Ground Breaking And Innovative Instances Research Proposal

Length: 6 pages Sources: 5 Subject: Disease Type: Research Proposal Paper: #71397766 Related Topics: Alzheimers, Prostate Cancer, Ovarian Cancer, Human Brain
Excerpt from Research Proposal :

The exchange of the defective gene could be brought about by a process called homologous recombination. One of the first gene therapy experiments, though well intentioned, caused the death of the patient. Researchers at the University of Pennsylvania introduced a normal gene into a boy's body by using the rhino virus as a carrier. The body's immune system attacked this as a pathogen. This led to eventual organ failure and death. Gene therapy projects all over the world were largely abandoned. But more recently, gene therapy is beginning to make a comeback. (ORNL, 2009)

Gene therapy has been tested in the treatment of Alzheimer's disease. This is not a treatment that targets amyloid beta proteins or the tangles, but protects the brain cells from destruction. The regenerative properties of skin cells (stem cells) have been used to prevent the brain cells from "withering" away. Positron Emission Tomography (PET) scans reveal greater brain activity because it reduces the cell death. The improvement rates are up to 50%, which gives hope to the researchers.

Researcher Gary Small and his team have attempted to work on methodologies to prevent the cause of Alzheimer's disease. This involves scanning people within a certain age groups. The scans are designed to reveal both the over expression of amyloid-beta proteins as well the existence of neurofibrillary tangles. These scans will be useful in identifying patients who are susceptible to Alzheimer's disease. (Elements4health, 2009)

One of the common features of this article is that large scale later phase human trials have not been run on any of the treatment modalities. It can be concluded therefore that these treatments have potential but have not yet been proven. Indeed, most local news on television has a health segment, where possible therapies for common ailments are touted. But there is no follow up about whether the research has borne fruits. The Pharma lobby was instrumental in getting Congress to allow the advertisement of pharmaceutical products on television. All advertisements follow a similar pattern. After the description...

...

The advertisement, to protect the company from lawsuits, also lists all the possible side effects from taking the product. Anne Underwood, much like other mass media outlets, creates an impression that a treatment for Alzheimer's is imminent. Underwood sets the stage for holding the readers' interest in her article by showing statistics of how many of the older populace were suffering from Alzheimer's and projects that these numbers are likely to go higher within the next decade. Certainly a reader of Newsweek, especially a senior citizen or a family member of one suffering from Alzheimer's disease would be filled with hope that a cure is just around the corner. There are unfortunately, no guarantees that these hopes would be realized.

References

http://www.alzforum.org/drg/drc/detail.asp?id=84Alzforum. (2009). Retrieved April 18, 2009, from BBC. (2003). Alzheimer's vaccine 'promising'. Retrieved April 18, 2009, from Alzheimer's vaccine 'promising'

ChemoCare. (2005). Taxol. Retrieved April 18, 2009, from http://www.chemocare.com/bio/taxol.asp

Elements4health. (2009). PET Scans Reveal Plaques and Tangles In Alzheimer's Retrieved April 18, 2009, from http://www.elements4health.com/pet-scans-reveal-plaques-and-tangles-in-alzheimers.html

Feng, J.A., Crasto, C.J., & Matsumoto, Y. (1998). Deoxyribose phosphate excision by the N-terminal domain of the polymerase beta: the mechanism revisited. Biochemistry, 37(27), 9605-9611.

ORNL. (2009). Gene Therapy. Retrieved April 18, 2009, from http://www.ornl.gov/sci/techresources/Human_Genome/medicine/genetherapy.shtml

Parker, R. (2004, Parker). Alzheimer's vaccine 'promising'. Retrieved April 18, 2009, from http://www.futurepundit.com/archives/cat_brain_alzheimers_disease.html

Richon, A.B., & Young, S.S. (2009). An Introduction to QSAR Methodology. Retrieved April 18, 2009, from http://www.netsci.org/Science/Compchem/feature19.html

Underwood, A. (2005, June 10, 2005). 7 Ways to Save the Brain. Newsweek.

Uryu, K., Chen, X.H., Martinez, D., Browne, K.D., Johnson, V.E., Graham, D.I., et al. (2007). Multiple proteins implicated in neurodegenerative diseases accumulate in axons after brain trauma in humans. Exp Neurol, 208(2), 185-192.

Voyager. (2009). Leuprolide Acetate Stabilizes Cognitive And Functional Decline In Women With Alzheimer's Disease, Study Shows. Retrieved April 18, 2009, from http://www.medicalnewstoday.com/articles/43507.php

Walsh, D.M., Tseng, B.P., Rydel, R.E., Podlisny, M.B., & Selkoe, D.J. (2000). The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain. Biochemistry, 39(35), 10831-10839.

