Physical Activity And Telomere Length In Early Essay

Length: 2 pages Sources: 2 Subject: Disease Type: Essay Paper: #89126500 Related Topics: Breast Cancer, Aging, Cancer, Dna
Excerpt from Essay :

Physical Activity and Telomere Length in Early Stage Breast Cancer Survivors

Journal article summary (paragraph format, double-spaced), which summarizes the article's content. Do not include your opinion about content of the article.

The journal article focuses on the relationship between human physical activity and telomere length in early stage breast cancer survivors. Telomere as the article illustrates is a biomarker for both cellular damage and aging within individuals with breast cancer. Evidence suggests that TL in those without breast cancer is impacted by a host of psychosocial and lifestyle factors, including physical activity.

The journal begins with a brief overview of Telomere and its implications for breast cancer survivors. Telomere is a repetitive nucleoprotein structures on the end of chromosomes with the main purposes of maintaining cellular stability. Telomere also protects cells from uncontrollable cellular division. The article note that cell division is generally good for the body as it helps with repair and replication, however, when conducted in an uncontrollable state, damage is done to the body. As cells divides the Telomere portion of the end of each chromosome shortens. Eventually, the telomere is completely consumed through cell division. Once the Telomere is consumed, the cell will...


Many premature signs of aging, disease and cancer have been linked to shortened Telomeres within cells.

The article studies the overall physical activities of patients and how this activity impacts Telomere length. Through study and observation, the researchers believe that longer Telomere's lead to healthier patients, with lower signs of aging, and less change of recurrence. The length of Telomere is particularly important as the researchers believe that cancer recurrence is likely to be dependent on a complex interplay between cancer and biological mechanisms within the body. The research team studied 392 postmenopausal women with stage I-III breast cancer at an outpatient oncology clinic. The clinic was located at the Abramson Cancer Center of the University of Pennsylvania. Telomere length and shortening was determined using fragment length analysis of genomic DNA isolated from certain blood cells.

The research found that women with stronger habits of physical activity had longer Telomere within their cells. The variance between those women within the sample that engaged in physical activity and those that didn't was roughly 78%. In addition, the study found that among participants, 17% of women did not engage in physical activity whatsoever. The results showed that these participants had shorter TL…

Sources Used in Documents:


1) Garland et al.: Physical activity and telomere length in early stage breast cancer survivors. Breast Cancer Research 2014 16:413.

2) Williams SC (January 2013). "No end in sight for telomerase-targeted cancer drugs." Nat Med. 19 (1): 6

Cite this Document:

"Physical Activity And Telomere Length In Early" (2014, November 16) Retrieved December 4, 2022, from

"Physical Activity And Telomere Length In Early" 16 November 2014. Web.4 December. 2022. <>

"Physical Activity And Telomere Length In Early", 16 November 2014, Accessed.4 December. 2022,

Related Documents
Biochemistry of Hnrna C. And
Words: 8906 Length: 24 Pages Topic: Disease Paper #: 4616042

123). In this study, Martinez-Contreras and her associates report the results of recent research that has provided additional evidence concerning the function of these proteins in precursor-messenger RNA (pre-mRNA) splicing (2007). The splicing repression can function in two discrete ways in heterogeneous nuclear RNP proteins; the first way is by antagonizing the recognition of splice sites directly and the second way is through interference with the binding of proteins that

Stem Cell Differentiation the Need to Restore
Words: 3613 Length: 10 Pages Topic: Disease Paper #: 42462808

Stem Cell Differentiation The need to restore the lives of the individuals calls for more of transplantation than that which is available. There are fewer organs, which can help in the transplantation process, which means that overdependence on the process makes it to be reliable. Further, the process may also end up endangering the life of the donator. Transplantation is the only available process that can for the individuals having kidney