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Clinical Trial Essays (Examples)

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Clinical Nurse Specialists and Nurse
Words: 2026 Length: 7 Pages Document Type: Term Paper Paper #: 59055950
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Since modern medicine can sustain patients with proper medical follow-up for years, it becomes incumbent on the profession to follow the patients and provide them with the knowledge and tracking to insure that they are observing the procedures and medications which prolong their quality of life. Given hospitals' short-term orientation with the patients, there is a need to bridge patient care before, during and after acute-care visits.

While there are some nursing specialties which can be regarded as solely hospital- or community-based, many of the specialties call for a more holistic notion of patient care. y combining the CNS and NP specialties, this profession has a better chance of assuring better patient outcomes, and a better quality of life for the patient.


ennett, .J. (1998). Psychiatric mental health nursing: thriving in a changing environment through outcomes-based measurements. Semin. Nurse Manage., 144-148.

erger, a.M.-F. (1996). Advanced practice roles for nurses…


Bennett, B.J. (1998). Psychiatric mental health nursing: thriving in a changing environment through outcomes-based measurements. Semin. Nurse Manage., 144-148.

Berger, a.M.-F. (1996). Advanced practice roles for nurses in tomorrow's healthcare systems. Clinical Nurse Specialist, 250-255.

Chaska, N.L. (2001). The Nursing Profession Tomorrow and Beyond. Thousand Oaks: Sage.

Cukr, P.L. (1997). The psychiatric clinical nurse specialist/nurse practitioner: an example of a combined role. Arch Psychiatr Nurs, 2-12.

Clinical Nurse Leader Role Implementing
Words: 4307 Length: 16 Pages Document Type: Research Paper Paper #: 71454882
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The American Association of Colleges of Nursing (AACN) and the Council on Graduate Education for Administration in Nursing (AACN, 1996; Dienemann & Aroian, 1995) operationally define the professional nurse as one who has been prepared with a minimum of a baccalaureate or higher degree in nursing. (Feldman & Greenberg, 2005, p. 219)

These were necessary requirement in the 90's. Now in an ever increasing age of need for more highly educated professional, the Clinical Nurse Leader armed with a Master's degree or better, is more adapted to handle a wide range of situations and create a fulcrum from which to balance all the staff in a given unit.

Literature eview

Clinical Nurse Leader

Kennedy, M.S.. (2004) Introducing the Clinical Nurse Leader. American Journal of Nursing, 104 (10), 22.

This article is a report regarding the decisions calling for a new role for nurses. The American Association of Colleges of Nursing…


Dalton, B., & Wright, L. (1999). Using Community Input for the Curriculum Review Process. Journal of Social Work Education, 35(2), 275.

Feldman, H.R. & Greenberg, M.J. (Eds.). (2005). Educating Nurses for Leadership. New York: Springer.

Kennedy, M.S.. (2004) Introducing the Clinical Nurse Leader. American Journal of Nursing, 104 (10), 22.

Knorr, R.S., Condon, S.K., Dwyer, F.M., & Hoffman, D.F. (2004). Tracking Pediatric Asthma: The Massachusetts Experience Using School Health Records. Environmental Health Perspectives, 112(14), 1424-1439.

International Clinical Harmonisation Proper Systems in Place
Words: 1196 Length: 4 Pages Document Type: Essay Paper #: 10839935
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International Clinical Harmonisation


The International Congress Harmonisation

WHO Principles of Good Clinical Practice

Clinical research is conducted to insure the safety and efficacy of health and medical products and practices (WHO 2002). In the past, randomized controlled trials gave most of the information about the safety and efficacy of these products and treatments. Randomized clinical trials were considered the foundation of evidence-based medicine but reliably only when conducted according to principles and standards. These principles and standards comprise good clinical research or GCP. The guidelines were created to help national regulatory authorities, sponsors, investigators and ethics committees to implement GCP for overall clinical research. These were based on the guidelines provided by major international organizations, such as the International Conference on Harmonization or ICH GCP, and used as reference (WHO).

GCP incorporates accepted and established ethical and scientific quality standards complied with for the design, conduct,…

Statistical vs Clinical Significance Statistical
Words: 649 Length: 2 Pages Document Type: Essay Paper #: 34387647
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In other words, p values correspond to statistical significance, while NNT corresponds to clinical significance. In clinical trials, statistical validity reflects the theoretical basis of the study, with hypotheses being formulated and quantified in terms of likelihood. Clinical significance is concerned with the practical outcome of trials, and with the results of actual treatment and how this relates to the hypotheses that are proven or void.


In nursing practice, both statistical and clinical significance play an important role in research. In practice, however, it is clinical significance that should have the greatest impact upon nursing practice. Clinical significance provides actual data from research conducted to determine such effects. It concerns the outcome of trials, while statistical significance is more concerned with determining new research and the likelihood of success before trials have been conducted.

Indeed, Davidson notes that an advantage of NNT is the format of its results --…


Davidson, Richard a. (1994) Does it Work or Not?: Clinical vs. Statistical Significance. Chest, Vol. 106, No. 3. Retrieved from

Kain, Z.N. (2005, Nov.) the Legend of the P. Value. Anesthesia & Analgesia, Vol. 101, No. 5. Retrieved from

Resolving Ethical Challenges in Clinical Tests
Words: 929 Length: 3 Pages Document Type: Essay Paper #: 51423116
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Ethical Factors in Clinical Testing

The conduct of the medics during their course of duty is regulated and governed by the established regulations relating to their profession. The basis of all these regulations is mainly to safeguard the rights of the patients. The patients must be accorded the utmost respect and handled in a dignified manner that makes them feel respected. It also covers what sort of equipment to be used in the case of an operation. Besides, regulations in the medical fraternity also cover the conditions of the treatment facilities such as the hospitals. The level of hygiene among other conditions is put into consideration. This paper focuses on the ethical issues that surround the observation of patients with Obstructive Sleep Apnea condition in the United States. This is a medical condition where a patient has difficulties breathing during sleep. However, it is unknown to these patients and can…


Brown, D.L. et al., (2011). Ethical Issues in the Conduct of Clinical Trials in Obstructive Sleep Apnea. J Clin Sleep Med. 2011 Feb 15;7(1):103-8.

Silverman H. (2007). Ethical Issues During The Conduct Of Clinical Trials. Proc Am Thorac Soc. 200 7 May;4(2):180-4; discussion 184.

Reconciling Clinical and Safety Databases
Words: 640 Length: 2 Pages Document Type: Essay Paper #: 24724690
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Clinical and Safety Databases

Clinical databases and safety databases are some of the most common types of databases utilized by clinical and drugs safety organizations to comply with different data standards. These databases differ significantly in various ways including the fact that safety databases have much more strict requirements for quality and safety. While safety databases are derived from clinical databases, they vary in relation to the kinds of data included in them, their maintenance, and how and when they are used in data management. Despite their differences, an important aspect of clinical data management process is reconciling the two databases. Clinical esearch Associates (CAs) play an important role in reconciling clinical and safety databases. However, CAs role in this process may be influenced by the nature of adverse events, progress of the clinical trial, and the use of coding dictionaries.

CA ole in econciling these Databases

As previously indicated,…


Krishnankutty et al. (2012, March-April). Data Management in Clinical Research: An Overview. Indian Journal of Pharmacology, 44(2), 168-172.

