Sign Up Now
Get instant access to over 1 million+ study documents
OR
Already registered? click here to login
By creating your account, you agree to our terms of service, privacy policy and student honor code.
There are two tumors that are often mistaken for GISTs and specifically those known as: (1) Fibromatosis; and (2) leomysarcoma. (Rubic, Heinrich, and Corless, 2007)
Findings in this study include that there apparently are genetic bases for development of gastrointestinal stromal tumor and that in the Chinese population that when comparing the U.S. And Hong Kong demonstrates that Hong Kong is comparable to the U.S. And lower than Finland. This is likely to be true for the entire Chinese population although this fact could not be confirmed in the present study. Findings in this study additional include the findings that the previous optimal treatment for GISTs is likely not to be the best method of treating this condition and indicating that further and additional research is required toward the necessity and needs of different treatment options that are evidence-based and found to be more effective in treating this condition.
Bibliography
Azhar, a.H.S., et al. (2009) a Retrospective Cohort Study of Gastrointestinal Stromal Tumours (Gist) in Husm for the Last 12 Years (1997 -- 2008) Department of Surgery, School of Medical Sciences, University Sains Malaysia, Kubang Kerian, Kelantan, Malaysia. Online available at: http://www.colorectalmy.org/events/coloproctology_2009.pdf
Chan K, Chan C, Chow W, Kwan W, Kong C, Mak K, Leung M, Lau L.Gastrointestinal stromal tumors in a cohort of Chinese patients in Hong Kong.World J. Kastroenterol 2006 April;12(14):2223-2228
Corless, CL; Fletcher, JA, and Heinrich, MC (2004) Biology of gastrointestinal stromal tumors. Clin Oncol. 2004 Sep 15;22(18):3813-25.
Demetri GD, von Mehren M, Blanke CD, et al.: Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J. Med 347:472-480, 2002.
Heinrich MC, Corless CL, Duensing a, et al.: PDGFRA activating mutations in...
Science 299:708-710, 2003.
Mazur MT, Clark HB: Gastric stromal tumors. Reappraisal of histogenesis. Am J. Surg Pathol 7:507-519, 1983.
Medeiros F, Corless CL, Duensing a, et al.: Kit-negative gastrointestinal stromal tumors: Proof of concept and therapeutic implications. Am J. Surg Pathol 28:889-894, 2004.
Miettinen M, Furlong M, Sarlomo-Rikala M, et al.: Gastrointestinal stromal tumors, intramural leiomyomas, and leiomyosarcomas in the rectum and anus: A clinicopathologic, immunohistochemical, and molecular genetic study of 144 cases. Am J. Surg Pathol 25:1121-1133, 2001.
Miettinen M, Lasota J: Gastrointestinal stromal tumors: Pathology and prognosis at different sites. Semin Diagn Pathol 23:70-83, 2006.
Miettinen M, Sobin LH, Lasota J: Gastrointestinal stromal tumors of the stomach: A clinicopathologic, immunohistochemical, and molecular genetic study of 1765 cases with long-term follow-up. Am J. Surg Pathol 29:52-68, 2005.
Miettinen M, Virolainen M, Maarit SR: Gastrointestinal stromal tumors -- Value of CD34 antigen in their identification and separation from true leiomyomas and schwannomas. Am J. Surg Pathol 19:207-216, 1995[Medline]
Mikhael AI, Bacchi CE, Zarbo RJ, et al.: CD34 expression in stromal tumors of the gastrointestinal tract. Appl Immunohistochem 2:89-93, 1994
Rubin BP, Heinrich MC, Corless CL: Gastrointestinal stromal tumour. Lancet 369:1731-1741, 2007.
Tzen, Chi-Yuan (2007) Incidence of Gastrointestinal Stromal Tumor: A Retrospective Study Based on Immunohistochemical and Mutational Analyses. Digestive Diseases and Sciences. 26 Jan 2007. vol. 52, No. 3.
