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H1 will essentially be ascertained following these tests.
Does iPS treatment rescue the motor and cognitive deficits associated with Angelman Syndrome: Data will be gathered from testing the treated mice in scientifically recognized tests of cognitive ability in a mouse model. This project proposes using the water maze test, the electric shock test, and the submerged platform test. H2 will effectively be answered using the data gleaned from these tests. (2008). The Angelman syndrome ubiquitin ligase localizes to the synapse and nucleus, and maternal deficiency results in abnormal dendritic spine morphology. Human Molecular Genetics, 111-118.
4. Conclusion
4.1. Potential Therapeutic and Other Considerations
The potential of using iPS treatment to rescue/alleviate the severe motor and cognitive deficits witnessed in Angelman Syndrome is theoretically viable. Reliable mouse models of AS exist with which to run the tests. The technology needed to tease iPS stem cells into fully functioning brain cells that express the UBE3A gene product is available and viable to conduct in a controlled setting. Therefore, the proposal as set forth is a logical one which addresses an urgent need in an uncharted territory -- treating imprinted neurological disorders using iPS treatment. If successful, the potential to treat not only other imprinted neurological disorders (Rett Syndrome, Prader Willi Syndrome) but to also treat other neurological disorders that share similar dysfunctional brain pathway etiologies, is immense. If the hypotheses in the proposal are proven, the door to researching viable and cutting-edge treatments for neurological disorders harkens to the researchers. Devastating disorders that cost immeasurable amounts of human suffering and untold millions of dollars in health care and long-term care, could be cured. A novel therapeutic that bypasses the ethical, political, and social backlash associated with stem cell research, could potentially change the course of mankind.
Bibliography
Abuhatzira, L., Shemer, R., & Razin, A. (2009). MeCP2 involvement in the regulation of neuronal alpha-tubulin production. Human Molecular Genetics, 1415-1423.
Condic, M.L., & Rao, M. (2008). Regulatory Issues for Personalized Pluripotent Cells. Stem Cells, 2753-2758.
Dobkin, B. (2007). Behavioral, temporal, and spatial targets for cellular transplants as adjuncts to rehabilitation for stroke. Stroke, 832-839.
Fischback, G., & Fischback, R. (2004). Stem cells: science, policy, and ethics. Journal of Clinical Investigation, 1364-1370.
Galanopoulou, A. (2010). Mutations affecting GABAergic signaling in seizures and epilepsy. European Journal of Physiology .
Heck, D., Zhao, Y., Snigdha, R., & LeDoux, M.S. (2008). Analysis of Cerebellar Function in Ube3a Deficient Mice Reveals Novel Genotype Specific Behaviors. Human Molecular Genetics .
Landers, M., Calciano, M.A., Colosi, D., Wagstaff, J., Glatt-Deeley, H., & Lalande, M. (2005). Maternal disruption of Ube3a leads to increased expression of Ube3a-ATS in trans. Nucleic Acids Research, 3976-3984.
MacDonald, B., Cockerell, O., & Sander, J. (2000). The incidence and lifetime prevalence of neurological disorders in a prospective community-based study in the UK. Brain, 665-676.
MB, P., K, B.-N., LK, H., & K., W. (1995). Clinical, cytogenetic, and molecular diagnosis of Angelman syndrome: estimated prevalence rate in a Danish county. American Journal of Medical Genetics, 261-262.
Mimeault, M., Hauke, R., & Batra, S. (2007). Stem Cells: A Revolution in Therapeutics -- Recent Advances in Stem Cell Biology and Their Therapeutic Applications in Regenerative Medicine and Cancer Therapies State of the Art. Clinical Pharmacology and Therapeutics, 252-264.
Rossi, F., & Cattaneo, E. (401-409). Neural stem cell therapy for neurological diseases: dreams and reality. Nature Reviews Neuroscience, 2002.
Stadtfeld, M., Nagaya, M., Utikal, J., Weir, G., & Hochedlinger, K. (2008). Induced pluripotent stem cells generated without viral integration. Science, 945-949.
Bibliography
Abuhatzira, L., Shemer, R., & Razin, A. (2009). MeCP2 involvement in the regulation of neuronal alpha-tubulin production. Human Molecular Genetics, 1415-1423.
Condic, M.L., & Rao, M. (2008). Regulatory Issues for Personalized Pluripotent Cells. Stem Cells, 2753-2758.
Dindot, S., Antalffy, B., Meenakshi, B., & Beaudet, A. (2008). The Angelman syndrome ubiquitin ligase localizes to the synapse and nucleus, and maternal deficiency results in abnormal dendritic spine morphology. Human Molecular Genetics, 111-118.
Dobkin, B. (2007). Behavioral, temporal, and spatial targets for cellular transplants as adjuncts to rehabilitation for stroke. Stroke, 832-839.
This means that while there are tremendous amounts of promise. The preferred method of embryotic cells is still the most utilized approach. However, in the future this could change dramatically. The reason why is because scientists have been aggressively pursuing this method. This is based on the fact that there are no ethical issues when conducting this kind of research and there is a possibility of having a major
but, Cuomo continued, Bush's position "…remains a minority view" (Hurlbut, 822). Christine Todd Whitman, who served Bush as administrator of the Environmental Protection Agency in Bush's first term (she served from January 2001 to May 2003), and was the first female governor of New Jersey, supported embryonic stem cell research. Whitman noted in her book that right after Bush was re-elected in 2004, Christian conservative organizer Phil Burress was heard
S. Law." Stem Cells at the National Academies. 2008. March 27, 2008. http://dels.nas.edu/bls/stemcells/ethics.shtml Thomson, James a., et al. "Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells." Science Express. Vol. 318. no. 5858, pp. 1917-1920: November 20, 2007. Yamanaka, Shinya, et al. "Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors." Cell. 131: 1-12.. November 30, 2007. March 27, 2008. http://images.cell.com/images/Edimages/Cell/IEPs/3661.pdf What are the potential uses of human stem
Stem Cell Ethics Debating the Ethics of Stem Cells The term 'stem cells' can mean different things to different people. For some, it conjures images of medical miracles providing solutions for heart disease, diabetes, and dementia. For others, it terrifies with a future filled with cloned humans. Still others cringe at the thought of mass producing cultured human embryos for the sole purpose of providing organs and tissues for a paying public.
A pre-embryo is the fertilized cell that has not yet been planted into the human host. Once the pre-embryo is implanted into the female host, it is assumed that it will grow and develop into a human being. The pre-embryo is not the same as the embryo, it is simply the raw material. A national bioethics committee has been assigned the duty of exploring these issues and making recommendations that
Conclusion This Technology Should Be Regulated and Controlled by Government There is not really much argument that stem cell research, regardless of its origin as embryonic or otherwise should be controlled to some degree by the government as the development of this research demonstrates a potential for abuse that is startling and could essentially be highly abused. The abuse of this type of research would likely be sourced in the desire of