four weeks (CCOHS, 1997).
This process results when allergenic compounds binds to proteins naturally occurring in the skin, and lymphocytes or protective agents within the body react to protect the skin from damage; tissue-damaging chemicals called "lymphokines" may be released, which ultimately result in the symptoms commonly…… [Read More]
The patient is an 18-year-old of the Filipino-American origin. He has no known family history of ulcerative colitis or chronic illnesses similar to colitis. He is a high school senior student.
The patient complains of diarrhoea 3-4 times a month although it has been on and off for one year. There is no known allergy that the patient experiences.
He experienced rectal bleeding, rectal pain and often had an urgent need to empty his bowels. His diarrhoea had bloodstains with mucus at least once a month. This led to few red blood cells due to the low level of iron, which resulted from the bloody stool. He had belly pains, which he described as cramping and his belly felt sore if touched. He experienced constipation, but it was less frequent than diarrhoea. He had no signs of vomiting or nausea, but he…… [Read More]
In addition to the therapeutic armamentarium, CAM reported to have a great role to treat interstitial cystitis (IC). It is multimodal and individualized and includes various treatment methods including: Neuromodulation, dietary modification, acupuncture, surgical methods, medications etc. The objective of this literature review is to discuss the possible causes of the IC, diagnosis, prevalence, the symptoms, and CAM treatment options.
Interstitial cystitis (IC) also called as painful bladder syndrome is an inflammatory disease of the bladder wall with typical ulceration of the urothelium. The interstitial cystitis (IC) is generally regarded as an elusive disease picture with inadequate therapeutic options. Critical to improving the prospects for therapy is the early diagnosis of the disease, which may involve only a careful history taking and clinical examination. CAM suggests multimodal treatment strategies in the early stage of disease (Abrams, Cardozo, & Fall, 2002).
Due to definition similarity, IC is often referred…… [Read More]
Its use on those with acute PAH should be performed with caution. The complication rate was observed at 2%
in patients with acute PAH. The use of the procedure was deemed relatively safe for chronic pulmonary arterial hypertension. Severely ill patients should be subjected to non-invasive imaging method exhaustively before resorting to pulmonary angiography (Hofman et al.).#
Albert, Nancy M. Caring for Patients with Pulmonary Hypertension. Nursing:
Springhouse Corporation, May 1999. Retrieved on April 25, 2009 from http://findarticles.com/p/articles/mi_qa3689/is_199905/ai_n8846566/?tag=content;col1
adesch, David, et al. Medical Therapy for Pulmonary Arterial Hypertension.
131 (6). Chest: American College of Chest Physicians, July 20, 2007. Retrieved on April 25, 2009 from http://www.medscape.com/viewarticle/560041
Flattery, Maureen P. And Kathy M. aker. Evidence for Racial Disparity in Cardiac
Transplantation Survival Rates. Journal of Cultural Diversity: Tucker Publications,
March 22, 2004. Retrieved on April 26, 2009 from http://findarticles.com/p/articles/mi_m)MJU/is_1_11/ai_n6183827/?tag=content;col1
Hofman, Lawrence V., et al. Safety and Hemodynamic Effects of Pulmonary…… [Read More]
"Inflammatory Bowel Diseases (IBD) is a broad term that describes conditions with chronic or recurring immune response and inflammation of the gastrointestinal tract. The two most common inflammatory bowel diseases are ulcerative colitis and Crohn's disease" (IBD, 2013, CDC). Ulcerative colitis affects the large colon; Crohn's usually affects the small colon and the beginning portion of the large colon. egardless in both manifestations of IBD, the body attacks the cells of the intestine, mistaking 'good' things like food and bacteria for dangerous invaders and thus causing chronic inflammation.