Ruiter, G. (n.d.). Handling and Reconciliation of SAE Data: A CRO Perspective. Retrieved February 24, 2016, from

The Origin and Evolution of Clinical Psychology
Words: 1158 Length: 4 Pages Document Type: Term Paper Paper #: 66335349
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old, the profession of clinical psychology is "one of the most vigorous fields of psychology," (eisman, 1991, p. 3). Clinical psychology refers generally to both social science research and application of that research to achieve specific clinical goals related to mental health. Since its inception in the 1890s, the field has changed and evolved dramatically (Benjamin, 2005). Earliest forms of clinical psychology included working with asylum patients, which often entailed using a variety of techniques that are now deemed unethical or harmful. The rise of psychoanalysis based on Freud's teachings led to the 20th century being an era in which talk therapy prevailed. esearch on different models of talk therapy has informed best practices in general. However, recent changes to the field of clinical psychology attempt to distinguish between the types of quantifiable evidence that can be gained from empirical research using psychopharmacological interventions on the one hand and less…


Barlow, DH (2011). The Oxford Handbook of Clinical Psychology. New York: Oxford University Press.

Benjamin, L.T. (2005). A history of clinical psychology as a profession in America. Annual Review of Clinical Psychology 1, 1-30.

Lilienfeld, S.O., Lynn, S.J. & Lohr, J.M. (2015). Science and Pseudoscience in Clinical Psychology. New York: The Guilford Press.

Reisman, J.M. (1991). A History of Clinical Psychology. New York: Brunner-Routledge.

Double Blind Trial This Is a Study
Words: 538 Length: 2 Pages Document Type: Essay Paper #: 84803966
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double blind trial. This is a study where neither the researchers or the participants know what they will receive. First and foremost, it removes any potential for bias, as there are no preconceived notions from the participants or those studying the reactions of the trial. Such studies often also "follow less restrictive methodological standards than phase III studies in terms of patient selection, comedictation, and other design issues," (Muller, 2011). Essentially they have greater room to better replicate real world scenarios. They are also much more able to be generalized than studies with more restrictions. However, there are also some downsides to double blind trials. For example, there is a much greater variance that the research will have to deal with. This is "caused by the different kinds of confounders as well as problematic design issues" that can lead to "wrong conclusions," (Muller, 2011). When there are issues it is…


Constanta, R. (2008). An integrative approach to quality of life management. Sapient 1(1), 12-16.

Muller, Hans-Jurgen. (2011). Effectiveness studies: Advantages and disadvantages. Dialogues on Clinical Neuroscience, 13(1), 199-207.

Lewis, John A. (2002). Study designs, duration, and choice of comparators including the use of placebo. Dialogues in Clinical Neuroscience, 4(4), 463-469.

Ethical Case Study Regarding Randomised Medical Trials in a Developing Country
Words: 1290 Length: 2 Pages Document Type: Essay Paper #: 36304730
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Global Healthcare Ethics and the andomised HIV Trial

Healthcare professional face a range of ethical issues in the pursuance of their vocation. In the context of HIV research and the conducting of research among vulnerable population, such as poor expectant mothers in developing countries, the compete of global health ethics should provide a foundation for the assessment of ethical practices, both in planning, undertaking, and reviewing the work (WHO, 2014; Stapleton et al., 2013). Global health ethics is an interdisciplinary field, which covers not only health research, but also issues such as the provision of healthcare, and development of health policy, with the aim of understanding the moral values which should be implemented at a global level, undertaken utilising a predominantly geographic approach to macro level health issues (Stapleton et al., 2013). In this context, global health ethics is primarily concerned with issues such as pandemics, the effects of natural…


Kass. N.E., (2000), An Ethics Framework for Public Health, American Journal of public health, 91, 1776-1782

Pinto, A D; Upshur,, (2009), Global health Ethics for Students, Developing World Bioethics, 9(1), 1-10

Stapleton, G; Schroder-Back, P; Laaser, U; Meershoek, A; Popa, D, (2013), Global health ethics: an introduction to prominent theories and relevant topics, Global Health Action, 7, 235-69

World Health Organization, (WHO), (2014), Global Health Ethics, retrieved 19th December 2015 from

recent evidence from randomized trials
Words: 1326 Length: 4 Pages Document Type: Journal Professional Paper #: 92326070
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Programs for Parents of Infants and Toddlers: ecent Evidence From andomized Trials

My initial thoughts and feelings were:

Infancy is a very important stage in children's development. It is at this stage that children are most receptive to both mental and physical change and they are at greater risk of potentially harmful influences than their older counterparts. Infants also get affected much more by parental disruptions than older kids. It has been shown that parent-child interactions during the early stages are great predictors of several late and early developmental outcomes. Lending parents support in coming up and implementing good parenting skills can lead to great child development (Pontoppidan, Klest & Sandov, 2016). Since the child is most malleable during infancy, experiences at this stage shape the child's behavior, wellbeing and brain development and so the effects can last for the entire life of the infant. Parenting interventions given to newborn…


Olds, D. L., Sadler, L., & Kitzman, H. (2007). Programs for parents of infants and toddlers: recent evidence from randomized trials. Journal of child psychology and psychiatry, 48(3-4), 355-391.

Pontoppidan, M. (2015). The effectiveness of the Incredible Years™ Parents and Babies Program as a universal prevention intervention for parents of infants in Denmark: study protocol for a pilot randomized controlled trial. Trials, 16(1), 386.

Pontoppidan, M., Klest, S. K., & Sandoy, T. M. (2016). The Incredible Years Parents and Babies Program: A Pilot Randomized Controlled Trial. PloS one, 11(12), e0167592.

Sadler, L. S., Slade, A., Close, N., Webb, D. L., Simpson, T., Fennie, K., & Mayes, L. C. (2013). Minding the baby: Enhancing reflectiveness to improve early health and relationship outcomes in an interdisciplinary home-visiting program. Infant mental health journal, 34(5), 391-405.

Vaccine Trial
Words: 405 Length: 1 Pages Document Type: Essay Paper #: 54708338
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IRB's add a certain and authentic stamp of approval for research and clinical trials. This system is by no means perfect, as there are countless examples of how IRB's failed, but in this particular instance where a Central African country may be exposed to a vaccine, this oversight is deemed necessary. The IRB needs to understand what is the purpose of these tests and how the population of this vulnerable nation may benefit from this research. Historically, this region of the world has been used as a virtual Petri dish for Western scientists wishing to test their new medical breakthrough. Caution is necessary.

The ethical conflicts are obvious. There are profit motives in mind for the vaccine, as they are valuable commodities in many parts of the world. The IRB can act as an ethical buffer by creating a circumstance where the research can be done humanely, and with a…

Clinical Staging of Psychiatric Disorders
Words: 1272 Length: 3 Pages Document Type: Essay Paper #: 74939890
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DSM diagnostic criteria have long been a source of criticism. McGorry, Hickie, Yung, Pantelis, and Jackson (2006) point out some basic deficiencies of the DSM diagnostic system. First the authors state that the function of a diagnosis is to state what treatment should be applied or predict the prognosis of the condition. These are certainly functions of a diagnosis, but a diagnosis has broader implications. First and foremost the idea of having a diagnosis is to take a series of related signs and symptoms that hang together consistently and label them so as to facilitate communication between health care professionals. A diagnosis alone is useless unless it allows professionals to communicate about the same entity. Then descriptions of course, treatment, and prognosis can follow.

