Cell Essays (Examples)

Filter results by:

 

View Full Essay

Structure and Function of the P53 as a Tumor Suppressor

Words: 1740 Length: 7 Pages Document Type: Essay Paper #: 48537246

Tumor Suppressor p53
The p53 tumor suppressor, also known as the TP 53 or tumor protein can be referred to as a gene that codes for a protein that is responsible for the regulation of the cycle of the cell and therefore acting as tumor suppression. It is significant for cells in multicellular organisms to suppress cancer, p53 has been referred to as ‘the guardian of the genome’ as extracted from its role in the conservation of the stability by hindering the mutation of the genome. The name p53 comes from the molecular mass that it has-53 kilodalton fraction of the cell proteins.
The research conceited with the cure for cancer and its management dates many decades ago, but in 1979 there was a significant breakthrough. There were six groups of investigators each working separately and independent of each other came to an amazing similar discovery of a 53 kDa…… [Read More]

References

Bioinformatics (2017). Primary Information of p53. Retrieved November 24, 2017 from http://www.bioinformatics.org/p53/introduction.html

Hollstein M. and Harris C.C., (1993). Clinical Implications of the p53 Tumor-Suppressor Gene. Retrieved November 23, 2017 from http://www.nejm.org/doi/full/10.1056/NEJM199310283291807

Freed-Pastor W.A. & Prives C., (2017). Mutant p53: one name, many proteins. Retrieved November 23, 2017 from http://genesdev.cshlp.org/content/26/12/1268.full

Nature Education, (2014). p53 : The Most Frequently Altered Gene in Human Cancers. Retrieved November 24, 2017 from https://www.nature.com/scitable/topicpage/p53-the-most-frequently-altered-gene-in-14192717


View Full Essay

Analyzing the Eukaryotic Chromosome

Words: 653 Length: 2 Pages Document Type: Essay Paper #: 12450704

Structural Elements of a Functional Eukaryotic Chromosome
The three essential structural elements of a functional eukaryotic chromosome are centromere, telomeres, and origins of replication. Centromere serves as the attachment point for the spindle fibers. A centromere is a region of DNA responsible for the movement of the replicated chromosomes into the two daughter cells during meiosis and mitosis. Joining the sister chromatids is one of the major functions of the centromere. The two copies of the replicated chromosome are referred to as sister chromatids, and they stay joined together until they are physically pulled into the two future daughter cells, which ensures that each daughter cell will receive exactly one copy of each chromosome. The second major function of the centromere is to attach the microtubules in the mitotic spindle. The centromere will direct the formation of the kinetochore. The kinetochore is a special protein structure that attaches to the…… [Read More]

References

Hamperl, S., & Cimprich, K. A. (2014). The contribution of co-transcriptional RNA: DNA hybrid structures to DNA damage and genome instability. DNA repair, 19, 84-94.

Hennig, W. (2013). Structure and Function of Eukaryotic Chromosomes. Heidelberg, Germany: Springer.