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Many infectious bacteria are difficult to eliminate without causing harm to the host organism as well, such as several species of the genus Leishmania for which chemotherapy has long been the only effective treatment (Kumari et al. 2008). Proteomics has led to the development of other drugs that work to inhibit certain protein and protease production processes in the bacteria, leading to their eradication without the harsh and host-harming toxicity of chemotherapy (Kumari et al. 2008). Other forms of chemotherapy specifically targeting specific protease substances have also been developed through an application of proteomics, suggesting still more avenues for research and pharmaceutical development utilizing the chemical knowledge and awareness gained from the study of proteins (Heal et al. 2008). As the substrates of proteases are better understood, methods have been developed to target specific proteases or families of proteases, making specific...
2008).
Proteomics is still a developing and even an expanding area of biomedical research. As understandings continue to become more refined, the efficacy of the drugs developed through proteomic endeavors will also continue to improve. This in turn leads to a better overall understanding of disease and wellness.
References
Heal, W.; Wickramasinghe, S. & Tate, W. (2008). "Activity-Based Chemical Proteomics: Profiling Proteases as Drug Targets." Current drug discovery technologies 5(3), pp. 200-12.
Kumari, S.; Kumar, A.; Samant, M.; Singh, N. & Dube, A. (2008). "Discovery of Novel Vaccine Candidates and Drug Targets Against Visceral Leishmaniasis Using Proteomics and Transcriptomics." Current drug targets 9(11), pp. 938-47.
Golde, T. & Kukar, T. (2009). "Avoiding Unintended Toxicity." Science 324(5927), pp. 603-4.
The success was remarkable, according to the researchers: Even muscles that had already lost half of its mass, recovered visible. (Leppanen et al. p5549-65) At the same time, the mice survived for several weeks longer than their untreated counterparts and also developed a healthy appetite again. (Mantovani, p296) The new study is therefore interesting in two respects: First, it demonstrates that the muscle loss at least in animal models in
Mitochondrial Diseases A gene is basically a one dimension sequence of nucleotides that signals for the production of a protein. (Reynaud, 2010) The protein itself is merely a sequence of amino acids arranged in a specific manner. The sequence of the gene is linear and so is the sequence of the protein. DNA, which is a common term heard now and then is merely a collective term for all the genes
production/income and so on. Some companies also include quality assessments as part of their analysis of department efficiencies. 5.Explain the role of the budget in the business control cycle. Budgets can be used to help a firm meet goals and objectives. The business control cycle consists of four steps. The first is setting the standard, that is, creating the budget. The next is recording the performance of the company's departments. Third,
Governments in these developing countries also may have issues with foreign companies expanding within their borders. Lastly, establishing local suppliers, and the infrastructure required for these suppliers, may be a challenge, especially for those they develop from the ground up. Strategic Posture: Nestle's mission statement is simple. "Good Food, Good Life'. That mission is to provide consumers with the best tasting, most nutritious choices in a wide range of food and beverage
Protection and preservation of the environment through increased yields and reduced use of chemical pesticides and herbicides. This is because genetically modified foods grow at a faster rate and in bigger quantities which means less forest land is cleared for agriculture and the natural habitats and biodiversity is preserved. The crops are also made pest and disease resistant which means that less pesticides and herbicides are used which could pollute
Refining other techniques is laudable and important, but is not the domain of the proposed research. In addition, the mixed methods use of both mass spectrometry and bioinformatics methodologies is logically called fro due to the volume of data the mass spectrometry is expected to generate and the time consuming nature of any other mode of analysis save those available through specialized bioinformatics programs (Kuamr & Mann, 2009). Conclusion The selection