The effects of IBD can be extremely severe because of the nausea, vomiting, diarrhea and subsequent weight loss and malnutrition that they cause. Crohn's is particularly dangerous because it can cause intestinal blockage from severe swelling and scaring. Ulcers can cause fistulas which become infected. Unlike lupus, both forms of IBD can be treated with surgery as well as various anti-inflammatory drugs.…… [Read More]
Multiple sclerosis or MS refers to an autoimmune, chronic condition which impacts physical movement, function and sensation. The problem sets in following neuron insulation destruction (i.e., myelin sheath destruction) within an individual’s central nervous system (CNS) (Cengage Learning, 2013). Symptoms of the disorder start showing up at early adulthood, greatly impacting patients’ domestic, social, and professional lives. As the absence of myelin retards action potential conduct, the disorder is manifested as performance impairment, having a potential destructive influence on patient behavior. MS often entails a relatively progressive onset of behavioral deficiencies and neurological symptoms (Hoang & Shepherd, 2010).
Multiple Sclerosis and Nervous System
Chronic, advancing cognitive deterioration within multiple sclerosis has been ascribed to a neuro-pathological, neurodegenerative disease process (in other words, diffused brain atrophy and axonal destruction). Additionally, atrophy and white matter lesions are known to play a significant part in cognitive dysfunction among individuals diagnosed with…… [Read More]
Structure and Function of the Respiratory System
Forty-five-year-old Brad has, ever since the age of 20, been working in the mines in the post of coal cutter. He is happy with his job as he earns a good wage and his father also worked in the very same mine. Akin to several co-workers of his, he suffers from chronic cough. However, Brad has neglected going for yearly health checks as is required for mine workers owing to his fear of being diagnosed with “black lung” (i.e., coal worker pneumoconiosis). This ailment results in fibrosis, lasting dilation of the small airways, and reduced diffusing capability. At more advanced stages of the disease, alveoli, airways and pulmonary capillaries get destroyed.
Chronic obstructive pulmonary disease (COPD)
COPD has been described as a persistent inflammatory lung ailment which obstructs flow of air from the patient’s lungs. Disease symptoms include difficulties in breathing, wheezing,…… [Read More]
This was finding of a research conducted on rats at the University of Rochester Medical Center in 2004. The research team, led by Dr. Maiken Nedergaard, worked on the premise that inflammation causes more irreversible and inevitable damage than the initial trauma (Henrich, Kelly, Reinhardt et al.).
The team injected the blue food dye into some of the experimental rats with spinal cord injuries (Reuters 2009, Takahiro 2009, Michaud 2009, Ehrenberg 2009). The rats at first began to move, hobbled about and turned blue. Rats, which did not receive the injection, did not walk or move at all. A substance, called ATP, is the source that keeps cells alive. The research showed that ATP runs out of control in spinal cord injury, activates an inflammation-causing molecule and kills spinal neuron cells. Treatment must be administered immediately after the injury. The experiment showed that rilliant lue G. blocks the action of…… [Read More]
It has also been suggested that low-level viral replication associated with SV may be a driver in chronic inflammation in some sufferers of chronic lung disease, although this is so far uncertain (Openshaw, 2005). It is estimated that infants who develop a wheeze as a result of SV contraction develop a recurring wheeze in around two thirds of all cases. It is also estimated that around half of these children will develop some form of asthma (Lehtinen et al., 2007). It is unclear why there are some who experience delayed onset of SV, although both immune 'imprinting' and viral persistence have been implicated (Openshaw and Tregoning, 2005).