McGorry et al. charge that in the DSM system the clinical features that occur early in the course of the disorder are not distinguished from those…


Fava G.A. & Kellner, R. (1993). Staging: a neglected dimension in psychiatric classification. Acta Psychiatrica Scandinavica, 87, 555-558.

Fava, G.A. & Tossani, E. (2007). Prodromal stage of major depression. Early Intervention in Psychiatry, 1, 9-18.

Hetrick, S.E., Parker, A.G., Hickie, I.B., Purcell, R., Yung, A.R., & McGorry, P.D. (2008).

Early identification and intervention in depressive disorders: Towards a clinical staging model. Psychotherapy and Psychosomatics, 77, 263-270.

Alzheimer Disease
Words: 640 Length: 2 Pages Document Type: Essay Paper #: 19606698
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Clinical Trial NCT01504854

The number of Americans with Alzheimer's disease and other dementias will grow as the U.S. population age 65 and older continues to increase. It is projected more than 3 million people aged 85 and older are likely to have Alzheimer's, when the first wave of baby boomers reach age 85 in the year 2031 (Alzheimer's Association, 2015). By 2025, the number of people age 65 and older with Alzheimer's disease is estimated to reach 7.1 million -- a 40% increase from the 5 million who are age 65 and older currently affected (Alzheimer's Association, 2015). Alzheimer's disease is the most common type of dementia and is projected to be one of the most prevalent illnesses with our older adult population in the future. Alzheimer's disease remains 100% fatal and there is no cure for the disease; however, there are medications that are believed to be able to…


Alzheimer's Association. (2015). (2015). Resveratrol for Alzheimer's disease. Clinical trials identifier NCT01504854. Retrieved on March 14, 2015 from .

Forensic and Clinical Roles and Assessment While
Words: 1410 Length: 4 Pages Document Type: Term Paper Paper #: 27727725
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Forensic and Clinical oles and Assessment

While psychologists and psychiatrists may engage in both clinical and forensic practice, it important to recognize that clinical and forensic practice are distinct areas of practice. This means that the role of the forensic and clinical practitioner differs in several ways: "who the client of the psychologist is the nature of the relationship between the psychologist and the individual being evaluated, and the psychologist's approach to the material provided by the individual" (Packer, 2008). Moreover, it also means that the professional assesses the individual differently. These differences include: the purpose of the assessment, the goal of the intervention, and psycho-legal vs. psychological assessment. While the differences may seem clear, the reality is that even forensic evaluations can lead to the establishment of the type of relationships that develop in clinical practice, making it difficult for health care professionals and for their clients to differentiate…


American Psychological Association. (2011). Specialty guidelines for forensic psychologists.

Retrieved September 8, 2013 from American Psychology-Law Society website:

Diabetes Management

Early Detection and Management of Diabetic Neuropathy in a Clinical and Homecare Setting

The objective of this study is to examine early detection and management of diabetic neuropathy in a clinical and homecare setting and specifically through examination of articles published after 2002. The information from each source will be summarized listing the strengths and weaknesses of each article in separate paragraphs. As well, this work will utilize table or graphs to present the findings.

O'eilly, Caryl Ann (2005) Managing the Care of Patients with Diabetes in the Home Care Setting, Diabetes Spectrum, July 2005. Vol. 18. No. 3. etrieved from:

The work of O'eilly (2005) reports that more patients than ever before are released earlier from hospitals and rehabilitation center and that those with diabetes are included in this trend. Diabetes is reported to be ranked second following congestive heart failure as the primary diagnosis at…


Zieger, Anne (2009) Studies Offer Mixed Grades for Remote Diabetes Care. 6 July 2009 Retrieved from FierceHealthIT at: 

O'Reilly, Caryl Ann (2005) Managing the Care of Patients with Diabetes in the Home Care Setting, Diabetes Spectrum, July 2005. Vol. 18. No. 3. Retrieved from: 

McLaughlin, Sue (2005) From Research to Practice/Diabetes Care in Special Settings: Meeting the Challenges: Diabetes Care in Special Settings Diabetes Spectrum July 2005 18:143-145. Retrieved from:

Medical Experiments
Words: 946 Length: 3 Pages Document Type: Term Paper Paper #: 75410058
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Ethical Dilemma: case study of clinical trial on a child

The field of medicine and research has been surrounded by issue of experiments in order to have the conclusive result of the effectiveness of a drug or otherwise. These results can only be obtained if the drugs are at times used on human beings with the real medical problem that the experiment seeks to find solution to. The problem of ethical dilemma often comes in at such stages on whether to go ahead to experiment on the effectiveness of the new drug or not.

Ethical dilemma refers to the situation that is deemed complex since it involves some element of mental conflict between moral imperatives that is one goes ahead and obeys one, it will mean the transgression of another (Braunack-Meyer A.J., 2001). The individual does not have a clear cut direction on which option to go for, despite there…


Braunack-Meyer A.J., (2001). What makes a problem an ethical problem? An empirical perspective on the nature of ethical problems in general practice. Retrieved November 29, 2014 from 

Pier B.K., (2007). Children, Gillick Competency and Consent for Involvement in Research. Retrieved November 29, 2014 from 

Spriggs M., (2010). Understanding Consent in Research Involving Children: The ethical Issues. Retrieved November 29, 2014 from

Drug Tysabri That Was Tested
Words: 649 Length: 2 Pages Document Type: Term Paper Paper #: 97795125
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According to these authors, the fatal tragedy could easily have been avoided by taking more time for more focused and carefully planned clinical trials. According to this view, it was unethical to test Tysabri in the way it has been done, and furthermore irresponsible to enter it into the market before all side-effects were ascertained.

3. Interested parties: The interested parties in this case include Walter Smith, Anita's widower, as well as Cambridge biotechnology and Elan Corp. From Smith's point-of-view, the companies are at fault for causing harm to his wife, and potential harm to many others using the drug. His current assertions regarding the reentry of the drug into the market appear to be well thought out and mature, focusing on the future benefit of patients rather than on his own need for revenge.

From the point-of-view of the companies, the drug is developed to help those suffering from…

Online Disease Management Programs
Words: 682 Length: 2 Pages Document Type: Capstone Project Paper #: 37425340
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Technology in Managing Data in Clinical Trials

Technology can assist in several ways in a healthcare setting. From use of big data to use of technology for effective disease management, technology gives hospitals and other healthcare facilities a chance to examine patient information faster and easier. Because clinical trials are an important aspect to pharmaceuticals and thus disease management, research needs to point in the direction of how technology can offer a means of managing data efficiently and effectively. Big data is one such use for technology and can be used in clinical trials, especially clinical trials with a large number of participants.

In a 2014 study, researchers attempted to identify six use cases where there can be introduction of big data use. "Six use cases where some of the clearest opportunities exist to reduce costs through the use of big data: high-cost patients, readmissions, triage, decompensation (when a patient's…


Bates, D., Saria, S., Ohno-Machado, L., Shah, A., & Escobar, G. (2014). Big Data In Health Care: Using Analytics To Identify And Manage High-Risk And High-Cost Patients. Health Affairs, 33(7), 1123-1131. 

Tang, P., Overhage, J., Chan, A., Brown, N., Aghighi, B., & Entwistle, M. et al. (2013). Online disease management of diabetes: Engaging and Motivating Patients Online with Enhanced Resources-Diabetes (EMPOWER-D), a randomized controlled trial. Journal of The American Medical Informatics Association, 20(3), 526-534.

