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The disease is prevalent across some parts of Africa, the Middle East and India, which is due to the way in which the heterozygous form of the condition offers carriers a degree of protection against malaria, which is present in these areas. As a result, there is also a significant incidence of the disease in African-Americans, as a direct result of their African heritage, which means that the condition is significantly important for practitioners across the U.S. To understand.
References
Chowning, J.T. (2000) Sickle cell anemia and genetics: Background information. Washington State University Website. Retrieved on June 18, 2007, at http://genetics-education-partnership.mbt.washington.edu/.
Frenette, P.S. And Atweh, G.F. (2007) Sickle cell disease: Old discoveries,...
Journal of Clinical Investigation, 117, 850-858.
Ingram, V.M. (2004) Sickle-cell anemia hemoglobin: The molecular biology of the first "molecular disease" - the crucial importance of serendipity. Genetics, 167, 1-7.
Nagel, R.L. (2005) Sickle Cell Anaemia. Encyclopedia of Life Sciences, John Wiley and Sons. Retrieved June 18, 2007, from:
Steinberg, M.H. (2005) Sickle cell disease as a multifactorial condition. Encyclopedia of Life Sciences, John Wiley and Sons. Retrieved June 18, 2007, from:
Weatherall, D.J. (1997) ABC of clinical haematology: The hereditary anaemias. BMJ, 314, 492.
Appendix 1
Map to show the regions of the world in which the sickle cell gene is most commonly found.…
References
Chowning, J.T. (2000) Sickle cell anemia and genetics: Background information. Washington State University Website. Retrieved on June 18, 2007, at http://genetics-education-partnership.mbt.washington.edu/.
Frenette, P.S. And Atweh, G.F. (2007) Sickle cell disease: Old discoveries, new concepts and future promises. Journal of Clinical Investigation, 117, 850-858.
Ingram, V.M. (2004) Sickle-cell anemia hemoglobin: The molecular biology of the first "molecular disease" - the crucial importance of serendipity. Genetics, 167, 1-7.
Nagel, R.L. (2005) Sickle Cell Anaemia. Encyclopedia of Life Sciences, John Wiley and Sons. Retrieved June 18, 2007, from:
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