Sign Up Now
Get instant access to over 1 million+ study documents
OR
Already registered? click here to login
By creating your account, you agree to our terms of service, privacy policy and student honor code.
Introduction
Cystic fibrosis is a genetic condition with a primary symptom of excessive mucous production and resulting lung infections. It is “the most common fatal hereditary lung disease,” (Mall & Hartl, 2014, p. 1042). Symptoms and severity of the disease varies, but all cases are inherited. On the genetic level, cystic fibrosis is an “autosomal recessive disease caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR),” (Stoltz, Meyerholtz & Welsh, 2015, p. 351). There is no cure for cystic fibrosis, which can be deadly, but treatments for the disease have become more advanced, less invasive, and more effective.
Etiology and Risk Factors
Because cystic fibrosis is congenital, disease etiology is genetic. The disease is most prevalent among Caucasians of Western European ancestry. Cystic fibrosis is known as a Mendelian condition, a disease that is actually caused by only one single gene dysfunction or mutation (Cutting, 2015). Being a carrier of CFTR mutations is the only known risk factor for the disease. The disease can be present long before symptoms manifest (Stoltz, Meyerholtz & Welsh, 2015). Therefore, genetic testing may be a critical component in ensuring early interventions to minimize symptom severity and promote longer and better quality of life for patients. In the United States, newborns are routinely screened...
The excessive mucous clogs essential airways and digestive tracts, leading to lung infections, inability to breathe, and inability to eat or process food.
In a healthy body, cells produce mucous, sweat, and other bodily fluids for lubrication and other functions. Cystic fibrosis is a condition whereby the genetic abnormality causes the mucous secretions to become abnormally and detrimentally thick. The thick secretions clog up critical passageways in the lungs and pancreas. In fact, CFTR dysfunction “may be implicated in the pathogenesis of chronic obstructive pulmonary disease,” (Mall & Hartl, 2014, p. 1042).
Cystic fibrosis “alters the electrophysiological properties across airway epithelia,” (Stoltz, Meyerholtz & Welsh, 2015, p. 353). In addition to air passage clogging, which leads to impeded breathing and lung infections, people with cystic fibrosis also experience digestive problems that can result in malnutrition-related illnesses.
Clinical Manifestations and Complications
Because of rigorous screening procedures in the United States, cystic fibrosis is detected in infancy through genetic, blood, and…
References
Cutting, G.R. (2015). Cystic fibrosis genetics: from molecular understanding to clinical application. Nature Reviews Genetics 16: 45-56.
Mall, M. A. & Hartl, D. (2014). CFTR: cystic fibrosis and beyond. European Respiratory Journal 2014(44): 1042-1054.
Stoltz, D.A., Meyerholtz, D.K. & Welsh, M.J. (2015). Origins of cystic fibrosis lung disease. The New England Journal of Medicine 372(4): 351-362.
Cystic Fibrosis (CF) is genetically inherited through a defective gene, which results in the body producing "abnormally thick and sticky fluid, called mucus. This mucus builds up in the breathing passages of the lungs and in the pancreas, the organ that helps to break down and absorb food." (PubMed Health, 2011) Reports state that millions of Americans carry the defective Cystic Fibrosis gene however; most do not have any symptoms since
Cystic Fibroids Cystic fibrosis Cystic fibrosis is a disease that can be passed down from one generation to the other. It affects secretary glands that produce mucus and sweat. The disease results after the fibrosis transmembrane conductance regulator (CFTR) gene that is found on chromosome 7 has undergone some sort of mutation. Mutation on chromosome 7 alters the production and function of CFTR glycoprotein (Scott, 2013). Studies have identified more than 1600
Cystic Fibrosis is an inherited disorder which affects the secreting abilities of various glands in the body. These glands are the ones that are considered with both mucus and sweat made in the made. This disease presents with many different symptoms as it affects the lungs, intestines, liver, pancreas, sinuses and the genitals. This paper will go on to talk about the basic etiology of Cystic fibrosis. After the discussing
healthy individual is infected with a bacteria or virus, the body identifies the virus as an invader, and therefore produces the antibodies, which is the human body's immune system, to destroy the virus to assist the person to recover and become healthy. Meanwhile, vaccination is the process of stimulating the active immune system to fight disease in the body, and vaccine will boost the body active immunity to fight
COPD Chronic obstructive pulmonary disease (COPD) year-old male -- pt known to me -- recently admitted to the ward with Non-STEMI & LVF. Discharged five days ago. Was found collapsed in his house by his niece. Duration not known. Could not get up from the floor, no chest pain/SOB. No dysuria/constipation -- ? Incontinence Pt was discharged with a package of care last week. Detailed history not available as the pt is confused and not answering any
Management of Immunocompromised Patients In beginning I writer specific nursing assignment. The Question: 2000 Words While clinical placement asked prepare a single room an admission. The patient requiring admission isolation room immunocompromised. Immunocompromised patients usually require isolation in order to prevent them from becoming infected with infections from other patients which is known as protective isolation. For the immunocompromised patients, their immune system is unable to fight the infectious diseases. There are