Factors Affecting Recruitment
Words: 681 Length: 2 Pages Document Type: Case Study Paper #: 6542206
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ecruitment and etention

For any clinical trials, there are bound to be subjects who volunteer to take part in the trials and in recruiting and working with these subjects, it is important to ensure that they are treated as ethically as is also important to ensure that the procedure gives the best possible results which reflects the true effect and response from the subjects. Due to the stringent nature of most recruitments, there are factors that are bound to affect the process in a positive as well as in a negative manner.

The positive aspects that often affect recruitment and make it successful are such as the awareness of the candidates on the expectations that the investigator has on them hence reducing anxiety and uncertainty hence high rates of turn out and participation that will make the recruitment process end up with quality subjects. The other positive factor is…


Sandra Williams, (2004). Clinical Trials Recruitment and Enrollment: Attitudes, Barriers, and Motivating Factors. Retrieved July 23, 2015 from 

Sullivan J., (2004). Subject Recruitment and Retention: Barriers to Success. Retrieved July 23, 2015 from

Sponsored by Roche Laboratories a
Words: 890 Length: 3 Pages Document Type: Thesis Paper #: 61716681
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The sample population for the stomach cancer trials included 594 patients that were Her2 positive. It is not known if patients in the stomach cancer trial included both males and females. Exclusionary criteria were not made available for either of the studies. All of the patients were receiving standard chemotherapy treatments, in addition to receiving Herceptin (Pollack, 2009). The sample populations for these studies were large for a clinical trial. Many times, it is difficult to find patients that fit the criteria for inclusion in the study. This was not a problem for these studies. The sample population of the study improves the validity of the study and confidence in the drug to be effective in patients that meet the criteria for administration of Herceptin.

The study design in both cases used a comparative study. One group was the test group and would receive the treatment being tested, in this…


F. Hoffman-L Roche Ltd. (2009). Herceptin (Trastuuzumab). Retrieved June 6, 2009 from .

Pollack, A. (2009). Promising Results in Stomach and Breast Cancer Drugs. The New York

Times. May 31. 2009. Retrieved June 7, 2009 from

Evista® Raloxifene Hydrochloride the Evista®
Words: 1131 Length: 4 Pages Document Type: Term Paper Paper #: 87552851
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Therapy was discontinued due to an adverse event in 11% of EVISTA®-treated women and 9% of placebo-treated women. Common adverse events related to EVISTA® therapy were hot flashes and leg cramps. Hot flashes were most commonly reported during the first 6 months of treatment and were not different from placebo thereafter.


Cholestyramine causes a 60% reduction in the absorption and enterohepatic cycling of raloxifene after a single dose. Thus, co-administration of cholestyramine with EVISTA® is not recommended.


Overall, raloxifene exerts similar positive on bone mineral density and bone turnover as other SEMS and estrogen therapy. However, the reduction in fracture risk is improved with SEMs vs. estrogen (Nakamura 632).


Overall, administration of calcium and vitamin D is more effective and economical than any approved drug for postmenopausal osteoporosis. The annual cost of calcium and vitamin D treatment is $22 compared to $255 for estrogen,…


Barrett-Connor, E., et al. "Risk-Benefit Profile for Raloxifene: 4-Year Data from the Multiple Outcomes of Raloxifene Evaluation (More) Randomized Trial." J. Bone Miner Res 19.8 (2004): 1270-5.

Borgstrom, F., et al. "Cost Effectiveness of Raloxifene in the Treatment of Osteoporosis in Sweden: An Economic Evaluation Based on the More Study." Pharmacoeconomics 22.17 (2004): 1153-65.

Bryant, H.U. "Mechanism of Action and Preclinical Profile of Raloxifene, a Selective Estrogen Receptor Modulation." Rev Endocr Metab Disord 2.1 (2001): 129-38.

Cranney, a., et al. "Meta-Analyses of Therapies for Postmenopausal Osteoporosis. Iv. Meta-Analysis of Raloxifene for the Prevention and Treatment of Postmenopausal Osteoporosis." Endocr Rev 23.4 (2002): 524-8.

Authors Communicate There Are a Number of
Words: 950 Length: 3 Pages Document Type: Essay Paper #: 45112597
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Authors Communicate

There are a number of points of interest regarding "Massage therapy in post-operative rehabilitation of children and adolescents with cerebral palsy - a pilot study." On the whole this is an extremely well-organized article, which is one of its primary strengths. The different sections and phases of the research are well documented. There are a variety of tables that elucidate several components related to the literature review, the results, and the particulars of the subjects considered in the research. However, there is more than one area of the study in which the researchers could have benefited from the use of more substantial effort and a more thorough methodology, which is certainly reflected in the results and the conclusion.

The central weakness of this study is the fact that all of the results were based on research performed on just six subjects. To the credit of the researchers they…


O'Conner, P. (2003). Woe is I: The grammarphobe's guide to better English in plain English. New York: Riverhead Books

International Congress on Harmonization
Words: 1017 Length: 3 Pages Document Type: Term Paper Paper #: 90526736
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International Congress on Harmonization

Clinical research guidelines

There are various bodies that are concerned with the stipulation of guidelines and rules that need to be followed within the medical field and in specific the clinical research areas. The guidelines have been summarized by the International Conference on Harmonization (ICH) into five major areas: those dealing with quality, safety, efficacy and multidisciplinary topics. Within the patient care discipline, guidelines are designed predominantly to support decision making process and the content of these guidelines are based on data from the evidence based approach that has been gathered over time hence has a wide application and reach. Evidence-based care has been gaining ground in the recent years, propagated by the clinicians, managers and even politicians who are concerned about the quality standards. This has further heightened the need and requirement of standards among the practitioners in the healthcare sector (Open Clinical, 2013).



BMJ, (1999). Potential benefits, limitations, and harms of clinical guidelines. Retrieved December 6, 2014 from 

International Conference on Harmonisation, (2014). ICH Guidelines. Retrieved December 6, 2014 from 

Open Clinical, (2013). Clinical Practice Guidelines. Retrieved December 6, 2014 from

Ethics Case Study -- Roche
Words: 499 Length: 2 Pages Document Type: Term Paper Paper #: 11558561
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However, if it were the case that the Chinese legal system protected the innocent and executed only those criminals who have been properly, duly, and fairly convicted and sentenced for crimes appropriately punished by execution, it is much harder to argue against the use of their organs to benefit society. From an objective point-of-view, once a person dies, it is wasteful not to use his or her organs to benefit living people. The attachment we have to the body after death is primarily a function of social learning and nonsensical superstition in the first place. Logically, it would be ethically permissible, to require that organs be harvested from all deceased persons once their families have had the opportunity to pay their respects.

The ethical problem in this case is much more about the way that Chinese citizens become prisoners in the first place and the way that the decision to…

The Use of Probability Values in Statistical Testing
Words: 848 Length: 2 Pages Document Type: Essay Paper #: 61379916
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Suitable P-Value for a Clinical Trial

Statistical testing to determine whether results are significant is extremely useful in all types of research. In most cases, where a significant level, or p-value, is being chosen, a p-value of .05 is deemed to be sufficiently accurate. However, while this may be suitable for many types of research, it may be argued that in clinical trials from drugs, a lower p value may be more appropriate, due to the nature of the research. To understand this, it is necessary to understand what the p-value is, what it signifies.

