Sickle Cell Anemia: Ethical Considerations The only known cure for sickle cell disease is hematopoietic stem cell transplant (HSCT). Survival rates after HSCT are high, almost 100%, with cure rates of more than 90% (Nickel, Hendrickson & Haight, 2014; Nickel & Kamani, 2017). To receive HSCT most successfully, the donor is ideally a HLA-identical sibling. This raises several ethical concerns. The most pressing of all ethical concerns related to HSCT is whether the procedure should be offered to children with “less severe” cases of sickle cell disease (Nickel, Hendrickson & Haight, 2014; Nickel & Kamani, 2017). Less severe cases have been defined as those that do not have overt complications. However, Nickel, Hendrickson & Haight, (2014) point out that many “less severe” cases may become more severe over time, compelling healthcare workers to offer HSCT to all children with sickle cell disease. The same issue of access to HSCT is related to adult cases of sickle cell, cases from low income countries, or cases where the potential recipient has “social problems” that might significantly impact health outcomes (Nickel & Kamani, 2017). Another potential ethical issue has to do with the deliberate use of reproductive technologies to create the HLA-identical donor (Nickel & Kamani, 2017). Healthcare workers should take care to preserve...
Resources are scarce with HSCT, until new research in cryobiology and cryopreservation reduces the ethical and financial burden, as well as the physical and psychological burden of donor transplants.References
Hoban, M.D., Cost, G. J., Mendel, M, C., et al (2015). Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells. Blood 2015(125): 2597-2604.
Holmes, M.C., Reik, A., Rebar, E.J., et al (2017). A potential therapy for beta-thalassemia (ST-400) and sickle cell disease. Blood 2017(130): 2066.
Lavery, S.A., Islam, R., Hunt, J., et al (2016). The medical and ethical challenges of fertility preservation in teenage girls. Human Reproduction 31(7): 1501-1507.
Nickel, R.S., Hendrickson, J.E. & Haight, A.E. (2014). The ethics of a proposed study of hematopoietic stem cell transplant for children with “less severe” sickle cell disease. Blood 2014(124): 861-866.
Nickel, R.S. & Kamani, N. (2017). The ethics of hematopoietic stem cell transplantation for sickle cell disease. In Meier E., Abraham A., Fasano R. (eds) Sickle Cell Disease and Hematopoietic Stem Cell Transplantation, Springer, pp. 199-219.
III. Considering Current Challenges As noted during the introductory chapter of this proposal, children routinely note how their parents cope with pain; their particular pain coping styles. During the implementation of this proposed study, this researcher expects to create a questionnaire... exploring the way parents of adolescents afflicted with SCD personally handled their pain. Both parents and adolescents will be solicited to contribute to the following components will the condensed/adapted to
Essay Topic Examples 1. The Genetic Basis of Sickle Cell Anemia and its Inheritance Patterns: This essay will dissect the genetic underpinnings of sickle cell anemia, detailing the specific DNA mutation in the HBB gene responsible for the abnormal hemoglobin formation. The focus will be on how the disease is inherited in an autosomal recessive pattern and the implications for carriers and affected individuals. 2. Sickle Cell Anemia:
Essay Topic Examples 1.The Genetic Basis of Sickle Cell Anemia: This essay would explore the genetic mutation responsible for sickle cell anemia, how the disease is inherited, and the molecular mechanisms leading to the characteristic sickle-shaped red blood cells. It would also discuss the prevalence of the mutation in different populations and the evolutionary theory of the heterozygote advantage in areas with malaria. 2.Managing Pain in Sickle Cell Anemia Patients: The essay would delve
Essay Topic Examples 1. The Genetic and Molecular Basis of Sickle Cell Anemia: Explore the hereditary factors of sickle cell anemia, including the mutation in the HBB gene that leads to the production of abnormal hemoglobin. Discuss the implications of this mutation on the red blood cells and the resultant pathophysiology. 2. Sickle Cell Anemia and Its Global Health Impact: Analyze the prevalence of sickle cell anemia in various regions around the world and
Nurses Perception: Effects of the New Sickle Cell Disease Program on the Management and Care Ofadults With Sickle Cell Disease Description of the relationship between extant literature and the hypothesis Description of the research design Description of research methodology Description of study subjects Description of Instrumentation or Treatment Description of data collection procedures Nurses Perception: Effects of the New Sickle Cell Disease Program on the Management and Care of Adults with Sickle Cell Disease. The purpose of this
Huntington's disease (HD) was the first autonomic dominant disorder for which genetic prediction became possible" (Harper, et al., 2000, Journal of Medical Genetics, p. 567). HD is a disease that occurs due to an inherited disorder leading to the death of brain cells. A diagnosis of HD is accomplished through genetic testing which can be implemented at any age regardless of whether the symptoms manifest or not. Although, the specific
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