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Currently, osteoarthritis afflicts almost 1 out of 10 (9.6%) men and 2 out of 20 (18%) women aged 60 years and older (Woolf & Pfleger, 2003). As a result of increases in longevity, osteoarthritis is projected to become the fourth leading cause of disability by the year 2020 (Woolf & Pfleger, 2003). According to Brooks (2003), "Genetic factors determining the biochemical constituents of bone and cartilage may place individuals at an increased risk of osteoarthritis. Given the number of cell types in cartilage and bone, there is the potential for many genes to contribute to the predisposition to osteoarthritis" (p. 689). Genetic factors can also help protect people from being afflicted with osteoarthritis. For instance, Barazesh (2009) advises that, "Genes that make bones grow longer can form extra cartilage in joints, protecting them from the ravages of osteoarthritis" (p. 23).
By contrast, rheumatoid arthritis affects between 0.3-1.0% of the general population; however, the condition is more prevalent among women and in emerging nations (Woolf & Pfleger, 2003). In fact, about 2.5 times as many women are affected by rheumatoid...
In addition, the possibility for extra-articular manifestations with rheumatoid arthritis is thought to take place in genetically susceptible individuals (Rheumatoid arthritis, 2013).
References
Barazesh, S. (2009, May 9). The genetic dimension of height and health. Science News, 175(10),
22-25.
Brooks, P. (2003, September). Inflammation as an important feature of osteoarthritis. Bulletin of the World Health Organization, 81(9), 689-673.
Lee, D-H & Steffes, M. (2007, June). Positive associations of serum concentration of polychlorinated biphenyls or organochlorine pesticides with self-reported arthritis, especially rheumatoid type, in women. Environmental Health Perspectives, 115(6), 883-
Rheumatoid arthritis. (2013). Medscape. Retrieved from http://emedicine.medscape.com / article/331715-overview#aw2aab6b2b3.
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disorder that primarily affects the joints but can also have widespread systemic manifestations. The pathophysiology of RA involves an intricate interplay between genetic factors, environmental triggers, immune system dysregulation, and inflammatory pathways that lead to joint damage and systemic complications. Genetic susceptibility plays a significant role in the onset of RA. Although no single gene is responsible for the disease, certain genetic markers
Rheumatoid arthritis (RA) is a chronic, autoimmune disease that primarily affects the joints, leading to pain, swelling, stiffness, and joint destruction. The pathophysiology of RA involves a complex interplay of genetic, immunological, and environmental factors. Genetic Susceptibility: Genetic factors play a significant role in the development of RA. Specific genetic variants, particularly those within the human leukocyte antigen (HLA)-DRB1 locus, have been associated with an increased risk of the disease. HLA-DRB1 molecules
Arthritis is considered as one of the major health conditions affecting a significant portion of the United States population. Even though the condition currently affects approximately 50 million adults in the country, it is not primarily an adulthood health condition. There are numerous cases of children suffering from arthritis, which implies that this condition is not uncommon among children. As a result of the prevalence of arthritis among children and
Osteoarthritis Victims of Intimate Violence: Laci Peterson and Minh Dang Osteoarthritis refers to the form of arthritis affecting the joints of individuals, especially middle age and elderly members of the society (Walker, 2011). Osteoarthritis is known as 'OA' or wear and tear of the joints. Osteoarthritis is a joint disease or pathology affecting the entire joints, ligaments, linings of the joints, cartilage, and bones of the affected persons within the society. According
Muscular dystrophy and myasthenia gravis are complicated conditions. According to the research, muscular dystrophy is a "group of familial disorders that cause degeneration of skeletal muscle fibers" (Carroll, 2008, p 1633). Many researchers believe that the different types are each caused by different biochemical defects. For example, Duchenne Muscular Dystrophy is thought t be the result of a single gene defect "thought to be caused by a deletion of a