The p value gives a probability, but is easy to misunderstand, as it indicates the level of support for the null hypothesis, with the probability level used to determine whether to accept or reject the null hypothesis. The p-value provides the probability of gaining an effect at the same level if the null hypothesis is…


Berenson, A, (2006, May 31), Merck Admits a Data Error on Vioxx, The New York Times, retrieved 13 November 2015 from 

Cowen, G. (1997). Statistical Data Analysis. Oxford: Oxford University Press.

New Respiratory Drugs
Words: 1672 Length: 5 Pages Document Type: Research Paper Paper #: 24708838
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new respiratory drugs that have been approved for medical use over the past decade. The paper will highlight the diagnoses of the drugs i.e. when and why it is prescribed, how it is meant to be used and how often, its side effects, the impact for a missed dose or an overdose along with any other relevant information that will add depth to it appropriate use.

The main purpose for the respiratory drugs is to help cure the ailments directly or indirectly related to the functioning of lungs or general breathing of an individual. There are numerous sectors where studies on new respiratory drugs can be carried out and some of the most recent studies to include this particular aspect include allergies, asthma attacks, Acute espiratory Distress Syndrome (ADS), pneumonia and sinus infections.

In this paper we will focus on the following new respiratory drugs: Arcapta, Daliresp, Dulera, Tyvaso, Alvesco,…


Beeh, K.M., Derom, E., Kanniess, F., Cameron, R., Higgins, M., van As, A. (2007). "Indacaterol, a novel inhaled beta2-agonist, provides sustained 24-h bronchodilation in asthma." Eur. Respir. J. 29 (5): 871 -- 8.

Cerner Multum, Inc., (2010). Dulera Inhaler. Accessed 02-02-12 from: 

Cerner Multum, Inc., (2010a). Tyvaso. Accessed 02-02-12 from: 

Cerner Multum, Inc., (2010b). Alvesco. Accessed 02-02-12 from:

Market Driven Management
Words: 25695 Length: 75 Pages Document Type: Term Paper Paper #: 32150042
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Pharmaceutical industries have to operate in an environment that is highly competitive and subject to a wide variety of internal and external constraints. In recent times, there has been an increasing trend to reduce the cost of operation while competing with other companies that manufacture products that treat similar afflictions and ailments. The complexities in drug research and development and regulations have created an industry that is subject to intense pressure to perform. The amount of capital investment investments required to get a drug from conception, through clinical trials and into the market is enormous. The already high-strung pharmaceutical industry is increasingly investing greater amounts of resources in search of the next "blockbuster" drug that can help them gain market position and profits. Laws, regulations and patents are important to the industry while spending billions of dollars in ensuring the copyright of their products.

It is the intention of this…


Ansoff, H.I. (1957). Strategies for diversification. Harvard Business Review, 35(5), 113-124.

Ansoff, H.I. (1965). Corporate Strategy. New York, NY: McGraw-Hill.

Ashour, M.F., Obeidat, O., Barakat, H., & Tamimi, A. (2004). UAE Begins Examination of Patent Applications. Retrieved January 18, 2004, from the World Wide Web: 

Bain, J.S. (1954). Economies of scale, concentration, and the condition of entry in twenty manufacturing industries. American Economic Review, 44, 15-36.

Nursing Mindfulness and its impact
Words: 1585 Length: 5 Pages Document Type: Essay Paper #: 52739138
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PICOT Question and its Significance

The PICOT question is: Does mindfulness meditation (I) reduce long-term risk factors and suicidal behaviors (O) among psychiatric patients (P) versus those who do not participate in the meditation programs (C)? This is of great significance to the nursing practice because psychiatric disorders are risk factors that cause an increase in the probability of a suicidal occurrence. As a result, it is imperative for psychiatric nurses to comprehend how to pinpoint such risk factors and institute a clinical practice setting that dissuades suicide. More importantly, nursing practice encompasses the execution of best practices for generating a clinical setting that diminishes risk such as mindfulness meditation.

Summary of Literature Review

The mindfulness meditation theory is deemed to the most prospective one in treating addictive disorder patients. The safety of these models is guaranteed if carried out in the framework of clinical studies. In recent periods, associated…

Improving the Quality of Medical
Words: 4818 Length: 18 Pages Document Type: Research Paper Paper #: 29120759
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This is particularly the case in sub-Saharan Africa where clinicians have often come to rely on signs and symptoms alone to make diagnoses." (Nicoll, Walraven, Kigadye, Klokke, 1995)

The laboratory environment is critical to administering testing to determine population rates of HIV / AIDS throughout nations and perhaps continents where the lacking of resources facilitates a substandard environment for care. In the case of the African nation of Mozambique, which perhaps can be understood as a case indicative of the environmental assessment one would find throughout Africa and therefore, can be labelled to be a median statistical nation. A nation representing the median would indicate that half of the population nations that are categorized as resourced deficient, half would be above Mozambique in terms of resource allocation and half would fall below.

esearch into the quality of HIV / AIDS case-detection and case-reporting system in Mozambique was conducted by (Chilundo,…


Chappuis, F., Loutan, L., Simarro, P., Lejon, V., and Buscher, P. Options for Field Diagnosis of Human African Trypanosomiasis. Clinical Microbiology Reviews, January 2005, p. 133-146, Vol. 18, No.1

Chilundo, B., Sundeep S., Sundby J. The Quality of HIV / AIDS case-detection and case reporting systems in Mozambique. African Journal of AIDS Research 2004, 145-155. Copyright NISC Pty Ltd.

Clark. Blood Safety PPT. CDC, WHO

Loefler, I. Surgical wound infection in the Third World: the African experience. Journal of Medical Microbiology. Volume 47, 471-473. 1998. The Pathological Society of Great Britain and Ireland

Alliance Strategy Analysing the Continuous
Words: 783 Length: 2 Pages Document Type: Term Paper Paper #: 34210009
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" Concerning the type of complementary strategic alliance, it is a horizontal one, because it is formed "when partners who agree to combine their resources and skills to create value in the same stage of the value chain," it is focused "on long-term product development and distribution opportunities" and "the partners may become competitors which requires a great deal of trust between the partners."

The answer to the second question is "no," it's not a "competition response strategy" because the two companies are not really competitors, even if the profile for both company is pharmaceutical. Excel research can be consider in this case as an ally, a support for Century Pharmaceuticals, and even as a consultancy company that works for C.P.

The answer to the third question is "yes," it can be an" uncertainty reducing strategy" because if it functions as it is established, it can reduce the uncertainty about…


1. Hitt Michael a., Ireland R. Duane, Hoskisson Robert a. "Cooperative Strategy." Power Point Presentation by Charlie Cook, the University of West Alabama, and ©2007 Thomson South - Western. All right reserved.

