What Are the Pathological Hormonal Imbalance Effects Fsh Follicle Stimulating Hormone  Term Paper

Excerpt from Term Paper :

pathological hormonal imbalance effects of follicle stimulating hormone (FSH), one first needs to know what FSH is. This essay, accordingly, starts off with describing FSH before proceeding with a description of how FSH imbalance affects the body and providing concise description of the hormone, the target organs, and the cells. The essays also describes the types of receptors that are affected with the imbalance (i.e. The specific cellular effects); the mechanism that is being affected, and the type of receptors that are interfering with the mechanism.

Follicle stimulating hormone (FSH)

FSH is a hormone found in humans and animals that regulates the growth, development, pubertal maturation, and reproductive processes of the body. It is synthesized and secreted by gonadotrophs of the anterior pituitary gland. FSH is intimately involved in reproduction by stimulating maturation of germ cells in both males and females and, in females, by initiating follicular growth. By leveling the decline in the late follicular phase, it selects only the most advanced follicle to proceed to ovulation.

There is also a slight rise in DSH at the end of the luneal phase in the females that is significant in starting the next ovulatory cycle.

Follicle stimulating hormone is usually measured in early follicular phase at the beginning of the menstrual cycle, which is usually the third to the fifth day from the last menstruation. Also known as basal FSH levels, levels of estradiol and progesterone are then at their lowest point.

Pathological hormonal imbalance effects of follicle stimulating hormone

High serum FSH concentration is, in health normal situations found in a female who is experiencing or who has recently experienced menopause. High levels indicate that the normally restricting influence of the gonad is absent, resulting in liberated and unimpeded pituitary FSH production.

Abnormal high levels of FSH are declared as such when they are seen during the reproductive years. The mechanisms associated with this include:

1. Premature menopause, which is also known as premature ovarian failure -- sometimes having a genetic origin, this, is loss of the ovaries before 40. Reasons maybe attributed to amenorrhea, hypergonadotropinism, and hypoestrogenism.

2. Castration -- female loses function of ovaries or male loses function of testicles.

3. Poor ovarian reserve, otherwise known as premature ovarian aging -- low reproductive ferity characterized by few oocytes in ovaries or impaired preantral cycle. Quality of eggs may also be corrupted.

4. Gonadal dysgensis (i.e.…

Sources Used in Document:


Boulpaep EL, Boron WF (2005). Medical physiology: a cellular and molecular approach. St. Louis, Mo: Elsevier Saunders.

Fowler PA, Sorsa-Leslie T, Harris W, Mason HD (December 2003). "Ovarian gonadotrophin surge-attenuating factor (GnSAF): where are we after 20 years of research?." Reproduction 126 (6): 689 -- 99.

Dr. Licciardi FSH and Estradiol (Estrogen). Infertility blog.


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