The condition is diagnosed through rapid antigen-detection tests. It is difficult to diagnose SV in adults as the tests are insensitive in persons other than children, and practitioners rarely request tests for SV in adults. This means that it is difficult to…… [Read More]
John Frewin is a young child who lives with his parents. The 12-year-old is on a sustaining income of his parents. The parents of the child are low-income earners. The amount they receive can only sustain partial needs of the family thus aspects of the poor state of the society. John Frewin was diagnosis of Crohn's disease was at the age of 10 through a critical examination in the health institution. The main objective of this research exercise is to integrate ABCD's of nutritional assessment in the evaluation of Crohn's disease. Crohn's disease or Crohn syndrome refers to a condition involving inflammation of the lining of the digestive system (Ferrara & Saccomano, 2012). This disease affects the intestines as well as rare cases in any place from the mouth to the end of the rectum. The cause of Crohn syndrome is unknown. Despite this aspect, various elements might contribute…… [Read More]
hepatitis of the liver and how they are transmitted to how we can find a remedy to slow down the deterioration process if not cure it completely.
Causes of hepatitis B
Transmission of hepatitis B
Tests for hepatitis B
isk Factors for HCV Infection
Consequences of HCV Infection
Hepatitis is the disease connected with the inflammation of the liver. This disease was not discovered too long ago, however doctors and researchers have been able to find out the causes of hepatitis. There are several causes such as, viral, parasitic, infiltrative, drug or alcohol induced, or non-specific. Before a person is even diagnosed with this disease some of the prominent indications of the acute phase can be ranging from a symptomatic, where we may not even be able to notice we have hepatitis to feeling extremely tired, jaundice- where our skin…… [Read More]
Introduction person might wake up one morning and discover that one side of his or her face shows signs of paralysis. The symmetrical nature of the face might have a mismatched appearance. The afflicted side may have varying levels of deformity and droopiness.
The person might discover the inability to close the eye. The paralysis of one side of the face means that speech is often distorted. Feeding is difficult. Drooling is frequent. The person finds it impossible to pucker the lips into a shape that is often used for whistling. The direct diagnosis is that this person is suffering from ell's Palsy. This condition is relatively temporary. Only few people who suffer from this condition have permanent effects. ell's Palsy can develop over a few hours or a few days. It is not uncommon for a person to find that the condition has developed overnight.
Sr.…… [Read More]
insect with the highest protein content was the caterpillar, with 28.2 grams of protein per 100g. Americans at this point are unlikely to adopt insects as food in the near or even medium term. Objectively, the squeamishness factor doesn't make sense -- how on earth can someone eat a Big Mac and not eat a chapulines taco? Insects are infinitely cleaner and healthier than some of the crap people eat, and realistically ground beef that has been sprayed with ammonia, had color added back into it, and was raised pumped full of antibiotics and hormones is pretty nasty stuff. Bugs are nothing compared to that. There are a lot of people who are open-minded about food, but to overcome barriers is going to require creativity. Yes, chapulines are tasty, and in Vietnam they fry up locusts with pork fat, and these things are delicious, but Americans will need to see…… [Read More]
Gastric Acid Stimulation and Production
Pathophysiology of gastric acid stimulation and production
The parietal cells in the stomach are responsible for the production of gastric acid. Parietal cells contain secretory canaliculus, which produce gastric acid and release it into the gastric lumen. Gastric acid is produced as a response to the messages received through hormonal, paracrine, and neurocrine messengers (Schubert & Peura, 2008). The production of gastric acid undergoes three phases namely cephalic phase, gastric phase, and intestinal phase. Gastrin, the major hormonal trigger of gastric acid production is produced by the G cells located in the pyloric mucosa of the stomach. The G cells will release gastrin in response to a meal. However, the Histamine 2 receptors are thought to be the primary stimulus for the secretion of gastric acid.
How GED, PUD, and gastritis affect the stimulation and production of gastric acid
Gastroesophageal reflux disease (GED) is a…… [Read More]
Interstitial lung disease is a blanket term for a big group of disorders categorized by progressive scarring of both the lung tissue supporting and between the air sacs. This tissue is called the interstitium. The interstitium consists of the region between the alveolar space and the capillaries. The scarring causes inflammation and damage in the lung tissue followed by lung stiffness, meaning the air sacs cannot expand as much as before. Lung stiffness makes it harder to breathe. People affected by the condition are not able to get enough oxygen from the lungs into their bloodstream.