Hitt Michael a., Ireland Duane R., Hoskisson Robert a."Cooperative Strategy" ppt, pg. 9-8

Hitt Michael a., Ireland Duane R., Hoskisson Robert a."Cooperative Strategy" ppt, pg. 9-2

Hitt Michael a., Ireland Duane R., Hoskisson Robert a."Cooperative Strategy" ppt, pg. 9-3

Internet Information Quality Whitehouse gov vs Whitehouse net Whitehouse Gov
Words: 536 Length: 2 Pages Document Type: Research Paper Paper #: 1332518
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Internet Information Quality vs., under first impressions is accurate, far more professional, and updated. In fact, is outdated and still has George . Bush as the President. is extremely informative, but focused on the current President, Barak Obama, and his agenda. The site is divided into photos and videos of conferences, appearances, and there is a briefing room that focuses on the major issues of the day. The site is appropriate for education, it has information about the way the government worlds, and about the topics that are in the news -- immigration, gun violence, energy policy, and more. The site is current with top political news of the day, the visits, and the travel plans of the President and his staff. There is a link for email updates, contact information, and a way to receive answers back from various departments of the government. Ironically,…

Works Cited:

Harris, R. (2007, June). Evaluating Internet Research Sources. Retrieved from: 


Sanchez, C., et al. (2006). ICLS 2006 Proceedings of the 7th International Condernce

Patient Access to Experimental Drugs Experimental Drugs
Words: 1002 Length: 3 Pages Document Type: Term Paper Paper #: 10313424
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Patient Access to Experimental Drugs

Experimental drugs are being used in treating cancer and other life-threatening diseases in the hopes that effective cures and treatments can be identified. There are however, ethical questions relating to the use of experimental drugs and this work seeks to answer the question that asks whether patients should have access to experimental drugs and to answer why or why they should not have this access.

Experimental Drugs

Experimental drugs have carved inroads to treating cancer patients and most recently; this has been reported in the form of a drug that serves to "neutralize two mechanisms cancers need to survive." (Coghlan, 2012) The new drug is Cabozantinib. This drug is reported by one individual interviewed in this study to have been used by a family member who died while taking the drug for non-small cell carcinoma in the form of lung cancer. When asked the question…


Beauchamp, TL and Childress, JF (2001) Principles of Biomedical Ethics. Oxford University Press. 15 Feb 2001. Retrieved from: 

Coghlan, A.K (2012) New Cancer Drug Sabotages Tumor's Escape Route. 24 Feb 2012. New Scientist. Retrieved from: 

Beauchamp, TL and Childress, JF (2001) Principles of Biomedical Ethics. Oxford University Press. 15 Feb 2001. Retrieved from:

Treatments for Rosacea
Words: 740 Length: 2 Pages Document Type: Research Paper Paper #: 36655106
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Treatments for Rosacea

Rosacea is a medical condition characterized by reddening of the skin. The face primarily will turn red in hue. Sores may appear on the skin as well. The face may also swell to some degree. It is an unfortunate condition where patients not only have to deal with the illness itself, but also with psychological ramifications from feeling unattractive due to the skin pigments or lesions. Although there is currently no cure for Rosacea, scientists have researched various treatments to help patients suffering from the condition.

In the article, "Treatment of Rosacea with Intense Pulsed Light," researchers Papageorgiou et. al consider how ultra violet and pulsed light might positively treat skin conditions like Rosacea. During this particular experiment, the researchers tested 34 patients who were given treatments every three weeks for a total of twelve weeks. More than 70% of patients experienced at least a 50% reduction…

Works Cited

Lee, DH, Li, K.K., & Suh, DH "Pimecrolimus 1% Cream for the Treatment of Steroid-

Induced Rosacea: an 8-week Split-Face Clinical Trial." British Journal of Dermatology. (158:5). 2008. 1069-76. Print.

Papageorgiou, P.P., Clayton, W.W., Norwood, S.S., Chopra, S.S., & Rustin, M.M. "Treatment of Rosacea with Intense Pulsed Light: Significant Improvement and Long-Lasting Results." British Journal of Dermatology. (159:3). 2008. 628-32. Print.

Sharquie, K.E., Najim, R.A., & Al-Salman, H.N. "Oral Zinc Sulfate in the Treatment of Rosacea: a Double-Blind, Placebo-Controlled Study." International Journal of Dermatology. (45:7). 2006. 857-61. Print.

Activities Whether They Are Experimental
Words: 2978 Length: 10 Pages Document Type: Term Paper Paper #: 93074109
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With respect to the McGuckin studies neither randomization nor sample selection is ever discussed. In fact sampling per se is not presented except for cursory mention in the results section. Again, without proper identification as to the sampling method implemented, the reader is ever cautious as to how legitimate the results will be. Not wanting to pre-empt the discussion on statistical methodology, mention must be made at this time with respect to the Poisson egression statistical tool selected for use in these two studies in terms of sampling. This particular regression technique, if utilized properly, requires the sample size to be determined on the basis of the square root transformation of the Poisson random variables. More specifically, the formula for calculating the sample size of the Poisson variables is as follows:

2) 2

The data received from this calculation will give the research investigator the number of sampling units per…


Armitage P. And Berry, G. (1994) Statistical Methods in Medical Research (3 rd edition).

London: Blackwell Publishing.

Connor, E.F., Hosfield, E., Meeter, D. And X. Nui. (1997). Tests for aggregation and size-based sample-unit selection when sample units vary in size. Ecology 78: 1238 -1249.

Corning, S.P. (2002). Profiling and developing nursing leaders. Journal of Nursing

Measurements Health Care Required Resources Media Course
Words: 1039 Length: 3 Pages Document Type: Essay Paper #: 61294834
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Measurements Health Care equired esources Media Course Media: Organizational Systems Leadership

The metrics used in the balanced scorecard and dashboard are both qualitative and quantitative, and can result in improvement in health care services (Frith et al., 2010, p. 10). As such, they play a significant influence in the nursing practice for different organizations, because they provide an objective means of measuring various aspects of health care services. Specifically, the balanced scorecard and dashboards stratifies health care into four primary components: training for health care workers, resources for facilities, provision of service and community satisfaction (Chan et al., 2010, p. 709). These metrics are principally used to inform health care practitioners about specific areas of improvement, or those in which they are providing excellent service and resources. In several instances, the metrics for the individual areas of analyses were developed by evaluating and comparing national standards (Chan et al., 2010,…


Chan, G.J., Parco, K.B., Sihombing, M.E., Tredwell, S.P., & O'Rourke, E.J. (2010). Improving health services to displaced persons in Aceh, Indonesia: A balanced scorecard. Bulletin Of The World Health Organization, 88(9), 709 -- 712.

Frith, K.H., Anderson, F., & Sewell, J.P. (2010). Assessing and selecting data for a nursing services dashboard. Journal of Nursing Administration, 40(1), 10 -- 16. doi:10.1097/NNA.0b013e3181c47d45

Grossmeier, J., Terry, P.E., Cipriotti, A., & Burtaine, J.E. (2010). Best practices in evaluating worksite health promotion programs. American Journal of Health Promotion, 24(3), TAHP 1 -- 9.

Schalm, C. (2008). Implementing a balanced scorecard as a strategic management tool in a long-term care organization. Journal of Health Services Research & Policy, 13(Supp.1), 8-14.

Benefits and Risks of Lochol
Words: 650 Length: 2 Pages Document Type: Case Study Paper #: 19263513
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This prescription medicine is a hard capsule, which comes in sizes 1 and 3 and in 20 mg and in 10 mg (MIMS, 2010). Manufactured by Clonmel Healrhcare Ltd., its active ingredient is fluvastatin. Size 3 has 20 mg of the active ingredient and with a white body and a blue cap. Size 1 has a white body and a green cap (MIMS).


