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Refining other techniques is laudable and important, but is not the domain of the proposed research. In addition, the mixed methods use of both mass spectrometry and bioinformatics methodologies is logically called fro due to the volume of data the mass spectrometry is expected to generate and the time consuming nature of any other mode of analysis save those available through specialized bioinformatics programs (Kuamr & Mann, 2009).
Conclusion & Mann, M. (2003). Mass spectrometry-based proteomics. Nature 422: 198-207.
The selection of the model bacterial strain and of the previously validated antibiotic agent will be important considerations for this research, and will have a direct impact on the applicability of the results in other areas of research. Selection should be made on a basis of practicality not only in the ability to carry out the research, but also in light of how the findings can and might actually be applied. There are no real ethical implications that need to be considered in this research, however the need for more effective antibiotics does place an ethical constraint of increased accuracy and reliability on the research.
References
Aldred, S., Grant, M. & Griffiths, H. (2004). The use of proteomics for the assessment of clinical samples in research. Clinical Biochemistry 37(11): 943-52.
Freiberg, C., Brotz-Oesterhelt, H. & Labischinski, H. (2004). The impact of transcriptome and proteome analyses on antibiotic drug discovery. Current Opinion in Microbiology 7(5): 451-9.
Kuiper, H., Kok, E. & Engel, K. (2003). Exploitation of molecular profiling techniques for GM food safety assessment. Current Opinion in Biotechnology 14(2): 238-43.
Kumar, C. & Mann, M. (2009). Bioinformatics analysis of mass spectrometry-based proteomics data sets. FES Letters 583(11): 1703-12.
Saeys, Y., Inza, I. & Larranaga, P. (2007). A review of feature selection techniques in bioinformatics. Bioinformatics 23(19): 2507-17.
Whiteaker, J., Zhang, H., Eng, J., Fang, R…. & Paulovich, a. (2007). Head-to-Head Comparison of Serum Fractionation Techniques. Journal of…
References
Aebersold, R. & Mann, M. (2003). Mass spectrometry-based proteomics. Nature 422: 198-207.
Aldred, S., Grant, M. & Griffiths, H. (2004). The use of proteomics for the assessment of clinical samples in research. Clinical Biochemistry 37(11): 943-52.
Freiberg, C., Brotz-Oesterhelt, H. & Labischinski, H. (2004). The impact of transcriptome and proteome analyses on antibiotic drug discovery. Current Opinion in Microbiology 7(5): 451-9.
Kuiper, H., Kok, E. & Engel, K. (2003). Exploitation of molecular profiling techniques for GM food safety assessment. Current Opinion in Biotechnology 14(2): 238-43.
BACTERIA Pseudomonas Bacteria This study concerns the Pseudomonas type bacterium strains that have, in recent years, become more of a concern for medical professionals. The primary issue is that several different types of the bacteria, especially pseudomonas aeruginosa, have been shown to have a resistance to many common antibiotics. Another issue with this genus is that it is a very common type of bacteria that naturally occurs in the soil, in plant
Bacteria? Many people believe that bacteria only cause disease and death. This is not technically true. While we have all suffered from some kind of an infection which we are told is caused some noxious form of bacteria, this is just a small part of what bacteria contribute to out lives. First, it would be well to add a bit of science to be clear about what bacteria are. Defined most
What are Bacteria and Viruses? The most palpable variance between bacteria and viruses is their size. Whereas both bacteria and viruses are too tiny to notice with the naked eye, most bacteria are about one micrometer in length and can be perceived with a good optical microscope. On the other hand, viruses are smaller than the wavelength of visible light, which implies that they can be solely perceived by using an
Bacteria Effect of date extract on different types of bacteria Taxonomy of date Kingdom: Plantae Division: Magnoliophyta Liliopsida Order: Arecales Family: Arecaceae Genus: Phoenix Species: Phoenix dactylifera Binomial mane: Phoenix dactylifera Linn (Bostoen 2005) Botanical Descriptions The date palm is known in technical terms by its botanical name Phoenix dactylifera. The properties and the composition of the date extract have been noted to have many beneficial effects in medicine as well as domestically. The following paper intends to shed light on the impact
One organism, Methicillin-resistant Staphylococcus aureus (MRSA), kills approximately 19,000 Americans annually, which is more than HIV / AIDS, Parkinson's disease, emphysema, and homicide combined (5). In the mid-1980s, the incidence of MRSA isolates was close to zero, and by 1998 the incidence of MRSA was approximately 70% in Japan, 40% in Belgium, 30% in the United Kingdom, and 28% in the United States (1). Every year, 2 million Americans
Psuedomonas aeruginosa: A nosocomial bacteria Challenges to healthcare Annotated Bibliography (1) Melaku, S., Gebre-Selassie, S., Damtie, M., and Alamrew, K. (2012) Hospital acquired infections among surgical, gynecology and obstetrics patients in Felege-Hiwot referral hospital, Bahir Dar, northwest Ethiopia. Ethiop Med 2012 -- Apr; 50(2): 135-44. Retrieved from PubMed. Melaku, Gebre-Selassie, Damtie, and Alamrew (2012) report a study with the objective of assessing the prevalence and risk factors of hospital-acquired infections and the antibiotic susceptibility