Although some potential causes have been researched, there may be no underlying cause for development of interstitial lung disease. If there is no known cause, it is called idiopathic interstitial lung disease. IPF or idiopathic pulmonary fibrosis remains the most common type of this illness. Of the causes most widely recognized, cigarette smoking is…… [Read More]
Arthritis is considered as one of the major health conditions affecting a significant portion of the United States population. Even though the condition currently affects approximately 50 million adults in the country, it is not primarily an adulthood health condition. There are numerous cases of children suffering from arthritis, which implies that this condition is not uncommon among children. As a result of the prevalence of arthritis among children and adults, understanding the pathophysiology and symptoms of this condition has emerged as an important component in proper diagnosis and treatment. This paper examines the pathophysiology of osteoarthritis and rheumatoid arthritis in relation to the similarities and differences between the two conditions. The analysis includes a selection of two patient factors that could impact the pathophysiology, diagnosis and treatment of these conditions.
Pathophysiology of Osteoarthritis and Rheumatoid Arthritis
Arthritis is an umbrella term that refers to different conditions involving inflammation of…… [Read More]
Pain, 56(1), 95-101.
Andrews, K., & Fitzgerald, M. (1999). Cutaneous flexion reflex in human neonates: a quantitative study of threshold and stimulus-response characteristics after single and repeated stimuli. Developmental Medicine and Child Neurology, 41(10), 696-703.
Breau, L.M., McGrath, P.J., Stevens, B., Beyene, J., Camfield, C., Finley, G.A., Franck, K., Gibbins, S., Howlett, A., McKeever, P., O'Brien, K., & Ohlsson, A. (2006). Judgments of pain in the neonatal intensive care setting: a survey of direct care staffs' perceptions of pain in infants at risk for neurological impairment. he Clinical Journal of Pain, 22(2), 122-129.
Bruce, E., & Franck, L. (2005). Using the worldwide web to improve children's pain care. International Nursing Review, 52(3), 204-209.
Carbajal, R., Gall, O., & Annequin, D. (2004). Pain management in neonates. Expert Review of Neurotherapeutics, 4(3), 491-505.
Chow, S.C., & Liu, J.P. (1998). Design and analysis of clinical trials: concept and methodologies. New York: John Wiley…… [Read More]
The Infectious Diseases Society of America or IDSA came out with guidelines on the treatment of the infection.
A multidisciplinary group, which prepared these guidelines, included infectious disease specialists, rheumatologists, neurologists, pediatricians, and entomologists. The guidelines primary apply to the disease strain acquired in the U.S. And do not tackle the diagnostic evaluation of the disease. They recommended oral and parenteral therapies according to a timetable. Doxycycline or amoxicillin, cefotaxime or penicillin would be prescribed. The guidelines warned against the use of first-generation cephalosporins, fluoroquinolones, and benzathene penicillin.
Greater Recovery Among Children
Studies conducted on 177 children treated for Lyme neuroborreliosis in an endemic area in Sweden showed that 117 of them recovered complete in two months.
The children exhibited fatigue, facial nerve palsy, loss of appetite and fever as symptoms. Antibiotics were given to 69% of the children. At 2 months, 117 of them recovered completely. At 6…… [Read More]
Question 5: Are there any sequelae as a result of acquiring the disease/condition?
Encephalitis itself is often sequelae. Secondary encephalitis can develops as a complication of a viral infection or reactivation of a latent virus, such as when the immune system is suppressed. Common diseases that can trigger secondary encephalitis include influenza, chickenpox, measles, mumps, and German measles (Encephalitis, 2008, Neurology Channel).
Question 6: Do you considered the disease/condition chronic or communicable?
The most common form of transmission in the U.S. is through herpes which is usually transmitted through human sexual contact. Mosquitoes and other insects can transmit the virus through bites and secondary conditions such as chickenpox that give rise to the virus are contagious.