Lochol is indicated for primary hypercholesterolaemia and mixed dyslipidaemia or high cholesterol (MIMS, 2010). It supports the diet of individuals suffering from high total cholesterol levels and low density lipoprotein cholesterol levels and their modified diet and other treatments are insufficient or inadequate in managing the condition (MIMS).

Lochol is also prescribed to patients suffering from coronary heart disease and for the adjust prevention of coronary conditions, which can follow coronary transcatheter treatment (MIMS, 2010). These include cardiac death, myocardial infarction, which is not fatal,…


Gutierrez, D. (2010).. Statin drugs cause liver damage, kidney failure and cataracts. Natural News: British Medical Journal. Retrieved on July 16, 2015 from

Horishige, I. et al. (2011). Long-term event monitoring study of fluvastatin in Japanese patients with hypercholesterolemia: efficacy and incidence of cardiac and other events in elderly patients. Vol. 57, Issue # 7, Journal of Cardiology: Japanese College of Cardiology. Retrieved on July 16, 2015 from

MIMS (2010). Lochol. Irish Medical Times: Monthly Index of Medical Specialties. Retrieved on July 16, 2015 from

Hospital Ethics to Do or
Words: 5897 Length: 20 Pages Document Type: Term Paper Paper #: 97807504
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The clinical trial team includes doctors, nurses, social workers, data entry technicians and other health care professionals (NWHRC 2005). They review a participant's health history and current medical intakes before the trial begins. They impart adequate information and instructions about the clinical trial, monitor each participant in the conduct of the trial and may contact the participant after the conduct of the trial.

Clinical trials or researches may also be open-label, placebo-controlled, double-blinded or randomized. They consist of four phases. Phase I establishes the maximum safe dosage; Phase II, its effectiveness; Phase III, its use on a broad population; and Phase IV, post-FDA insights on the effects of its long-term use (NWHRC).

From 1999 to 2000 alone, the Food and Drug Administration approved 73 new medications (NWHRC 2005). These included drugs for HIV, cancer, heart attack and Alzheimer's disease. As of 2000, Medicare covers many of the costs involved in…


Billings, P.R. (2002). Should reproductive cloning be made available to people who want their own biologic chidren - pro and con. 2 pages. International Medical News Group: Gale Group

Deneen, S. (2001). Designer people. 9 pages. E: the Environmental Magazine: Earth Action Network, Inc.

Frankel, S., et al. (2000). The limits to demand for health care. 10 pages. British Medical Journal: British Medical Association

Hollander, D. (2005). Abortion support slipping. 2 pages. Perspectives on Sexual and Reproductive Health: the Allen Guttmacher Institute

Macpherson Thorpe and Thomas 2006 Reported an
Words: 2481 Length: 8 Pages Document Type: Article Review Paper #: 58109216
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MacPherson, Thorpe, and Thomas (2006) reported an interesting qualitative study on the use of acupuncture in the treatment of low back pain. They report the results of a qualitative study nested within a large quantitative study (there were actually tow qualitative studies performed but the current study only addresses one of them). The quantitative study design was one of a large randomized controlled trial that compared acupuncture against typical general practitioner care. The study was carried out York between the years 1999 and 2003. The acupuncture treatment for the study was founded on the principles of Traditional Chinese Medicine (TCM) using six acupuncturists who all had a minimum of three years of post-qualification clinical experience. The acupuncturists were encouraged by the researchers to provide their typical treatment so that the study would evaluate the effect of routine care for lower back pain, each acupuncturist making meticulous notes of the aspects…


Campbell, A. (2006). Point specificity of acupuncture in the light of recent myofascial pain.

Acupuncture Medicine, 24(3), 118-122.

MacPherson, H., Thorpe, L., & Thomas, K. (2006). Beyond needling therapeutic processes in acupuncture care: A qualitative study nested within a low-back pain trial. Journal of Alternative and Complementary Medicine, 12, 873-880.

Contingency Management Alcohol & Marijuana
Words: 11354 Length: 41 Pages Document Type: Term Paper Paper #: 27822679
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" (1995)

The authors state: "The amphetamines occasioned dose-related increases in d- amphetamine-appropriate responding, whereas hydromorphone did not. Amphetamines also occasioned dose-related increases in reports of the drug being most like "speed," whereas hydromorphone did not. However, both amphetamines and hydromorphone occasioned dose-related increases in reports of drug liking and in three scales of the ARCI. Thus, some self-report measures were well correlated with responding on the drug-appropriate lever and some were not. Lamb and Henningfield (1994) suggest that self-reports are complexly controlled by both the private event and the subject's history of experience with the drug. Some of the self-reports they observed (e.g., feels like speed) are probably occasioned by a relatively narrow range of stimuli because in the subject's experience with drug administration, these reports have been more selectively reinforced by the verbal community relative to other reports (e.g., drug liking). They also suggest that these results imply…


Budney, Alan J. et al. (2006) Clinical Trial of Abstinence-Based Vouchers and Cognitive-Behavioral Therapy for Cannabis Dependence. Journal of Consulting and Clinical Psychology 2006. Vol.. 74 No. 2. 2006 American Psychological Association.

McRae, a.; Budney, a.; & Brady, K. (2002) Treatment of Marijuana Dependence: A Review of the Literature. Journal of Substance Abuse Treatment 24 (2003)

Pathways of Addiction: Opportunities in Drug Abuse Research (1996) Institute of Medicine (IOM)

Kamon, J; Budney, a. & Stanger, C. (2005)a Contingency Management Intervention for Adolescent Marijuana Abuse and Conduct Problems. Journal of the American Academy of Child & Adolescent Psychiatry. 44(6):513-521, June 2005.

Warfarin vs Debagatrin
Words: 1986 Length: 4 Pages Document Type: Research Paper Paper #: 56680608
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Efficacy and Safety of Dabigatran vs. Warfarin for Stroke

After more than five decades as the preferred anticoagulant worldwide, warfarin is being challenged by a new rival that doesn't require careful dosage monitoring. Pradaxa (dabigatran) was unanimously approved by the FDA on October 19, 2010 for treating atrial fibrillation (AF) patients, who are at an increased risk for suffering stroke and systemic embolisms (.S. Food and Drug Administration). Dabigatran acts by binding directly to thrombin. Warfarin (Coumadin) is an anticoagulant that functions by inhibiting the synthesis of vitamin K-dependent clotting factors (Lemos et al., 770-771). Variations in the levels of vitamin K in the diet can influence how effective a given dose of warfarin is for a patient, so appropriate therapeutic dosages are determined on an individual basis periodically through a standardized clotting test (international normalized ratio [INR]). Even though warfarin can reduce the risk of stroke in AF patients…

U.S. Food and Drug Administration. "FDA News Release: FDA approves Pradaxa to prevent stroke in people with atrial fibrillation." U.S. Food and Drug Administration, 19 Oct. 2010. Web. 22 Jan. 2011.

Schulman, Sam, Kearon, Clive, Kakkar, Ajay K., Mismetti, Patrick, Schellong, Sebastian, Eriksson, Hentry, Baanstra, David, Schnee, Janet, and Goldhaber, Samuel Z. "Dabigatran vs. warfarin in the treatment of acute venous thromboembolism." New England Journal of Medicine 361 (2009): 2342-2352. Web.

