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Part 1
Cellulitis, as Sullivan (2018) points out, happens to be an acute skin infection that largely affects the subcutaneous and dermis tissues. In the present scenario, the patient developed the symptoms described as a consequence of the entry of bacteria through the laceration/cut in the leg. According to Kellerman and Rakel (2018), there are two kinds of bacteria that are responsible for a majority of cellulitis cases, i.e. staphylococcus aureus and streptococcus. Once the organisms gain entry, defensive cells are overwhelmed. Under normal circumstances, the defensive cells are often instrumental in the containment and localization of inflammation. As a result, there is the accumulation of cellular debris. It is important to note that in the present case, tissue around the cut (point of entry) could have been invaded by the organism as cellulitis progressed.
Part 2
In the words of Herchline (2019), “immunogenetic factors may play a role in some families who have an underlying susceptibility to an infection progressing to cellulitis.” This is an assertion further advanced by Coleman and Neilsen (2019) who also points out that infection susceptibility is in some instances influenced by the genetic factors of the host. Given that a significant proportion of infections in this case are reported in immunecompromised patients, it is the immune response genes that may be associated with the disease progress. Further, it would also be prudent to note that “cellulitis has been reported in about 10% of individuals with deletion 22q13 syndrome” (Carey, Cassidy, Battaglia, and Viskochil, 2020, p. 330).
Part 3
Essentially, immunosuppression could be conceptualized as the repression of a person’s immune system and its infection-fighting abilities. This essentially leaves the body incapable of initiating meaningful or appropriate immune responses. This is more so the case given that the immune cells are rendered incapable of producing immunoglobulins.
References
Coleman, K. & Neilsen, G. (2019). Wound Care: A practical guide for maintaining skin integrity. Elsevier Health Sciences.
Carey, J.C., Cassidy, S.B., Battaglia, A. & Viskochil, D. (Eds.). (2020). Cassidy and Allanson's Management of Genetic Syndromes. John Wiley & Sons.
Herchline, T.E. (2019). Cellulitis. Med Scape. https://emedicine.medscape.com/article/214222-overview#a4
Kellerman, R.D. & Rakel, D. (2018). Conn’s Current Therapy. Elsevier Health Sciences.
Sullivan, T. (2018). Diagnosis and management of cellulitis. Clin Med., 18(2), 160-163.
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