Question 7: hy?
Herpes is an extremely common and contagious STD. Additionally, other forms of the virus are highly contagious through animal to human transmission, as in the case of the mosquito-borne est Nile…… [Read More]
The condition called Posterior Tibial Tendon Dysfunction (PTTD) denotes a flaw in the tendon functions directly supporting the foot, leading to the compensatory collapse of the arches. The condition is clinically explained as "an inflammation and/or overstretching of the posterior tibial tendon in the foot. An important function of the posterior tibial tendon is to help support the arch. But in PTTD, the tendon's ability to perform that job is impaired, often resulting in a flattening of the foot." (FP, 1)
Other implications to the condition will relate directly to the likelihood of pain and discomfort in the foot itself.
The improper distribution of weight and pressure in one's step can be the close for undue and excessive ground contact with load-bearing parts of the foot. The heel is especially vulnerable to inflammation and pain, contributing to the close connection between the presence of flat feet and the intrusion of…… [Read More]
Another hypothesis that has just began to be explored by the academic community is the possibility that flavonoids may alter growth factor signaling, thus limiting the ability of the cell to initiate rapid growth 8). Study into this area are just beginning to emerge and more information will be available in the next several years.
Potential Health Benefits
The key to solving the riddle of why persons that consume large amounts of fruits and vegetables can expect to have certain health benefits depends on the ability to understand the mechanisms at play. Let us first examine current hypothesis regarding the mechanisms that are responsible for the anti-carcinogenic effects of flavonoids. Research into the mechanisms by which certain flavonoids demonstrate anti-carcinogenic effects can be grouped into five categories. Currently these studies are at the in vitro stage, with a few animal studies in the present group. Therefore, it is not known…… [Read More]
"Given the rising prevalence of obesity with age in both childhood and adult life, the prevalence of adult obesity cannot be predicted from childhood data, but increasing childhood obesity heralds a greater health burden in adult life"(James & al 2001, p. 232S). Thus, the future focus is on child obesity and how it can be treated to bring well-being for the adult.
esearch for adipose cells is not at the beginning, but has become increasingly intensive in the last years. Obesity is rapidly spreading across the globe but all the scientific breakthroughs won't do magic in the presence of disinterest and neglect towards the human body, so the first step should come from each individual.
Albright, AL & Stern, JS 1998, "Adipose Tissue," Encyclopedia of Sports Medicine and Science, vol. 15
Bosello, O & al. 1980,"Adipose tissue cellularity and weight reduction forecasting," American Journal of Clinical Nutrition, vol. 33,…… [Read More]
prokaryotes consist of millions of genetically distinct unicellular organisms. A procaryotic cell has five essential structural components: a genome (DNA), ribosomes, cell membrane, cell wall, and some sort of surface layer which may or may not be an inherent part of the wall (1). Functional aspects of procaryotic cells are related directly to the structure and organization of the macromolecules in their cell make-up, i.e., DNA, RNA, phospholipids, proteins and polysaccharides. Diversity within the primary structure of these molecules accounts for the diversity that exists among procaryotes (1). Identifiable groups of prokaryotes are assembled based on easily observed phenotypic characteristics such as Gram stain, morphology (rods, cocci, etc.), motility, structural features (e.g. spores, filaments, sheaths, appendages, etc.), and on distinguishing physiological features (e.g. anoxygenic photosynthesis, anaerobiasis, methanogenesis, lithotrophy, etc.). Prokaryotes are commonly known as bacteria, and it is estimated that bacteria have been around for at least 3.5 billion years…… [Read More]
Increased tear production, inflammation, accumulation of blood, clouding of the cornea, burns.
Unlikely, due to gaseous state: frost-bite of the lips, mouth, and throat possible.
Upper airway irritation, cough, choking, shortness of breath, breathing difficulty, vomiting, narrowing of major airways, fluid in lungs, lung lesions, upper airway closure resulting in death, cardiovascular collapse due to low oxygen.
