Ways to Prevent and Treat Kidney Disease

Polycystic Kidney Disease

Introduction

Polycystic Kidney Disease (PKD) is a genetic disorder characterized by the growth of numerous cysts in the kidneys. These cysts are filled with fluid and can cause the kidneys to become enlarged and dysfunctional. PKD can cause a wide range of symptoms, including pain, hypertension, kidney failure, and an increased risk of urinary tract infections. PKD is not a disease that can be readily cured, but there are available treatments that can help to control the symptoms and slow the progression of the disease. Early diagnosis and treatment are essential for maximizing the chances of a good outcome.

Criteria

PKD is diagnosed using a combination of clinical criteria and imaging tests. The clinical criteria for diagnosing PKD include the presence of two or more cysts in each kidney, renal cysts in a first-degree relative, and/or renal impairment due to PKD. Imaging tests such as ultrasounds, CT scans, and MRI scans can be used to confirm the presence of kidney cysts. In some cases, genetic testing may also be performed to confirm a diagnosis of PKD.

There is no cure for PKD, but there are treatments that can help to control the symptoms and slow the progression of the disease (Patel et al., 2009). Treatments for PKD include ACE inhibitors (to control blood pressure), diuretics (to reduce fluid retention), pain relievers, and antibiotics (to treat urinary tract infections). In some cases, surgery may also be necessary to drain cysts or remove diseased kidneys. kidney transplants may also be an option for patients with end-stage renal failure.

PKD is a serious condition that can lead to significant morbidity and mortality if left untreated. However, with early diagnosis and treatment, many patients with PKD are able to live long and healthy lives.

Description of the pathology

Due to cysts that are filled with fluid and can range in size from a few millimeters to several centimeters, PKD can cause the kidneys to become enlarged and can lead to kidney failure. The exact cause of PKD is unknown, but it is believed to be associated with a mutation in a gene that regulates cell division. Some researchers have indicated that pathology may be due to defects in cilia-mediated signaling activity (Patel et al., 2009). Halvorson et al. (2010) have stated that “PKD is thought to result from defects in the primary cilium, an immotile, hair-like cellular organelle present on the surface of most cells in the body, anchored in the cell body by the basal body” (p. 70). The research on pathology continues still, however.

Normal anatomy of major body system affected

The kidneys are a pair of organs located in the back of the abdomen, just below the ribs. Each kidney is about the size of a fist and weighs approximately 150 grams. The kidneys filter blood and remove wastes from the body in the form of urine. They also help to regulate fluid levels, blood pressure, and red blood cell production. The kidneys are connected to the urinary tract, which carries urine from the kidneys to the bladder. The bladder stores urine until it is ready to be expelled from the body through the urethra.

The anatomy of the kidney is fairly complex. The kidney consists of two main parts: the renal cortex and the renal medulla (Wallace, 1998). The renal cortex is the outer region of the kidney, and it contains the bulk of the renal tissue. The renal medulla is the inner region of the kidney, and it contains the renal pelvis, which collects urine from the kidney calyces before it enters the ureter. The kidney also has a number of other important structures, including the glomeruli, which filter blood; the renal tubules, which reabsorbs nutrients and water; and the juxtaglomerular apparatus, which regulates blood pressure.

Mechanism of pathophysiology

There are two types of PKD: autosomal dominant PKD and autosomal recessive PKD. Autosomal dominant PKD is the more common type and occurs when a person inherits a mutated gene from one parent. Autosomal recessive PKD is less common and occurs when a person inherits mutated genes from both parents. People with autosomal recessive PKD generally have a more severe form of the disease. There is no cure for PKD, but there are treatments that can help to slow its progression and relieve its symptoms. However, as Halvorson et al. (2010) point out, “vascular manifestations of ADPKD are thought to also be related to abnormal functioning of polycystin-1 and polycystin-2, which additionally have been found to be expressed in vascular smooth muscle and endothelium” (p. 72). This is thought to result from intercellular changes in homeostasis.

Prevention

Because it is unclear what actually causes PKD, prevention is also uncertain. However, avoiding risk factors, such as poor diet, stress, and anything that can damage the body (drugs or alcohol) is generally viewed as preventive. If one is already leading a lifestyle that is risky for this type of disease, lifestyle changes, such as following a low-sodium diet and maintaining a healthy weight, are usually recommended so as not to contribute to risk.

Treatment