Wallentin, Lars, Yusuf, Salim, Ezekowitz, Michael D., Alings, Marco, Flather, Marcus, Franzosi, Maria Grazia, Pais, Prem, Dans, Antonio, Eikelboom, John, Oldgren, Jonas, Pogue, Janice, Reilly, Paul A., Yang, Sean, Connolly, and Stuart J., on behalf of the RE-LY investigators. "Efficacy and safety of dabigatran compared with warfarin at different levels of international normalized ratio control for stroke prevention in atrial fibrillation: an analysis of the RE-LY trial." Lancet 376 (2010): 975-983. Web.

Testing of New Drugs
Words: 722 Length: 2 Pages Document Type: Essay Paper #: 52056173
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Flow Diagram

The author of this report has been to assess a data flow diagram that makes reference to clinical trials. For each step in the clinical trial, the author of this response will speak to what personnel would be involved with that step of the process. Indeed, the data flow diagram in question is seventeen steps long and the litany of personnel involved with each step can be moderate to extensive. While some may think that clinical trials are fairly mundane and easy to pull off, that is simply not the case and the process is indeed extensive and potentially circuitous depending on how things go (FDA, 2016).

Questions Answered

Step one of the diagram involves protocol development. The personnel involved would include medical writers, physicians, medical experts, project managers, biostatisticians and data managers. The protocols and rules of the study are important and must be defined. Step two…


FDA. (2016). Step 3: Clinical Research. Retrieved 14 January 2016, from 

NIH. (2016). Steps Involved in Clinical Research Efforts. Retrieved 14 January 2016, from

Management of Left Ventricular Heart
Words: 3436 Length: 12 Pages Document Type: Essay Paper #: 90872428
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(NHS Institute for Innovation and Improvement, 2008)

The Angiotensin-converting enzyme inhibitors are stated to be "recommended as first-line treatment in all people with left ventricular systolic dysfunction (LVSD) "with or without symptoms of heart failure." (NHS Institute for Innovation and Improvement, 2008) Additionally it is stated that strong evidence exists that ACE inhibitors "...increase life expectancy in people with LVSD and reduce the risk of hospitalization -- the effect is greatest in those with more severe LVSD or more severe symptoms, but benefit occurs for all degrees of severity." (NHS Institute for Innovation and Improvement, 2008)

Prescribed for individuals who are intolerant of ACE inhibitors due to cough are

Angiotensin-II receptor antagonists which provide an alternative to angiotensin converting enzyme (ACE) inhibitors." (NHS Institute for Innovation and Improvement, 2008) There is stated to be evidence that AIIRAs supports life expectancy improvement and symptoms for those with heart failure due to…


Clinical Practice Guideline for Heart Failure Due to Left-Ventricular Systolic Dysfunction (2000) Kaiser Diagnostic and Treatment Documents. February 2000. Online available at: http://*****/cajud/heart/leftven.html

Heart Failure: Age from 16 Years Onwards (2008) Clinical Knowledge Summaries. NHS Institute for Innovation and Improvement. Online available at:

NHS Confederation and BMA (2005) New GMS contract. Department of Health.

NICE (2002) Guidance on the use of nicotine replacement therapy (NRT) and bupropion for smoking cessation. Technology appraisal no.39. National Institute for Health and Clinical Excellence. [Accessed: 19/06/2007]. [Free Full-text]

Imagery Literature Review Guided Imagery
Words: 1189 Length: 3 Pages Document Type: Literature Review Paper #: 38369494
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Participants filled out a Short-Form McGill Questionnaire, an Arthritis Self-Efficacy Scale, and Fibromyalgia Impact Questionnaire in order to measure their levels of pain over the past few weeks. What the researchers found through statistical analysis was self-management strategies that reduced pain over time were most effective in the group that was exposed to guided imagery techniques. The level of guided imagery therapy was not itself significant, but more of the fact of whether or not it was present in the patient's therapy or not. This helps illustrate the effectiveness of guided imagery in managing long-term chronic pain when there are no fundamental cures present within traditional therapeutic practices. Pain management symptoms improved, but the symptoms overall remained. This shows that guided imagery is not a cure in and of itself, but rather an effective way to reduce and manage the pain that is present in chronic conditions like fibromyalgia.



Ferrell, Betty R., et al. "Pain management for elderly patients with cancer at home." CANCER-PHILADELPHIA- 74 (1994): 2139-2139.

Menzies, V., Taylor, a.G., & Bourguignon, C. (2006). Effects of guided imagery on outcomes of pain, functional status, and self-efficacy in persons diagnosed with fibromyalgia. Journal of Alternative & Complementary Medicine, 12(1), 23-30.

Weydert, J.A., Shapiro, D.E., Acra, S.A., Monheim, C.J., Chambers, a.S., & Ball, T.M. (2006). Evaluation of guided imagery as treatment for recurrent abdominal pain in children: a randomized controlled trial. BMC pediatrics, 6(1), 29.

Webster Et Al 2007 Is Effective Because
Words: 2606 Length: 8 Pages Document Type: Essay Paper #: 33073157
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Webster et al. 2007) is effective because it clearly identifies the purpose and nature of the study in the trial itself. The CONSOT criteria specifically state that the randomized nature of the trial must be indicated in the title, which is evident in the case of the present study. andomized trials are necessary for health care studies because they help to maintain the homogeneity of the samples (Jadad & Enkin, 2007). It also eliminates selection bias (Piantadosi, 2005). Hence, it may be said that the title is effective because it states that the study was based on a randomized trial.

It is necessary for an effective abstract to have a structured summary of the research design, methods, results, and conclusion. The abstract provides a concise, clear and well-structured summary for the reader. The information has been organized separately to facilitate comprehension. The abstract describes the background, objective, design, setting, participants,…


Jadad, A.R., & Enkin, M.W. (2008). Randomized controlled trials. (2nd ed., p. 5). Blackwell Publishing.

Kirch, W. (2008). Encyclopedia of public health. (p. 414). Springer Science.

Kumar, R. (2008). Research methodology. (p. 25). APH Publishing Corporation.

Osborn, C.E. (2006). Statistical applications for health information management. (2nd ed., p. 261). Jones & Bartlett.

Voluntary Collaborative and Active Involvement of the
Words: 2082 Length: 5 Pages Document Type: Essay Paper #: 43265959
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voluntary, collaborative and active involvement of the patient in a course of behaviour that is mutually accepted in order to gain therapeutic result (Michael, H. et al., 2009). According to this definition it can be clearly observed that the patient has a clear choice to follow the goal and that the patient and well as the providers agree to make a medical regimen and treatment goals (Delamater, 2006).

There are two basic factors involved in the medical adherence, these are:

Whether the patients takes the medicine that has been prescribed to him/her.

Whether the patient keeps on taking the prescribed medicine or not.

Therefore, the adherence behaviour is divided into 2 main concepts which are: adherence and persistence. Although the concept of adherence and persistence is similar however, adherence means the intensity with which the drug was taken during the duration of the therapy while, persistence means the overall duration…

Urquhart J. The electronic medication event monitor: lessons for pharmacotherapy. Clin Pharmacokinet. 1997; 32: 345 -- 356.

Vrijens B, Vincze G, Kristanto P, Urquhart J, Burnier M. Adherence to prescribed antihypertensive drug treatments: longitudinal study of electronically compiled dosing histories. BMJ. 2008; 336: 1114 -- 1117.

World Health Organization. 2003. Adherence to Long-Term Therapy: Evidence for Action. Available at: .