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Studies have shown that Lisofylline, an anti-inflammatory compound is very effective in suppressing the autoimmune activity and in improving the islet secretion of insulin. Mice studies showed significant difference (25% vs. 91.6%) in the onset of diabetes among Lisofylline treated mice compared to placebo mice. Reduction of inflammatory cytokines IFN-? And TNF-? levels correlated with reduction in ss cell apoptosis. [Yang et.al, 2003] Recent study by Lipsett et.al (2007) has shown that Islet Neogenesis-Associated Protein (INGAP) is useful as a pancreatic regeneration agent. Successful tests in mice and regeneration of cultured human pancreatic cells have encouraged the researchers to seriously consider INGAP as an effective agent for improving insulin synthesis. [Lipsett et.al, (2007)]
A recent Cornell University study focused on an entirely different approach to diabetes management. The researchers examined the possibility of recombinant Commensal bacteria engineered to secrete insulinotropic proteins GLP-1 and PDX-1. The study revealed that the GLP-1 and PDX-1 proteins secreted in the gut bacteria were able to stimulate the intestinal epithelial cells to secrete insulin in response to glucose. This method has the added advantage that commensal bacteria are well tolerated and therefore cause no adverse reactions. [Faping Duan]
Conclusion
The pandemic nature of diabetes and the increasing number of diabetics necessitates a sense of urgency in the prevention, control and management of this chronic condition. As an autoimmune and polygenic disorder, diabetes presents a complex challenge to the health care sector worldwide. The ever-increasing diabetic population places a huge strain on the available insulin resources and has forced researchers to consider new biotechnological therapeutics in the treatment of the condition. While Insulin therapy and appropriate Immunosuppressive treatment are the frontline therapy in the effective management of Type 1 diabetes, the growing field of pharmacogetics in diabetes promises to offer novel and effective therapies which would regenerate the bodies natural insulin production system. With our increasing understanding of the genetic factors of diabetes, genetic therapy promises to be vital in the battle against the condition. Recombinant...
There is little doubt that the biotechnology way would be central in the effective management of this chronic condition.
Bibliography
1) George S. Eisenbarth, (2007) 'Update in Type 1 Diabetes', The Journal of Clinical Endocrinology & Metabolism Vol. 92, No.7. http://jcem.endojournals.org/cgi/content/full/92/7/2403
2) McGill University, 'Deficient Regulators in the Immune System Responsible for Type 1 Diabetes', Updated 25 Jan 2008, Available at, http://www.sciencecentric.com/news/article.php?q=08012539
3) Kent SC, Chen Y, & Bregoli L. et.al (2005) 'Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope'. Nature 435:224 -- 228
4) Mathieu C, Gysemans C. et.al (Jul 2005), 'Vitamin D and Diabetes', Diabetologia. 48(7):1247-57
5) WHO, 'Genetics and Diabetes', Accessed 24th Jun 2009, Available at, http://www.who.int/genomics/about/Diabetis-fin.pdf
6) WHO, 'Diabetes Fact sheet', Accessed 24th Jun 2009, Available at, http://www.who.int/mediacentre/factsheets/fs312/en/index.html
7) Lipsett Mark & Hanley Stephen et.al (2007), 'The role of islet Neogenesis-Associated protein (INGAP) in islet neogenesis', Cell biochemistry and biophysics, 2007, vol. 48, pp. 127-137
8) Yang, Zandong; Chen, Meng & Fialkow, Lawrence B. et.al (2003), 'The Novel Anti-inflammatory Compound, Lisofylline, Prevents Diabetes in Multiple Low-Dose Streptozotocin-Treated Mice', Pancreas, May 2003 - Volume 26 - Issue 4 - pp e99-e104
9) Faping Duan, Katherine L. Curtis, and John C. March, (December 2008) 'Secretion of Insulinotropic Proteins by Commensal Bacteria: Rewiring the Gut To Treat Diabetes', Applied and Environmental Microbiology, p. 7437-7438, Vol. 74, No. 23, [Online] Available, http://aem.asm.org/cgi/content/full/74/23/7437#R14