Irritation, ulceration, first, second, and third degree burns, frost-bite.
Chemical Name: Acetylene
Acetylen, Ethine, Ethyne, Narcylene
DOT Hazard Class:
In pure form, gas is odorless; commercial form, odor is garlic-like.
119°F, -84° C
Vapor:.906 (air=1), Liquid: N/A
0.00117 g/ml @ 0° C
Flammable Limits (% by volume)
Lower: 2.5, Upper: 100
Solubility in Water:…… [Read More]
Because some children have developed brain damage after the immunizations, some parents are concerned that the vaccine is responsible for neurologic impairment, however research does not indicate a definitive link between the pertussis vaccine and brain damage, although research is still ongoing (hooping 2005). Yet, as a precaution, children with a history of seizures or brain disorders may not be proper candidates for the DTaP vaccine (hooping 2005).
2001 study revealed that pertussis was the cause of chronic cough in 19.9% of the patients studied. Once a disease that ravaged children worldwide, whooping cough is once again on the rise (Green 2002). Today, approximately 300,000 children worldwide die every year from whooping cough, usually in areas where immunization rates are low (Green 2002). Nonetheless, even in the United States, where immunization rates are high, roughly 1 out of every 200 babies who get whooping cough will die from it, another…… [Read More]
he most common progressive chronic lung situations that would require the rehabilitation include interstitial lung disease, chest wall disease, bronchiectasis, and pre and post thoracic surgery. he fourth category of patients to offered pulmonary rehabilitation is those with recent exacerbation of COPD requiring hospitalization, without the anticipated recovery path, and whose functional baseline has changed significantly ("Service Specification," 2012).
Chronic lung diseases have developed to become one of the most common respiratory illnesses across the country. As the diseases have become one of the major reasons for hospitalizations of patients, they usually affect individuals at the age of 35 years and above despite of the fact that these individuals are usually not diagnosed until they are 50 years and above. he growth and rapid increase of chronic diseases is attributed to the tendency of many people with the disease not to get medical assistance. While the conditions continue…… [Read More]
Nursing - Asthma
The limitation of airflow in asthma is reported as "recurrent and caused by a variety of changes in the airway." (Expert Panel eport 3, National Heart, Lung, and Blood Institute, 2007, p.1) Those changes include: (1) bronchoconstriction; (2) airway edema; (3) airway hyperresponsiveness; and (4) airway remodeling. Expert Panel eport 3, National Heart, Lung, and Blood Institute, 2007, p.1) Airway edema occurs with the progression of the disease and the inflammation is more progressive and exacerbated by "edema, inflammation, mucus hypersecretion and the formation of inspissated mucus plugs as well as structural changes including hypertrophy and hyperplasia of the airway smooth muscle." (Expert Panel eport 3, National Heart, Lung, and Blood Institute, 2007, p.1) Airway hyperresponsivenss is reported to be "an exaggerated bronchoconstrictor response to a wide variety of stimuli. Airway modeling speaks of the permanent structural changes in the airway reported to be associated with "loss…… [Read More]
9/10/66 (46 years old)
Extremely painful headache that won't go away.
Deep pounding headache more pronounced behind eyes;
- Headache has lasted more than 72 hours
- OTC Pain medications ineffective (Tylenol)
No accompanying nausea or vomiting
Physical Exam: Elevated blood pressure
Diagnostic Testing: Frequency of symptoms log; More than 72 hours of pain; Two or more of unilateral, pulsating, moderate or severe pain; not reporting nausea or sensitivity to light; lack of response to pain medication
TMJ (Tempormandibular Joint Disorder)
History: Emanating pain but no jaw spasm or difficulty chewing or biting
Physical Exam: No clicking or popping of TMJ when opening or closing mouth
-No inflammation of muscle around jaw
Diagnostic Testing: No jaw pain or face pain, no earache so…… [Read More]
new respiratory drugs that have been approved for medical use over the past decade. The paper will highlight the diagnoses of the drugs i.e. when and why it is prescribed, how it is meant to be used and how often, its side effects, the impact for a missed dose or an overdose along with any other relevant information that will add depth to it appropriate use.
