Mayo Clinic Researchers Discover Link Article Critique

Length: 3 pages Sources: 2 Subject: Disease Type: Article Critique Paper: #2580705 Related Topics: Molecular, Things They Carried, Cell Biology, Ph
Excerpt from Article Critique :

The analysis was done in pairs, of healthy and preeclamptic placentas and by gestatational stage. In accordance with the standards set by the American College of Obstetricians and Gynecologists the placentas were grouped as "normal," "mild preeclampsia" and "severe preeclampsia," on the basis of recorded blood pressure of their mothers. There were certain well defined controls and parameters also placed like making sure those patients with diabetic and other disease histories that might affect blood pressure were not included in the experiment, the purpose was to study the causative agent of preeclampsia alone. The records showed that the significant amount of HtrA1 is present in the placental tissues of women with severe preeclampsia. In the light of this latest discovery it is hoped that this might lead to some sort of predictive test, which hitherto before did not exist for the early determination of preeclampsia. It is expected that this test will serve as early warning sign of preeclampsia and would permit the medical professionals to cope with the disease on non-crisis basis and possibly divert the situation in which the threat is posed to the life of mother and fetus,...


In keeping with the same premise that HtrA1 protein is linked with preeclampsia the next thing that needs to be determined is how exactly the whole mechanism is brought about, the possibility explained in this regard is also open to criticism and improvement. According to this because of their similar molecular structure as insulin-like growth factors (IGF) binding proteins, the HtrA1 protein fits in the placental sites and adversely affects the activities of cytotrophoblasts and thus leads to the defective placenta and fetus abnormality.

Even though this research is very insightful and interesting but it still lacks credentials to be reckoned as the groundbreaking or revolutionary because despite locating the protein this study is still not yet able to explain satisfactorily the pathway followed by protein to initiate the setting in of the disease. So until and unless the mechanism is known Preeclampsia remains elusive as ever. According to researchers at Mayo clinic the next area of study will target the protein's mechanism of bringing about the disease. Until then no predictive test can be devised for sure. The best prevention and control at present is to keep the patient under close supervision of the doctor or midwife because when detected earlier it's relatively easier to manage and many complications of the later stage can be avoided.


Mayo Clinic Researchers Discover Link between High Levels of HtrA1 Protein and Preeclampsia, a Complication of Pregnancy. Wednesday, February 01, 2006, Retrieved online 20th Jan, 2006 from 1

Elevated levels of a protein may warn of preeclampsia. Feb 2, 2006. Retrieved online 20th Jan, 2006 at

Sources Used in Documents:


Mayo Clinic Researchers Discover Link between High Levels of HtrA1 Protein and Preeclampsia, a Complication of Pregnancy. Wednesday, February 01, 2006, Retrieved online 20th Jan, 2006 from 1

Elevated levels of a protein may warn of preeclampsia. Feb 2, 2006. Retrieved online 20th Jan, 2006 at

Cite this Document:

"Mayo Clinic Researchers Discover Link" (2007, January 20) Retrieved January 21, 2022, from

"Mayo Clinic Researchers Discover Link" 20 January 2007. Web.21 January. 2022. <>

"Mayo Clinic Researchers Discover Link", 20 January 2007, Accessed.21 January. 2022,

Related Documents
Ectopic Pregnancy: Etiology, Modern Diagnosis
Words: 5051 Length: 18 Pages Topic: Health - Nursing Paper #: 25841647

Initial tests may be culdocentesis, hematocrit, a pregnancy test, a qualitative HCG blood test, a transvaginal ultrasound or pregnancy ultrasound and a white blood count test. An ectopic pregnancy can be distinguished from a normal intrauterine pregnancy through a rise in quantitative HCG levels. Declining B-hCG levels is indicative of an ectopic pregnancy (Kulp & Barnhart 2008). AD & C, laparoscopy and laparotomy tests will confirm the diagnosis (Chen). An

Consumption of a Carbohydrate Performance Drink Increase
Words: 3920 Length: 13 Pages Topic: Biology Paper #: 4635626

consumption of a carbohydrate performance drink increase 400m sprint times? Carbohydrate loading was found to be beneficial for endurance sports in the late 1990s. Research has demonstrated that consuming high amounts of carbohydrates, combined with low training levels for several days before an event can help to improve performance (Wade, 2008). Since that time, issues have arisen as to which types of carbohydrates are best, which proteins are a factor,

Obesity in America
Words: 5637 Length: 14 Pages Topic: History - Pre-Colonial America Paper #: 6164211

Obesity in the United States The extent of the Problem Obesity as one commentator says, is not just a "matter of aesthetics" but has become a major public health problem in the United States. Similarly, Federal health officials have categorically stated that "the growing prevalence of obesity in the United States represents a significant health threat to millions of Americans." Obesity is seen by health officials in a serious light and is

Parkinson's Disease Family and Cultural
Words: 1214 Length: 4 Pages Topic: Disease Paper #: 5499037

" (Fleming et al., 1994) B. Genetic Factors While environmental factors are shown to increase the risk of developing Parkinson's disease there are also specific mutations linked to the development of PD in certain populations. For example it is reported that a study conducted on Parkinson's Disease and hereditary genetic risks of developing this disease states findings that researchers in the study "...found that ethnic Chinese individuals carrying a mutation they indentified

Health Promotion
Words: 3496 Length: 10 Pages Topic: Health Paper #: 28197192

Health Promotion The absence of illness does not thoroughly explain "Health", it can as well be described as wellness of the body and mind. More technically, health can be defined from two perspectives -- bodily and psychological health. A state of well-being due to regular exercises, adequate nutrition, sufficient rest, sensitivity to signs of sickness and when to seek help is referred to as Physical health. A person's fitness is showcased

Prevention Through Herbs and Diet and What Constitutes a Healthy...
Words: 3364 Length: 10 Pages Topic: Business - Miscellaneous Paper #: 90378966

role of disease prevention through herbs and diet, and what constitutes a healthy lifestyle. Just about everyone knows that diet and exercise play a vital role in overall good health. Just about everyone knows that fresh fruits and vegetables should play an important role in a healthy diet. However, studies indicate that fresh herbs can also play a crucial role in a healthy diet, and may help prevent certain