10) ADA, 'All about Diabetes', Accessed 24th Jun 2009, Available at, http://www.diabetes.org/about-diabetes.jsp
11) Katarina Hjelm et.al, (Mar 2003) 'Preparing Nurses to Face the Pandemic of Diabetes Mellitus; A Literature review', Journal of Advanced Nursing, Vol 41 Issue 5-Page 424
Bibliography
1) George S. Eisenbarth, (2007) 'Update in Type 1 Diabetes', The Journal of Clinical Endocrinology & Metabolism Vol. 92, No.7. http://jcem.endojournals.org/cgi/content/full/92/7/2403
2) McGill University, 'Deficient Regulators in the Immune System Responsible for Type 1 Diabetes', Updated 25 Jan 2008, Available at, http://www.sciencecentric.com/news/article.php?q=08012539
3) Kent SC, Chen Y, & Bregoli L. et.al (2005) 'Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope'. Nature 435:224 -- 228
4) Mathieu C, Gysemans C. et.al (Jul 2005), 'Vitamin D and Diabetes', Diabetologia. 48(7):1247-57
5) WHO, 'Genetics and Diabetes', Accessed 24th Jun 2009, Available at, http://www.who.int/genomics/about/Diabetis-fin.pdf
6) WHO, 'Diabetes Fact sheet', Accessed 24th Jun 2009, Available at, http://www.who.int/mediacentre/factsheets/fs312/en/index.html
9) Faping Duan, Katherine L. Curtis, and John C. March, (December 2008) 'Secretion of Insulinotropic Proteins by Commensal Bacteria: Rewiring the Gut To Treat Diabetes', Applied and Environmental Microbiology, p. 7437-7438, Vol. 74, No. 23, [Online] Available, http://aem.asm.org/cgi/content/full/74/23/7437#R14
10) ADA, 'All about Diabetes', Accessed 24th Jun 2009, Available at, http://www.diabetes.org/about-diabetes.jsp
Diabetes Management Diabetes mellitus is one of the non-communicable diseases that have continued to be in the forefront of public health challenges. Diabetes occurs when the body system is unable to produce sufficient insulin. Typically, insulin is a hormone secreted from the beta cell within the pancreases that regulates the blood sugar as well as assisting in conversion of glucose into energy. Diabetes occurs when there is high level of glucose
The high levels of blood glucose lead to the production of insulin therefore patients have excessive production of insulin. There is insulin resistance and hence body cells do not respond in an appropriate way in the presence of insulin (Mealey, 2010). The main difference between diabetes insipidus, and diabetes mellitus, is that in diabetes mellitus insulin resistance is referred to being "post-receptor." This implies that the problem lies with the
In Vallejo, however, because of the Hispanic ethnic background of much of the population, there is a profound, healthy, and deeply culturally ingrained appreciation for the sport of baseball. Thus, to foster this interest, expanding the Little League and offering financial support to existing community organizations is one of the physical activity components of the action plan designed for the area ("Children and Weight: Taking Action in the Vallejo Community,"
One must remember that poor coping skills would render the patient more susceptible to diabetes related complications, and also have an adverse impact on self-care. It is in order to counter this that individuals and their families are advised to undergo regular screening procedures, so that psychological and related problems could be handled at the very outset, instead of allowing them to fester, thereby putting the patient at greater
This is nothing to be ashamed of, it is as much as part of you as your eye color -- it just needs to be managed. What are some risky behaviors teens often forget might aggrevate their diabetes? A) Alcohol, B) Marijuana, C) Drugs such as cocaine, meth, or heroine, D) Tatooing and body piercing, E) all the above. Answer -- D, all the above. Substances might make you do something you
These drugs help to control blood glucose levels and have fewer side effects and are not likely to interact of be contraindicated with other medication Kasper & Giovannucci, 2006() 6. To be able monitor the disease on their own It is crucial for the client to be able to track their condition. Therefore, they must be trained on how to monitor their blood glucose levels to be able to discover potential