The main purpose for the respiratory drugs is to help cure the ailments directly or indirectly related to the functioning of lungs or general breathing of an individual. There are numerous sectors where studies on new respiratory drugs can be carried out and some of the most recent studies to include this particular aspect include allergies, asthma attacks, Acute espiratory Distress Syndrome (ADS), pneumonia and sinus infections.
In this paper we will focus on the following new respiratory drugs: Arcapta, Daliresp, Dulera, Tyvaso, Alvesco,…… [Read More]
Diabetic Vascular Disease state caused by the deficiency of a chemical in the body called insulin which is a hormone is called Diabetes. There are two forms of diabetes. In the type-one diabetes no insulin is formed and people require insulin injections for existence. This was once thought it would affect only children, but now it can occur at any age. The type2 diabetes is due to the resistance of the body towards the effects of insulin. This also includes insulin which is insufficient. ut in this type there is some amount of insulin produced. In both the types the blood glucose levels is increased. When compared to people without diabetes, people with diabetes are prone to certain problems. These problems occur in the nerves (neuropathy), kidney (nephropathy) and eye (retinopathy). These people are prone to early heart attacks and stroked due to the hardening of the arteries (arteriosclerosis). With…… [Read More]
Hyojung Lee, L.Ac.
Prophylactic Asthmatic Drugs and Traditional Chinese Formulas (EDIT)
Prophylactic Asthmatic Drugs and Traditional Chinese Formulas
In recent years there has been a notable increase in the diagnoses of allergies, asthma, and other diseases that affect the ability of people to breathe freely. The reasons for this are still the subjects of scientific debate and continued research. However, more effective drugs have been developed to treat the wheezing, shortness of breath, and other symptoms of allergies, asthma, and inflammation of the lungs. One of the most commonly-prescribed drugs for asthma is Cromolyn, otherwise known by its more popular brand name of Intal.
Cromolyn is usually inhaled through an atomizer as an aerosolized solution or is breathed in as a microfine powder. It inhibits the release of histamine, leukotrienes and other chemicals in the body that mediate inflammation. These chemicals are secreted from mast, macrophages, and other types of…… [Read More]
The idea of sitting being the new smoking is that evidence is mounting that sitting is unhealthy. In particular, being seated all day at work is an unhealthy practice. Constant sitting has a number of negative health outcomes, including back pain, reduced longevity, obesity and a number of other conditions.
NEAT is "non-exercise activity thermogenesis. This is energy that one needs to perform basic, everyday tasks such as doing dishes, standing in line or grocery shopping. When you are seated, you are not burning NEAT calories as efficiently, because the body has been signalled to basically stop using calories; in other words too much sitting conditions the body to being even more sedentary. NEAT helps to control weight because NEAT activities result in many more calories being burned in a day. Someone whose job entails them to be on their foot and relatively active can burn 1000 calories more…… [Read More]
Asthma and Stepwise Management
Long-term control and quick relief treatment, and the effect on patients
Health care comprises of giving treatment for acute asthmatic incidents and management of persistent symptoms, which includes exercise-provoked and nocturnal asthmatic symptoms. Pharmacological controls entail the application of management mechanisms: inhaled corticosteroids, theophylline, long-acting bronchodilators (anticholinergics and beta-agonists), leukotriene transformers and the more current tactics for example the utilization of Ige, that is, anti-immunoglobulin E. antibodies (Omalizumab), and the use of anti-IL-5 antibodies in the case of selected patients. Considering all and especially the most severely affected patients, the crucial objective is to minimize symptoms, reduce morbidity experienced from acute instances and negate psychological and functional morbidity to give a healthy or near normal life expected of a child's age (Morris, 2016).