Sources Used in Documents:

References

http://www.alzforum.org/drg/drc/detail.asp?id=84Alzforum. (2009). Retrieved April 18, 2009, from BBC. (2003). Alzheimer's vaccine 'promising'. Retrieved April 18, 2009, from Alzheimer's vaccine 'promising'

ChemoCare. (2005). Taxol. Retrieved April 18, 2009, from http://www.chemocare.com/bio/taxol.asp

Elements4health. (2009). PET Scans Reveal Plaques and Tangles In Alzheimer's Retrieved April 18, 2009, from http://www.elements4health.com/pet-scans-reveal-plaques-and-tangles-in-alzheimers.html

Feng, J.A., Crasto, C.J., & Matsumoto, Y. (1998). Deoxyribose phosphate excision by the N-terminal domain of the polymerase beta: the mechanism revisited. Biochemistry, 37(27), 9605-9611.


Cite this Document:

"Ground Breaking And Innovative Instances" (2009, April 20) Retrieved August 4, 2021, from
https://www.paperdue.com/essay/ground-breaking-and-innovative-instances-22684

"Ground Breaking And Innovative Instances" 20 April 2009. Web.4 August. 2021. <
https://www.paperdue.com/essay/ground-breaking-and-innovative-instances-22684>

"Ground Breaking And Innovative Instances", 20 April 2009, Accessed.4 August. 2021,
https://www.paperdue.com/essay/ground-breaking-and-innovative-instances-22684

Related Documents
Innovative Kind of High Temperature
Words: 2079 Length: 6 Pages Topic: Energy Paper #: 8515652

At functioning temperatures higher than 1000°C, the most imperative heat-transfer instrument becomes emission instead of conduction and convection, which are the more noteworthy heat-transfer devices at lower temperatures. The outsized pores in the cement IFB are wasteful at decreasing energy reassignment at the infrared wavelengths concerned, so this kind of IFB shows a superior thermal conductivity in comparison with the cast. On the other hand, the microporous arrangement of the

Apple Corporation SWOT Analysis Apple Inc. Is
Words: 1635 Length: 6 Pages Topic: Education - Computers Paper #: 5495092

Apple Corporation SWOT analysis Apple Inc. is one of the well-known and recognized enterprises by not only the business community but populace from all over the world are cognizant about this corporation. It started off its business from the decade of 1970 that has been involved in the designing, manufacturing and offering its consumers with a wide range of innovative and technologically refined products like computers, software, music players and its

Japanese-American Biopharmaceutical Industry in the 21st Century
Words: 20340 Length: 60 Pages Topic: Medicine Paper #: 56745338

Japanese-American Biopharmaceutical Industry in the 21st Century Optimizing Ethical Drug Availability Between These Two Pharmaceutical Superpowers" The Japanese-American biopharmaceutical industry represents an ongoing international effort between the two top pharmaceutical markets in the world. These two economic powers provide consumers with a majority share of all pharmaceuticals produced in the world. However, a number of pharmaceutical products that are currently available to U.S. residents are unavailable to Japanese consumers. From a humanitarian perspective, this

Health Care Population
Words: 1656 Length: 5 Pages Topic: Engineering Paper #: 14151488

2015 will be the year of innovation for UAE which will involve the Traditional methods of innovation system analysis that will mostly put the focus on describing the structure of an innovation system. This is being done because in the past it has been argued that it has proved to be inadequate for understanding the factors and procedures that drive and bear innovation (Kan, 2015). In many studies, the

How Environment Influences Business
Words: 6102 Length: 20 Pages Topic: Business Paper #: 84890856

Effect of External and Internal Environment Introduction Organizations have both an internal and external environment. To begin with, the forces or circumstances within the borderline of the organization are the components of the internal environment. Notably, the internal environment comprises for the most part of the owners, employees, board of directors, stakeholders, and the corporate culture. On the other hand, factors that are extrinsic to the organization are the components of the

Nestle Company Nestle's Long History
Words: 13087 Length: 50 Pages Topic: Business Paper #: 23326176

Governments in these developing countries also may have issues with foreign companies expanding within their borders. Lastly, establishing local suppliers, and the infrastructure required for these suppliers, may be a challenge, especially for those they develop from the ground up. Strategic Posture: Nestle's mission statement is simple. "Good Food, Good Life'. That mission is to provide consumers with the best tasting, most nutritious choices in a wide range of food and beverage