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Pre-Medications
Current practices in the Blood Marrow Transplant Unit (BMTU) are to administer Tylenol and/or Benadryl as pre-medications prior to the administration of blood products before a transplant takes place. This paper will study whether such pre-medicating actions are detrimental to the patient due to the masking effects of the medicines and the occurrence(s) of mostly mild reactions to the blood transfusions that are normal occurrences before BMTU surgery. The paper will seek to discern whether the practice of pre-medicating patients is a viable practice or one that needs to be changed or terminated.
The purpose of the study is to determine whether a change can be made to improve the care of patients undergoing bone marrow transplants. The improvement could take a number of different forms; two of those forms include; first a fewer number of reactions to the blood transfusions that take place before and during the transplant, and second the masking effects of the pre-medications would no longer be present.
The importance of the study is that the change, while not necessarily saving any additional lives, could ensure that patients who are already facing a long and arduous process can alleviate a small portion of the pain and suffering during the process. The easing of pain and suffering may not seem such a large consequence, however there...
The literature review is important because it can provide a direction to the study that will enhance the study's findings. An example would be a recent study that showed that "complications such as transfusion-transmitted infection and transfusion reactions remain drawbacks to the transfusion benefits gained by red blood cell (RBC) oxygen delivery and platelet (PLT) derived hemostasis" (Kennedy, Case, Hurd, Cruz, Pomper, 2008, p. 2285). If this study can assist in determining that pre-medications will lower transfusion reactions and infections, then the study will be of importance to the medical community.
Another study determined that "pre-treatments with intravenous clonidine suppressed the reflex cough induced by fentanyl" (Horng, Wong, Hsiao, Huh, Kuo, Cherng, Wu, 2007, p. 862). The study was conducted in response to a reflex cough that often develops after an intravenous bolus of fentanyl before surgery. A further…
References
Bringman, H.; Giesecke, K.; Thorne, A.; Bringman, S.; (2009) Relaxing music as pre-medication before surgery: a randomized controlled trial, Acta Anaesthesiologica Scandinavica, Vol. 53, Issue 6, pp. 759 -- 764
Horng, H.C.; Wong, C.S.; Hsiao, K.N.; Huh, B.K.; Kuo, C.P.; Cherng, C.H.; Wu, C.T.; (2007) Pre-medication with intravenous clonidine suppresses fentanyl-induced cough, Acta Anaesthesiologica Scandinavica, Vol. 51, Issue 7, pp. 862 -- 865
Kennedy, L.D.; Case, L.D.; Hurd, D.D.; Cruz, J.M.; Pomper, G.J.; (2008) Transfusion: A prospective, randomized, double-blind controlled trial of acetaminophen and diphenhydramine pretransfusion medication vs. placebo for the prevention of transfusion reactions, Tranfusion, Vol. 48, pp. 2285-2291
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