This paper addresses several foundational topics in biological psychology drawn from Kalat's Biological Psychology. It examines how progesterone and estrogen regulate mammalian fertilization and pregnancy, explaining why estrogen alone cannot serve as the determinant hormone in reproduction. The paper then considers how blocking dopamine synaptic activity would likely suppress sexual motivation and performance. It also proposes a research design to investigate the reported higher IQ scores of intersex individuals, emphasizing the importance of controlling for familial-intellectual background. Finally, it critically evaluates Simon LeVay's study linking hypothalamus size to sexual orientation, noting the study's inability to establish causal direction.
Fertilization requires a male sperm to penetrate the outer membrane of the female ovum. According to Kalat, sperm use progesterone as a kind of chemical beacon and are inherently drawn to its receptor signals. When the release of the progesterone hormone is blocked by RU-486, sperm are unable to make the critical initial contact that would ultimately lead to pregnancy.
Kalat indicates that the hormonal mechanisms differentiating gender in mammals are critical for promoting connectivity between parents and the expected newborn. In particular, estrogen cannot function as the sole determinant hormone in mammalian reproduction because the female parent's hormonal cycles shift dramatically and regularly over the course of pregnancy. According to Kalat, "in addition to secreting hormones, the female changes her pattern of hormone receptors. For example, late in pregnancy, her brain increases its sensitivity to estradiol in the areas responsible for maternal behavior" (p. 325). As these patterns change to facilitate both the survival of the mother and the development of the fetus simultaneously, inconsistent estrogen levels are common. Therefore, mammalian dependency on estrogen as a primary regulatory hormone would disrupt the gender selection process.
Because dopamines are essential pleasure-receptor hormones, any treatment that blocks their activity would also likely diminish the subject's ability to experience pleasure. As dopamine is a key driver of sexual motivation, desire, potency, and performance, blocking activity between dopamine synapses would likely disrupt the subject's sex drive.
"Proposed study design for intersex IQ research"
"Critique of LeVay's hypothalamus and orientation findings"
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