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Atherosclerosis and the various complications associated with this disease, especially towards its final stages, may causes disability and death within Western societies. Although advancement of atherosclerosis is a slow process, beginning in childhood, remaining asymptomatic for several decades, complication like myocardial infarction, peripheral ischemia, or stroke happening later on in life. Some recognized risk factors towards the development of the illness include diabetes, hypertension, obesity, dyslipidaemia, smoking, sedentary lifestyle, and ageing. Several studies suggest heritability of coronary atherosclerosis, established through fatal cardiac episodes between 38 and 57%.
Furthermore, epidemiology studies also correlate a positive family history is independently related with the occurrence of cardiovascular events. Such occurrences derived from genetics include lipid profile as well as genes related to obesity. Development of these molecular biology methods promotes effective identification of these "candidate genes" through use of high-throughput technologies like genome-wide scans. An article explains the connection between the illness and heredity.
A family history of atherosclerosis is independently associated with an increased incidence of cardiovascular events. The genetic factors underlying the importance of inheritance in atherosclerosis are starting to be understood. Genetic variation, such as...
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Some links such as APOE (gene), which is a main protein of the lipid-transportation system, regulates serum cholesterol as well as participating in development of high-density lipoprotein or HDL particles. Furthermore, hepatic parenchymal cells facilitate construction of all outlying APOE. The body rapidly removes APOE-containing particles from circulation through binding to LDLR or LDLR-like protein receptor mediating endocytosis within the liver. The body maps APOE to chromosome 19 at 19q13.2. From there it is linked to apolipoprotein C1 and C2.
APOE is a clear link between the disease and genes. One can produce within the body, the conditions to promote or accelerate this kind of disease. Sure environmental conditions outside the body like poor eating habits and a sedentary lifestyle will contribute; however, genetic predisposition plays a part. When the body cannot remove excess cholesterol as efficiently as someone who does not possess the defective genes to produce such a result, a person with these genes will experience higher levels of blood cholesterol. Even if a person eats healthy and maintains a proper weight, the excess cholesterol may lead or add to the increased risk…
References
Biros, E., Karan, M., & Golledge, J. (2008). Genetic Variation and Atherosclerosis. CG, 9(1), 29-42. doi:10.2174/138920208783884856
Heart Disease and the Elderly The objective of this work in writing is to examine how heart disease takes a toll elderly. Toward this end, this work will conduct a review of literature that examines the toll that heart disease takes on the elderly population. Approximately 18 million people or 7% of all individuals in the United States have heart disease. Heart disease affects older people more significantly as the elderly are
For example, some prescription drugs have been shown to increase risk for heart disease (Fries, nd). In particular, non-steroidal anti-inflammatory drugs (NSAIDs), which are commonly prescribed for relieving the pain associated with arthritis, have been shown to cause heart-related side effects (Fries, nd). Unfortunately, patients who suffer from chronic pain sometimes need to choose between increasing their risk for heart disease and coping with severe chronic pain. Interestingly, though,
Heart Disease (CAD: Coronary Artery Disease) Online web site HeartPoint defines Coronary Artery Disease as Coronary artery disease generally refers to the buildup of cholesterol in the inside layers of the arteries. As shown here, this will slowly narrow the flow of blood through the vessel, and the muscle it supplies will not get enough blood. The plaque weakens the wall. As shown in the lower artery, a crack may develop
The estimated age-adjusted prevalence of angina in women age 20 and older were 3.5% for non-Hispanic white women, 4.7% for non-Hispanic black women and 2.2% for Mexican-American women. Rates for men in these three groups were 4.5, 3.1 and 2.4%, respectively. Among American adults age 20 and older, the estimated age-adjusted prevalence of coronary heart disease for non-Hispanic whites is 8.9% for men and 5.4% for women; for non-Hispanic
Macabasco-O'Connell et.al say that the stress levels for women in this group is oftentimes higher than non-minority women in higher socioeconomic groups. The high amount of stress that these women experience is usually accompanied with depression and studies have shown that depression can also lead to a greater risk of heart disease (2, 3). Because many women from lower socio-economic statuses are uninsured or underinsured, they run the risk
In fact, dietary lipids, serum cholesterol, and sodium are linked directly with heart disease. Diets high in sodium lead to hypertension, or high blood pressure, which is also linked with the malady. Thus, a decrease in the amount of saturated fat and cholesterol for all people, as well as limiting the amounts of total fat, processed sugars, and calories for those who are overweight, is recommended for preventing the