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Vaccine Supply Chain
Critical challenges of the vaccine supply chain due to the COVID-19 pandemic had to do with cold storage, transportation, global distribution, and regulatory hurdles (Crommelin et al., 2021). Moderna and Pfizer both faced these challenges in scaling up and distributing their vaccines. This paper describes and discusses a few of them.
First, the Pfizer and Moderna vaccines required ultra-cold storage. Pfizer vaccine needed to be stored at about -70C (-94F), while Moderna's required -20C (-4F). These temperature conditions necessitated the use of specialized freezers and storage solutions. Since such infrastructure was not widely available, particularly in low-resource settings, it made distribution in some parts of the world very difficult (Crommelin et al., 2021).
This cold chain, however, had to be maintained throughout transportation. This meant using specialized containers filled with dry ice and equipped with real-time temperature monitoring. The transportation process had to be resilient enough to account for potential disruptions, too (Olutuase et al., 2022).
The global demand for COVID-19 vaccines was also immense, and this meant that both companies had to scale up production rapidly. There was thus an overwhelming demand for specific raw materials, such as the lipids used in the mRNA vaccine formulation, which actually faced potential shortages,...…only a handful of suppliers existed globally. This limited supplier base posed a risk: any disruption or setback with even one supplier could have cascading effects on the entire production process.
Thus, addressing the many different challenges was not easy. Pfizer and Moderna had to work closely with governments to manage it all and ensure global coordination at a truly international level. Governments, international organizations, the private sector, and civil society all acted as stakeholders, coming together to support the production and distribution of vaccines. This overall collective experience represented the critical support that both Pfizer and Moderna received and without which neither…
References
Crommelin, D. J., Anchordoquy, T. J., Volkin, D. B., Jiskoot, W., & Mastrobattista, E. (2021).
Addressing the cold reality of mRNA vaccine stability. Journal of pharmaceutical sciences, 110(3), 997-1001.
Olutuase, V. O., Iwu-Jaja, C. J., Akuoko, C. P., Adewuyi, E. O., & Khanal, V. (2022). Medicinesand vaccines supply chains challenges in Nigeria: a scoping review. BMC Public Health, 22, 1-15.
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