Nitric oxide (NO) is involved in redox signaling in ways somewhat similar to hydrogen peroxide (H2O2); both are purposefully produced toxic elements used to cleanse wound areas of infectious agents and used to signal other healing processes to start, while at the same time becoming dangerous in and of themselves if not properly regulated (Nunoshiba et. al., 1993; Forman & Dickinson, 2003). Though nitric oxide is not involved in as many individual processes as hydrogen peroxide, or at least a lower number of processes have been identified in current research, its presence in too great an abundance can disrupt proper signaling and trigger alternative signaling pathways other than those normally utilized in redox signaling (Forman & Dickinson, 2003). These redox signaling pathways have the potential to promote the continued production of reactive oxygen species rather than contributing to the continued progression of the optimal redox signaling cascade, in which the production of NO, H2O2, and other reactive oxygen species would be signaled to cease and normal intercellular environments would resume (Forman & Dickinson, 2003).

Conclusion

Research into the complexities of redox signaling in wound response and its implications for the healing process remains ongoing, and many current findings are still the product of a great deal of conjecture. Still, enormous advancements have been made in this area of biochemical knowledge. As redox signaling and other aspects of wound healing are better understood, more effective methods for dealing with infections and slow healing times can be developed, and many in the world will truly experience better living through chemistry in a very direct way.