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Chugh, G., Pokkunuri, I., Asghar, M. (2013). Renal dopamine and angiotensin II
receptor signaling in age-related hypertension. Am J Physiol Renal Phyiol, 304: F1-F7.
The researchers discuss the roles of dopamine and angiotensin II in the kidneys in regulating blood pressure. The study is focused on recent analysis of the way in which these renal receptors signal to one another and how these signals are factored into the process of the body's aging. The study examines the history of research on the subject of the rennin-angiotension system and the renal dopaminergic system and explores new findings related to the process of blood pressure regulation by posing questions, such as, "Do tissue factors, especially dopamine, change during renal aging?" (p. F2). The study discusses the ramifications of targeting specific receptors with agonists and antagonists in order to thwart renal aging and stem the effects of this process among geriatrics.
Chugh, G., Lokhandwala, M., Asghar, M. (2012). Altered functioning of both renal dopamine D1 and Angiotensin II type 1 receptors causes hypertension in old rats. Hypertension, 59: 1029-1036.
This study identifies the cause of hypertension in aged rats as being dopamine D1 and angiotensin II type 1 receptors. This study is complimentary to the other study led by Chugh (2013) and...
The findings of this study reveal extensive analysis of a number of receptors, proteins, controls, and their relation to increases in blood pressure, and the underlying factor of an "increase in oxidative stress" which changes the DIR and ATR renal receptors pivotal in the regulation of the blood pressure (p. 1035).
Wiggins, J. (2011). Why do our kidneys get old? Nephron Exp Nephrology, 119(suppl
1): e1-e5.
Wiggins's study analyzes the fact that kidneys must deal with the aging of the body in the same as everything else and that stress affects this process, as both salt and acid contents become less easy to process. Wiggins explores the ideas connected to the aging downturn in effectiveness of the kidneys to process the body's contents and what can be learned in terms of renal receptors. Wiggins essentially dissects the biological function of the kidneys to provide the reader with a detailed description of how the process works, how the cells interact, and the roles that are played. In examining these functions, the researcher also explores possible explanations for how the kidneys are affected by aging: for example, the researcher highlights the…
References
Chugh, G., Lokhandwala, M., Asghar, M. (2012). Altered functioning of both renal dopamine D1 and Angiotensin II type 1 receptors causes hypertension in old rats. Hypertension, 59: 1029-1036.
Chugh, G., Pokkunuri, I., Asghar, M. (2013). Renal dopamine and angiotensin II
receptor signaling in age-related hypertension. Am J Physiol Renal Phyiol, 304: F1-F7.
Montasser, M. et al. (2011). Determinants of blood pressure response to low-salt intake in a healthy adult population. Journal of Clinical Hypertension, 13(11): 795-799.
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