Heart Disease Essay

Length: 2 pages Sources: 1 Subject: Physiology Type: Essay Paper: #46213368 Related Topics: Heart Disease, Exercise Physiology, Cardiovascular Disease, Cholesterol
Excerpt from Essay :

Atherosclerosis and the various complications associated with this disease, especially towards its final stages, may causes disability and death within Western societies. Although advancement of atherosclerosis is a slow process, beginning in childhood, remaining asymptomatic for several decades, complication like myocardial infarction, peripheral ischemia, or stroke happening later on in life. Some recognized risk factors towards the development of the illness include diabetes, hypertension, obesity, dyslipidaemia, smoking, sedentary lifestyle, and ageing. Several studies suggest heritability of coronary atherosclerosis, established through fatal cardiac episodes between 38 and 57%.

Furthermore, epidemiology studies also correlate a positive


Such occurrences derived from genetics include lipid profile as well as genes related to obesity. Development of these molecular biology methods promotes effective identification of these "candidate genes" through use of high-throughput technologies like genome-wide scans. An article explains the connection between the illness and heredity.

A family history of atherosclerosis is independently associated with an increased incidence of cardiovascular events. The genetic factors underlying the importance of inheritance in atherosclerosis are starting to be understood. Genetic variation, such as mutations or common polymorphisms has been shown to be involved in modulation of a range of risk factors, such as plasma lipoprotein levels, inflammation and vascular calcification (Biros, Karan & Golledge, 2008, p. 29).

Some links such as APOE (gene), which is a main protein of the lipid-transportation system, regulates serum cholesterol as well as participating in development of high-density lipoprotein or HDL particles. Furthermore, hepatic parenchymal cells facilitate construction of all outlying APOE. The body rapidly removes APOE-containing particles from circulation through binding to LDLR or LDLR-like protein receptor mediating endocytosis within the liver. The body maps APOE to chromosome 19 at 19q13.2. From there it is linked to apolipoprotein C1 and C2.

APOE is a clear link between the disease and genes. One can produce within the body, the conditions to promote or accelerate this kind of disease. Sure environmental conditions outside the body like poor eating habits and a sedentary lifestyle will contribute; however, genetic predisposition plays a part. When the body cannot remove excess cholesterol as efficiently as someone who does not possess the defective genes to produce such a result, a person with these genes will experience higher levels of blood cholesterol. Even if a person eats healthy and maintains a proper weight, the excess cholesterol may lead or add…

Sources Used in Documents:


Biros, E., Karan, M., & Golledge, J. (2008). Genetic Variation and Atherosclerosis. CG, 9(1), 29-42. doi:10.2174/138920208783884856

Cite this Document:

"Heart Disease" (2015, February 27) Retrieved January 17, 2022, from

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"Heart Disease", 27 February 2015, Accessed.17 January. 2022,

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