Zhou, Weixun; Zeng, xuan; and Liu, Tonghua (2009) Aberrations of Chromosome 13q in Gastrointestinal Stromal Tumors: Analysis of 91 Cases by Fluorescence in Situ Hybridization…
Bibliography
Azhar, a.H.S., et al. (2009) a Retrospective Cohort Study of Gastrointestinal Stromal Tumours (Gist) in Husm for the Last 12 Years (1997 -- 2008) Department of Surgery, School of Medical Sciences, University Sains Malaysia, Kubang Kerian, Kelantan, Malaysia. Online available at: http://www.colorectalmy.org/events/coloproctology_2009.pdf
Chan K, Chan C, Chow W, Kwan W, Kong C, Mak K, Leung M, Lau L.Gastrointestinal stromal tumors in a cohort of Chinese patients in Hong Kong.World J. Kastroenterol 2006 April;12(14):2223-2228
Corless, CL; Fletcher, JA, and Heinrich, MC (2004) Biology of gastrointestinal stromal tumors. Clin Oncol. 2004 Sep 15;22(18):3813-25.
Demetri GD, von Mehren M, Blanke CD, et al.: Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J. Med 347:472-480, 2002.
Zhou, Weixun; Zeng, xuan; and Liu, Tonghua (2009) Aberrations of Chromosome 13q in Gastrointestinal Stromal Tumors: Analysis of 91 Cases by Fluorescence in Situ Hybridization (FISH)Diagnostic Molecular Pathology: June 2009 - Volume 18 - Issue 2 - pp 72-80. Online available at: http://journals.lww.com/molecularpathology/Abstract/2009/06000/Aberrations_of_Chromosome_13q_in_Gastrointestinal.3.aspx
Schizophrenia on the Mind and Body An Analysis of the Etiology of Schizophrenia and Its Impact on the Mind and Body Perhaps no other human condition has received so much publicity, but remains so misunderstood by the general public as schizophrenia. Schizophrenia is widely believed to be associated with multiple personalities and other acute symptoms that would make sufferers readily apparent; however, the reality of the condition is that people can
Neuropsychological and Genetic Factors Surrounding Alzheimer's Disease Alzheimer's disease is a debilitating illness that interferes with an individual's ability to recall short-term and long-term memory. People diagnosed with the disease can initially recall recent activities though they have difficulties with long-term memory. However, these patients have difficulties with short- and long-term memory over time as the disease develops. Given the increase in the number of people diagnosed with this condition, Alzheimer's
One important aspect was that research findings suggested that PTSD was more common than was thought to be the case when the DSM-III diagnostic criteria were formulated. (Friedman, 2007, para.3) the DSM-IV diagnosis of PTSD further extends the formalization of criteria as well as the methodological consistency for PTSD and now includes six main criteria. The first of these criteria qualifies the meaning of trauma. A traumatic event is
' If a person does not disclose their drinking behavior if they seek outside help, they may be misdiagnosed as having an anxiety disorder. Mixing alcohol and medications for anxiety disorders can have lethal consequences, as well as prolonging a process of addiction." (Losinno, p. 1) This denotes that especially in the face of trauma, those who are predisposed to dissonant responses and unhealthy coping mechanisms will struggle at a higher
A while in the past half century the United States has made significant overall progress toward the objective of ensuring equal treatment under the law for all citizens, in the critical area of criminal justice, racial inequality appears to be growing, not receding, and our criminal laws, while facially neutral, are enforced in a manner that is massively and pervasively biased. Dunnaville) The above report and others also states that there were,"...serious
Studies indicate that "... A higher than average incidence of delinquency occurs among youngsters of the poorest social standing and with the lowest performance at school..." (Jarvelin et al., 1994, p. 230) Similarly, studies also note that neighborhood influences on development was determinant on factors such as "...collective socialization, peer-group influence, and institutional capacity." (Sampson, Morenoff & Gannon-Rowley, 2002. p 443) Generally studies like the above present a negative picture of