Atherosclerosis

Atherosclerosis is one of the major causes of premature disability and death in developed nations. It is estimated that this condition will become the leading cause of total disease burden in the near future because its development is fueled by multiple generalized or systemic risk factors. Rao & Kiranmayi1 note that the condition is a dynamic and progressive disease that is brought about by an injury to endothelium and its associated inflammatory response. Since atherosclerosis is likely to become the leading cause of disease burden in developed countries, an understanding of the condition is essential to enhance prevention. Insights into the biochemical basis and clinical implications of atherosclerosis are essential to promote a better understanding and management of the condition.

Biochemical Basis and Clinical Implications of Atherosclerosis

Atherosclerosis is a disease brought by various causes and is regarded as the primary underlying cause of cardiovascular diseases and cerebrovascular accidents. The biochemical mechanisms underlying this condition involve lipid accumulation and immune activation that take place in the vascular wall. Alfarisi, Mohamed & Ibrahim2 state that inflammation,...

Immune activation and lipid accumulation are processes that are highly regulated by several specialized lipid and protein mediators. These mediators either promote the development of atherosclerosis by stimulating inflammation or inducing resolution of inflammation, which makes them anti-atherosclerosis. Blood vessels play an important role in the development of atherosclerosis as they are generally exposed to several...…atherosclerosis is a progressive condition brought about by an injury to the endothelium and its associated inflammatory response. As evident in this discussion, the injury to endothelium is in turn influenced by underlying biochemical processes relating to inflammation and oxidation. The complex interactions between biological and mechanical factors influence the development of the condition by affecting lesion development and plaque stabilization. Therefore, new therapeutic strategies for atherosclerosis should be centered on enhancing plaque stabilization and lesion development. Such strategies should be supported by appropriate health behaviors as emphasized in the bible. Biblical teachings in 3 John 1:2 and 1 Corinthians 10:31 emphasize enjoying good health and making suitable health choices. These teachings are important in the prevention of this condition and enhancing the effectiveness…