Majority of the population with asthma have to depend on long-term control medications on a daily basis to aid prevent the symptoms. Most…… [Read More]
Pleural Effusion in Children -- An Overview
Pleural Effusion is a disease resulting from excess production of fluids or a decrease in absorption or in some instances both thereby leading to an abnormal collection of fluids in the pleural space. It is the commonest pleural disease and has etiologies that include symptomatic inflammatory, cardiopulmonary disorders and malignant diseases that require speedy evaluation as well as treatment (Jeffery ubins 2016).
Disorders like an infection are some of the primary afflictions that could lead to the collection of fluids in the pleural space leading to pediatrics pleural effusion. The fluid accumulation can result from poor absorption or an increase in filtration. While mild effusion is asymptomatic, complications like septicemia, pneumothorax, pleural thickening, bronchopleural fistula, and respiratory failure might accompany it (Shahla Afsharpaiman, et al. 2016). a chest ultrasound or lateral decubitus indicates the probability of the existence of a large pleural effusion.…… [Read More]
Patient’s chief complaint: A man aged 69 comes to the emergency room with a sharp pain to his chest’s left side, lasting between 30 and 40 mins and then subsiding.
History of present illness: The pain has woken him up thrice in the last 7 days. He claims the pain first started roughly six months ago. Initially, however, the pain used to surface only occasionally, commonly while he was doing gardening. The patient’s past medical history reveals a diagnosis of hypertension twenty-five years back.
Precipitating/alleviating factors: The patient has been smoking a half-cigarette pack daily for the last forty-five years.
Family History: The patient has lost two brothers and his dad to heart disease. The patient does not report any other significant illness history in the family.
Social History: His typical pastimes include sharing a drink with pals and gardening.
Review of Systems: From a physical examination of…… [Read More]
Asthma represents a lasting inflammatory airway condition characterized by hyper-responsiveness of the airways accompanied by repeated episodes of breathlessness, coughing, wheezing, and chest tightness. Such episodes have commonly been linked to airflow blocks which can be spontaneously reversed or sometimes require medication. Roughly three hundred million individuals worldwide suffer from asthma. Among children, boys exhibit greater asthma risk whilst among adults, women exhibit greater prevalence. A grasp of the condition’s pathophysiology (both acute and chronic forms) will facilitate an understanding of how to diagnose and treat patients suffering from it. Experts’ asthma pathogenesis knowledge has greatly evolved during the past twenty-five years with scholars discovering several phenotypes of the condition (Lynn & Kushto-Reese, 2015).
Pathophysiology of Acute Asthma
Acute asthma intensification, or asthmatic attacks, take place through binding of inhaled antigens to mast cells performing immunoglobulin E (IgE). These cells start degranulating, thereby releasing bradykinins, prostaglandins, leukotrienes, platelet-activating factors,…… [Read More]
Use tools and equipment that are properly designed to reduce the risk of wrist injury, (Zieve & Eltz 2010)
Workstations, tools and tool handles, and tasks can be redesigned to enable the worker's wrist to maintain a natural position during work, (National Institute of Neurological Disorders and Stroke 2010).
Ergonomic aids, such as split keyboards, keyboard trays, typing pads, and wrist braces, may be used to improve wrist posture during typing, (Zieve & Eltz 2010)
Training and awareness; the encouragement of frequent breaks; yoga classes offered for free at the workplace; job rotation.
Employers can develop programs in ergonomics, the process of adapting workplace conditions and job demands to the capabilities of workers, (National Institute of Neurological Disorders and Stroke 2010)
Nonsteroidal anti-inflammatory drugs, such as aspirin, ibuprofen, and other nonprescription pain relievers, may ease symptoms that have been present for a short time or have been caused by strenuous…… [Read More]